Catalog No.
FHD02510
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
MSK21, MAC-inhibitory protein, MEM43 antigen, MAC-IP, MIN2, MIRL, HRF20, Protectin, 1F5 antigen, MIC11, MIN3, Membrane inhibitor of reactive lysis, MACIF, 20 kDa homologous restriction factor, CD59, MIN1, CD59 glycoprotein, HRF-20, Membrane attack complex inhibition factor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P13987
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
TS59
Evidence for Complement Activation in Preeclampsia Placenta and Its Presence in Circulation., PMID:40388260
Comparison of monoclonal antibody to CD59 for the diagnosis of paroxysmal nocturnal hemoglobinuria by flow cytometry., PMID:40322995
Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody-Dependent Cytotoxicity., PMID:40272315
Mechanism and regulation of the complement activity in kidney xenotransplantation., PMID:40233672
Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation., PMID:40040710
Complement regulators as novel targets for anti-cancer therapy: A comprehensive review., PMID:39826189
Rituximab-IgG2 is a phagocytic enhancer in antibody-based immunotherapy of B-cell lymphoma by altering CD47 expression., PMID:39712032
Comparing methods to detect cellular proteins on the surface of HIV-1 virions., PMID:39647666
SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis., PMID:39435487
Super-resolution microscopy unveils the nanoscale organization and self-limiting clustering of CD47 in human erythrocytes., PMID:39367479
Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy., PMID:39357054
Enhanced complement activation and MAC formation accelerates severe COVID-19., PMID:39284944
Navigating the Complement Pathway to Optimize PNH Treatment with Pegcetacoplan and Other Currently Approved Complement Inhibitors., PMID:39273426
Downregulation of miRNA-26a by HIV-1 Enhances CD59 Expression and Packaging, Impacting Virus Susceptibility to Antibody-Dependent Complement-Mediated Lysis., PMID:39066239
CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex., PMID:38928601
Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome., PMID:38854038
Anti-pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation., PMID:38853364
CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex., PMID:38645247
A 21-bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course., PMID:38528725
Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study., PMID:38438427
CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells., PMID:38361357
The complement cascade in lung injury and disease., PMID:38178176
FLAER as a standalone reagent for paroxysmal nocturnal hemoglobinuria: Do we need to reconsider the guidelines for testing?, PMID:38069562
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides., PMID:38053024
Functionalized Graphene Quantum Dots (GQDs) based Label-Free Optical Fluorescence Sensor for CD59 Antigen Detection and Cellular Bioimaging., PMID:37976023
Complement-membrane regulatory proteins are absent from the nodes of Ranvier in the peripheral nervous system., PMID:37875972
Metalloporphyrins Reduce Proteinuria in Podocyte Immune Injury: The Role of Metal and Porphyrin Moieties., PMID:37628958
Comprehensive cell surface protein profiling of human mesenchymal stromal cells from peritoneal dialysis effluent and comparison with those from human bone marrow and adipose tissue., PMID:37603218
Ravulizumab Can Effectively Treat Ischemic Enteritis Caused by Paroxysmal Nocturnal Hemoglobinuria., PMID:37558427
SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells., PMID:37322036
Canine Mammary Neoplasia Induces Variations in the Peripheral Blood Levels of CD20, CD45RA, and CD99., PMID:37298173
Unveiling CD59-Antibody Interactions to Design Paratope-Mimicking Peptides for Complement Modulation., PMID:37239905
A roadmap from research to clinical testing of mesenchymal stromal cell exosomes in the treatment of psoriasis., PMID:37115163
A simple method to differentiate three classes of cholesterol-dependent cytolysins., PMID:36898586
Daratumumab induces cell-mediated cytotoxicity of primary effusion lymphoma and is active against refractory disease., PMID:36632565
miR-132-3p regulates antibody-mediated complement-dependent cytotoxicity in colon cancer cells by directly targeting CD55., PMID:36571232
Knockdown of membrane-bound complement regulatory proteins suppresses colon cancer growth in mice through inducing tumor cell apoptosis., PMID:36446233
Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59., PMID:36359760
Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade., PMID:36271172
Dual targeting fixed duration frontline monoclonal antibody therapy for chronic lymphocytic leukemia: A phase 2 study., PMID:36115087
The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target., PMID:36110036
Serum peptidome profiles immune response of COVID-19 Vaccine administration., PMID:36091008
Optic neuritis in CD59 deficiency: an extremely rare presentation., PMID:36082655
Relationship between the expression of complement inhibitory proteins and therapeutic efficacy of antibodies in breast cancer., PMID:35894744
Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons., PMID:35784286
Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma., PMID:35725455
Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets., PMID:35666870
NANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59., PMID:35606403
Bispecific mAb2 Antibodies Targeting CD59 Enhance the Complement-Dependent Cytotoxicity Mediated by Rituximab., PMID:35563599
Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies., PMID:35517827
For research use only. Not for human or drug use.
