Catalog No.
RGK24302
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
DNA, Z-DNA
Specificity
Z22 binds both Z-DNA, but not B-DNA or ssDNA (single-stranded DNA).
Concentration
1.8 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
DB, ELISA, IF
Form
Liquid
Storage buffer
100 mM Pro-Ac, 20 mM Arg, pH 5.0
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Z22
Global identification and functional characterization of Z-DNA in rice., PMID:39968963
The role of DNA in the pathogenesis of SLE: DNA as a molecular chameleon., PMID:38749573
The Binding Properties of Antibodies to Z-DNA in the Sera of Normal Healthy Subjects., PMID:38473808
The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells., PMID:37995810
Spatiotemporal expression patterns of ZBP1 in the brain of mouse experimental stroke model., PMID:37952561
The vaccinia virus E3L dsRNA binding protein detects distinct production patterns of exogenous and endogenous dsRNA., PMID:37790463
The expression of antibodies to Z-DNA in the blood of patients with systemic lupus erythematosus: Relationship to autoantibodies to B-DNA., PMID:37673226
Non-B-form DNA tends to form in centromeric regions and has undergone changes in polyploid oat subgenomes., PMID:36574697
Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells., PMID:36342164
Construction of ssDNA-Attached LR-Chimera Involving Z-DNA for ZBP1 Binding Analysis., PMID:35744832
Bacterial Biofilms Utilize an Underlying Extracellular DNA Matrix Structure That Can Be Targeted for Biofilm Resolution., PMID:35208922
The Anti-DNA Antibodies: Their Specificities for Unique DNA Structures and Their Unresolved Clinical Impact-A System Criticism and a Hypothesis., PMID:35087528
Z-DNA as a Tool for Nuclease-Free DNA Methyltransferase Assay., PMID:34769422
Z-form extracellular DNA is a structural component of the bacterial biofilm matrix., PMID:34735796
Removal of eDNA from fabrics using a novel laundry DNase revealed using high-resolution imaging., PMID:34728780
Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia., PMID:34593618
The Binding of Monoclonal and Polyclonal Anti-Z-DNA Antibodies to DNA of Various Species Origin., PMID:34445637
Topologically Constrained Formation of Stable Z-DNA from Normal Sequence under Physiological Conditions., PMID:30844265
Selection of Antibody Fragments Against Structured DNA by Phage Display., PMID:30196499
Hexon and fiber gene changes in an attenuated fowl adenovirus isolate from Malaysia in embryonated chicken eggs and its infectivity in chickens., PMID:30173491
Arterial immune protein expression demonstrates the complexity of immune responses in Kawasaki disease arteritis., PMID:28707750
Characterization of an In Vivo Z-DNA Detection Probe Based on a Cell Nucleus Accumulating Intrabody., PMID:27351554
Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells., PMID:26263206
Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells., PMID:24335288
Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter., PMID:23571756
Novel multiplexed HIV/simian immunodeficiency virus antibody detection assay., PMID:22172157
The Zalpha domain of PKZ from Carassius auratus can bind to d(GC)(n) in negative supercoils., PMID:20139004
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite., PMID:17606764
Thermodynamic basis for antibody binding to Z-DNA: comparison of a monoclonal antibody and its recombinant derivatives., PMID:16214293
Repertoire diversification in mice with an IgH-locus-targeted transgene for the rearranged VH domain of a physiologically selected anti-ssDNA antibody., PMID:15950740
Z-DNA, a new in situ marker for transcription., PMID:15145775
Calculating the etiology of systemic lupus erythematosus., PMID:14962634
Slipped (CTG).(CAG) repeats of the myotonic dystrophy locus: surface probing with anti-DNA antibodies., PMID:12963369
[Z-form of intraphage DNA]., PMID:12534267
Molecular understanding of aluminum-induced topological changes in (CCG)12 triplet repeats: relevance to neurological disorders., PMID:12379314
Novel use of bovine zeta-crystallin as a conformational DNA probe to characterize a phase transition zone and terminally differentiating fiber cells in the adult canine ocular lens., PMID:11757907
Single-chain Fv with Fc fragment of the human IgG1 tag: construction, Pichia pastoris expression and antigen binding characterization., PMID:11098129
Expression of anti-Z-DNA single chain antibody variable fragment on the filamentous phage surface., PMID:10775889
Suppression of Epstein-Barr virus reactivation in lymphoblastoid cells cultured in simulated microgravity., PMID:10475255
DNA binding by the VH domain of anti-Z-DNA antibody and its modulation by association of the VL domain., PMID:10202006
The RNA-editing enzyme ADAR1 is localized to the nascent ribonucleoprotein matrix on Xenopus lampbrush chromosomes but specifically associates with an atypical loop., PMID:10037784
Binding properties of bovine ocular lens zeta-crystallin to right-handed B-DNA, left-handed Z-DNA, and single-stranded DNA., PMID:9974216
The (gt)n(ga)m containing intron 2 of HLA-DRB alleles binds a zinc-dependent protein and forms non B-DNA structures., PMID:9889299
SLE autoantibodies binding to native calf thymus DNA brominated in high salt., PMID:9863893
Localization of B-DNA and Z-DNA in terminally differentiating fiber cells in the adult lens., PMID:9358853
The effect of antitumor trans-[PtCl2(E-iminoether)2] on B-->Z transition in DNA., PMID:9199661
Identification of processes that influence negative supercoiling in the human c-myc gene., PMID:9199252
Why the difference between B-DNA and Z-DNA?, PMID:9296781
Bacterial expression of anti-DNA antibody domains., PMID:8990084
Nucleic acid-8-methoxypsoralen crosslinks bind monoclonal anti-Z-DNA antibody., PMID:8955875
For research use only. Not for human or drug use.
