Catalog No.
RGK60301
Description
Anti-DNA G-quadruplex structures, clone BG4 Antibody, is a highly specific single-chain antibody that targets DNA G-quadruplex structures and has been tested in and ELISA, ChIP-seq
Expression system
Mammalian Cells
Species reactivity
General
Isotype
ScFv-FLAG-His
Clonality
Monoclonal
Target
DNARNA G-quadruplex, DNA G-quadruplex structures,DNA G4,DNA G-quadruplex structures,DNA G-quadruplex
Concentration
1.25 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Immobilized Metal Affinity Chromatography.
Applications
ELISA, EMSA, IF, ChIP-seq, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
BG4
Characterization of G-quadruplex antibody reveals differential specificity for G4 DNA forms. PMID: 33084858
Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes. PMID: 32216326
[Preparation and identification of DNA G-quadruplex antibody]. PMID: 26146071
BG-flow, a new flow cytometry tool for G-quadruplex quantification in fixed cells. PMID: 33706790
Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures. PMID: 34855372
G4 Sensing Pyridyl-Thiazole Polyamide Represses c-KIT Expression in Leukemia Cells. PMID: 33851760
Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle. PMID: 31002438
Light-induced in situ chemical activation of a fluorescent probe for monitoring intracellular G-quadruplex structures. PMID: 34477654
Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma. PMID: 33094287
Telomere and G-Quadruplex Colocalization Analysis by Immunofluorescence Fluorescence In Situ Hybridization (IF-FISH). PMID: 31127589
Small Molecule Driven Stabilization of Promoter G-Quadruplexes and Transcriptional Regulation of c-MYC. PMID: 29956928
An organic molecular compound for in situ identification of mitochondrial G-quadruplexes in live cells. PMID: 34940779
Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues. PMID: 25033211
GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner. PMID: 27414642
Chen, J., Duan, Y., Yang, K., Wang, J., Yan, J., Gu, C., Wang, S., Zhu, Z., Liu, E.H., and Xu, J. (2023). Design, synthesis and biological evaluation of novel 9-N-substituted-13-alkylberberine derivatives from Chinese medicine as anti-hepatocellular carcinoma agents. Bioorg Med Chem 79, 117156. PMID: 36640595
For research use only. Not for human or drug use.
