Catalog No.
FMG01810
Species reactivity
Human, Mouse
Host species
Rat
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O35516, Q61982
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
59R1
Treatment outcomes of BTK inhibitors and venetoclax with or without anti-CD20 monoclonal antibody in relapsed or refractory mantle cell lymphoma., PMID:40278919
Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan., PMID:39931207
Combined Molecular Subclass and Immune Phenotype Correlate to Atezolizumab Plus Radiation Therapy Response in Invasive Bladder Cancer: BPT-ART Phase 2 Study., PMID:39755215
TP53 Mutation Is the Only Robust Mutational Biomarker for Outcome Found in a Consecutive Clinical Cohort of Real-Word Patients With Primary Large B-Cell Lymphoma., PMID:39691999
Truncated recombinant Jagged1 fused with human IgG1 Fc activates Notch target genes in human periodontal ligament cells., PMID:39643955
Modulation of Notch signaling pathway in activated hepatic stellate cells does not ameliorate the outcome of liver fibrosis in carbon tetrachloride and DDC-feeding models., PMID:39529885
Familial adult-onset neuronal intranuclear inclusion disease: A case report and literature review., PMID:39496005
Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME., PMID:39491031
The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1., PMID:39451043
Application of Monoclonal Antibodies against Naturally Occurring Bioactive Ingredients., PMID:39189231
Notch2 signaling governs activated B cells to form memory B cells., PMID:38990721
Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform., PMID:38547109
Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization., PMID:38438375
Notch-1/2 receptors and Jagged-1 ligand, but not HERP-1 transcription factor, are immunohistochemically expressed in the epithelial lining of periapical cysts., PMID:38314334
Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing., PMID:38175592
NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α., PMID:37865314
Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome., PMID:37587118
Trastuzumab-induced human cardiomyocyte damage through the Notch2/JAK2/STAT3 pathway., PMID:37567042
Genomics of ERBB2-Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab., PMID:37364233
DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance., PMID:37235754
Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis., PMID:37218430
Clinical, radiological, and molecular analyses of neuronal intranuclear inclusion disease with polyglycine inclusions., PMID:37001413
Waldenström Macroglobulinemia and Non-IgM-Type Lymphoplasmacytic Lymphoma Are Genetically Similar., PMID:36917966
CK2β-regulated signaling controls B cell differentiation and function., PMID:36713383
Role of Notch2 pathway in mature B cell malignancies., PMID:36686759
Exploratory use of romosozumab for osteoporosis in a patient with Hajdu-Cheney syndrome: a case report., PMID:36622389
Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response., PMID:36155282
Notch Signaling Promotes Mature T-Cell Lymphomagenesis., PMID:36006995
Therapeutic Targeting Notch2 Protects Bone Micro-Vasculatures from Methotrexate Chemotherapy-Induced Adverse Effects in Rats., PMID:35954226
Extra arginine supplementation during the suckling period alleviates weaning stress through the regulation of dendritic cells and Notch2 signaling in piglets., PMID:35899814
FcγRIIB regulates autoantibody responses by limiting marginal zone B cell activation., PMID:35819855
Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype., PMID:35752075
Pancreatic-Like Cells Derived From Mouse Embryonic Stem Cells Are Regulated by Pdx1 Involving the Notch Pathway., PMID:35695761
Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells., PMID:35579963
Notch2 Blockade Mitigates Methotrexate Chemotherapy-Induced Bone Loss and Marrow Adiposity., PMID:35563828
Methotrexate treatment suppresses osteoblastic differentiation by inducing Notch2 signaling and blockade of Notch2 rescues osteogenesis by preserving Wnt/β-catenin signaling., PMID:34935186
Revised International Prognostic Index and genetic alterations are associated with early failure to R-CHOP in patients with diffuse large B-cell lymphoma., PMID:34632572
Oral Surgery Procedures in a Patient with Hajdu-Cheney Syndrome Treated with Denosumab-A Rare Case Report., PMID:34501688
Cooperation Between Cancer and Fibroblasts in Vascular Mimicry and N2-Type Neutrophil Recruitment via Notch2-Jagged1 Interaction in Lung Cancer., PMID:34485133
Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation., PMID:34473651
Delta-like 1-Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse., PMID:34438113
Risk-tailored treatment of splenic marginal zone lymphoma., PMID:34407041
Protein Kinase CK2 Regulates B Cell Development and Differentiation., PMID:34301844
Profiling of 520 Candidate Genes in 50 Surgically Treated Chinese Small Cell Lung Cancer Patients., PMID:34168983
A Homozygous Dab1-/- Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract., PMID:33924028
Adult-onset neuronal intranuclear inclusion disease, with both stroke-like onset and encephalitic attacks: a case report., PMID:33789591
Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren's Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease., PMID:33671965
BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation., PMID:33534893
High expression of Notch2 drives tongue squamous cell carcinoma carcinogenesis., PMID:33382997
O-Fucose and Fringe-modified NOTCH1 extracellular domain fragments as decoys to release niche-lodged hematopoietic progenitor cells., PMID:33351914
For research use only. Not for human or drug use.
