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Anti-Mouse CD134/TNFRSF4/OX40 Antibody (OX-86)

Catalog #:   FME43210 Specific References (50) DATASHEET
Host species: Rat
Isotype: IgG1, kappa
Applications: FCM
Accession: P47741
Overview

Catalog No.

FME43210

Species reactivity

Mouse

Host species

Rat

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

ACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P47741

Applications

FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

OX-86

Data Image
References

Recognition of different subsets of alloreactive T cells by activation-induced markers., PMID:40204006

Activation of immune checkpoint OX40 inhibits HBV replication in a mouse model., PMID:39923582

Tumor-Infiltrating Immune Cells and HLA Expression as Potential Biomarkers Predicting Response to PD-1 Inhibitor Therapy in Stage IV Melanoma Patients., PMID:39766316

A Phase I Clinical Trial Adding OX40 Agonism to In Situ Therapeutic Cancer Vaccination in Patients with Low-Grade B-cell Lymphoma Highlights Challenges in Translation from Mouse to Human Studies., PMID:39745391

SHR-1806, a robust OX40 agonist to promote T cell-mediated antitumor immunity., PMID:39543823

Making the effect visible - OX40 targeting nanobodies for in vivo imaging of activated T cells., PMID:39474429

From structural design to delivery: mRNA therapeutics for cancer immunotherapy., PMID:38855617

The Role of OX40-OX40L Axis in the Pathogenesis of Atopic Dermatitis., PMID:38700255

Regulation of the Function of T Follicular Helper Cells and B Cells in Type 1 Diabetes Mellitus by the OX40/OX40L Axis., PMID:38625053

An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026

OX40/OX40 ligand and its role in precision immune oncology., PMID:38526805

OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520

Agonistic Bivalent Human scFvs-Fcγ Fusion Antibodies to OX40 Ectodomain Enhance T Cell Activities against Cancer., PMID:38140230

SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain., PMID:38012843

BAT6026, a novel anti-OX40 antibody with enhanced antibody dependent cellular cytotoxicity effect for cancer immunotherapy., PMID:37576888

Assessing SARS-CoV-2-specific T-cell reactivity in late convalescents and vaccinees: Comparison and combination of QuantiFERON and activation-induced marker assays, and relation with antibody status., PMID:37220145

Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome., PMID:37051254

The combination of oxaliplatin and anti-PD-1 inhibitor promotes immune cells infiltration and enhances anti-tumor effect of PD-1 blockade in bladder cancer., PMID:36960067

First-in-human phase I study of the OX40 agonist GSK3174998 with or without pembrolizumab in patients with selected advanced solid tumors (ENGAGE-1)., PMID:36927527

Multicentric IL-5-positive Castleman Disease With Nephrotic Syndrome Relapsed After Rituximab Treatment., PMID:36593046

In Situ Reprogramming of Tumors for Activating the OX40/OX40 Ligand Checkpoint Pathway and Boosting Antitumor Immunity., PMID:35653749

Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti-spike neutralizing IgG to SARS-CoV-2 variants, but preserved antigen-specific T cell responses., PMID:35607995

Antigen-Specific CD4+ T-Cell Activation in Primary Antibody Deficiency After BNT162b2 mRNA COVID-19 Vaccination., PMID:35237272

Approaches of the Innate Immune System to Ameliorate Adaptive Immunotherapy for B-Cell Non-Hodgkin Lymphoma in Their Microenvironment., PMID:35008305

Anti-tumour effect of in situ vaccines combined with VEGFR inhibitors in the treatment of metastatic cervical cancer., PMID:34717193

A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients with Locally Advanced or Metastatic Cancers., PMID:34615725

Immune Assessment of BNT162b2 m-RNA-Spike Based Vaccine Response in Adults., PMID:34440072

New Biologics for the Treatment of Atopic Dermatitis: Analysis of Efficacy, Safety, and Paradoxical Atopic Dermatitis Acceleration., PMID:34195265

Generation and characterization of a high-affinity chimeric anti-OX40 antibody with potent antitumor activity., PMID:33792041

Prolactin Increases the Frequency of Follicular T Helper Cells with Enhanced IL21 Secretion and OX40 Expression in Lupus-Prone MRL/lpr Mice., PMID:33763492

Immunogenicity risk assessment for biotherapeutics through in vitro detection of CD134 and CD137 on T helper cells., PMID:33729092

Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma: DREAMM-5 study design., PMID:33682447

Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist., PMID:33500260

Pro-inflammatory dopamine-2 receptor-specific T cells in paediatric movement and psychiatric disorders., PMID:33425355

Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells., PMID:33293281

OX40 Agonist BMS-986178 Alone or in Combination With Nivolumab and/or Ipilimumab in Patients With Advanced Solid Tumors., PMID:33148673

Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077

FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells., PMID:32900860

Visualization of Activated T Cells by OX40-ImmunoPET as a Strategy for Diagnosis of Acute Graft-versus-Host Disease., PMID:32900772

Structural basis for the interaction of human herpesvirus 6B tetrameric glycoprotein complex with the cellular receptor, human CD134., PMID:32678833

New and Emerging Systemic Treatments for Atopic Dermatitis., PMID:32519223

Randomized, Ascending Dose, Phase 2 Study of KHK4083, an Anti-OX40 Monoclonal Antibody, in Moderately Active Ulcerative Colitis., PMID:36776497

New pathways in immune stimulation: targeting OX40., PMID:32392177

A Combination of Radiotherapy, Hyperthermia, and Immunotherapy Inhibits Pancreatic Tumor Growth and Prolongs the Survival of Mice., PMID:32326142

gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections., PMID:32295911

The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis., PMID:32176307

Development and characterization of a novel anti-OX40 antibody for potent immune activation., PMID:32078015

No Evidence for Circulating Retina Specific Autoreactive T-cells in Latent Tuberculosis-associated Uveitis and Sarcoid Uveitis., PMID:31913737

CD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo., PMID:31807014

Cancer combinatorial immunotherapy using anti-OX40 agonist and anti-PD-L1 antagonist: a patent evaluation of US2018256711A1., PMID:31216214

Datasheet
$ 165
Product specifications
50 μg 165 100 μg 272

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Anti-Mouse CD134/TNFRSF4/OX40 Antibody (OX-86) [FME43210]
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