Anti-Human CD58/LFA3 Antibody (SAA0027)

Catalog No.

FHD33010

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

Surface glycoprotein LFA-3, Ag3, LFA3, Lymphocyte function-associated antigen 3, CD58

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P19256

Applications

FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA0027

Second generation CD2-targeting LFA-3 fusion protein SBT115301 to restore immune homeostasis in autoimmune disease., PMID:40491961

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency., PMID:40445758

Biological and Clinical Relevance of Genetic Alterations in Peripheral T-cell Lymphomas., PMID:40416001

Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface., PMID:40092189

Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes., PMID:40073269

Interim PET after 4 cycles predicts outcome in histomolecularly confirmed primary mediastinal B-cell lymphoma., PMID:40030008

From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes., PMID:39688401

CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa., PMID:39560648

[Efficacy and safety analysis of the OR-CHOP regimen for the treatment of MCD subtype diffuse large B cell lymphoma in the real-world setting]., PMID:39414605

Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans., PMID:39316441

Evolving Landscape of Biologic Therapy for Pediatric Psoriasis., PMID:38796269

HSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancer., PMID:38589927

A systematic review of case series and clinical trials investigating systemic oral or injectable therapies for the treatment of vitiligo., PMID:38454597

The influence of cytotoxic drugs on the immunophenotype of blast cells in paediatric B precursor acute lymphoblastic leukaemia., PMID:38378030

In Doxorubicin-Adapted Hodgkin Lymphoma Cells, Acquiring Multidrug Resistance and Improved Immunosuppressive Abilities, Doxorubicin Activity Was Enhanced by Chloroquine and GW4869., PMID:38067159

Genetic Characterization of Primary Mediastinal B-Cell Lymphoma: Pathogenesis and Patient Outcomes., PMID:38055913

NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG., PMID:37939134

Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes., PMID:37751304

Comprehensive cell surface protein profiling of human mesenchymal stromal cells from peritoneal dialysis effluent and comparison with those from human bone marrow and adipose tissue., PMID:37603218

Siplizumab combination therapy with belatacept or abatacept broadly inhibits human T cell alloreactivity in vitro., PMID:37270108

PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia., PMID:36516256

Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia., PMID:36451826

Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress., PMID:36353616

Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses., PMID:35881486

Human Oral Epithelial Cells Suppress T Cell Function via Prostaglandin E2 Secretion., PMID:35126344

CD18 Antibody Application Blocks Unwanted Off-Target T Cell Activation Caused by Bispecific Antibodies., PMID:34572822

Targeting pediatric leukemia-propagating cells with anti-CD200 antibody therapy., PMID:34470052

African Swine Fever Virus CD2v Protein Induces β-Interferon Expression and Apoptosis in Swine Peripheral Blood Mononuclear Cells., PMID:34452346

[Pathomorphological aspects of urethral strictures of various etiologies]., PMID:33960150

Proposal and validation of a method to classify genetic subtypes of diffuse large B cell lymphoma., PMID:33479306

Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects., PMID:33351781

CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes., PMID:33301420

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes., PMID:32833543

CD2 Immunobiology., PMID:32582179

Propagation of EBV-driven Lymphomatous Transformation of Peripheral Blood B Cells by Immunomodulators and Biologics Used in the Treatment of Inflammatory Bowel Disease., PMID:32322878

Immunophenotypic modulation in pediatric B lymphoblastic leukemia and its implications in MRD detection., PMID:32281503

Improved Recognition of Hematogones From Precursor B-Lymphoblastic Leukemia by a Single Tube Flow Cytometric Analysis., PMID:32068791

Immunophenotypic Characterization and Purification of Neoplastic Cells from Lymph Nodes Involved by T-Cell/Histiocyte-rich Large B-cell Lymphoma by Flow Cytometry and Flow Cytometric Cell Sorting., PMID:31254446

A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules., PMID:31110074

In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved Alefacept Can Selectively Target the Latent HIV Reservoir in CD4+ CD2hi Memory T Cells., PMID:30455699

Proximity ligation assay to study protein-protein interactions of proteins on two different cells., PMID:30227746

Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model., PMID:29904386

Natural Killer Cells Regulate Th17 Cells After Autologous Hematopoietic Stem Cell Transplantation for Relapsing Remitting Multiple Sclerosis., PMID:29867923

CD58; leucocyte function adhesion-3 (LFA-3) could be used as a differentiating marker between immune and non-immune thyroid disorders., PMID:29706856

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses., PMID:29691324

Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design., PMID:29459028

Dissecting the mechanisms involved in anti-human T-lymphocyte immunoglobulin (ATG)-induced tolerance in the setting of allogeneic stem cell transplantation - potential implications for graft versus host disease., PMID:29207601

Ibrutinib and idelalisib block immunophenotypic changes associated with the adhesion and activation of CLL cells in the tumor microenvironment., PMID:29164976

Diminished presentation of complement regulatory protein CD55 on red blood cells from patients with hereditary haemolytic anaemias., PMID:28963754

[Research Progress on Relationship between CD58 Molecule and ALL and Lymphoma -Review]., PMID:28446317

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