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Anti-Human CD42b/GP1BA Antibody (5G6)

Catalog #:   FHC25710 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1, kappa
Applications: FCM, WB
Accession: P07359
Overview

Catalog No.

FHC25710

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

CD42b, GP-Ib alpha, Antigen CD42b-alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, Platelet glycoprotein Ib alpha chain, GP1BA

Concentration

1.48 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P07359

Applications

FCM, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

5G6

Data Image
  • Bioactivity
    Detects CD42b/GP1BA in indirect ELISAs.
  • Flow-cytometry
    Flow-cytometry using anti-human CD42 antibody.Human peripheral blood monocytes were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD42 antibody monoclonal antibody (Catalog # FHC25710 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # PMB96441) and cells analysed on a NovoCyte Flow Cytometer.
References

CD19 chimeric antigen receptor-T cell therapy in murine immune thrombocytopenia., PMID:40139759

28-color single tube for flow cytometric assessment of myeloid maturation, myeloid neoplasia, and acute myeloid leukemia minimal/measurable residual disease., PMID:40134341

Preventative and therapeutic effects of a novel humanized anti-glycoprotein Ibα fragment of antigen-binding region in a murine model of thrombotic thrombocytopenic purpura., PMID:39956431

[Immunohistochemical method of megakaryocytic lineage staining in bone marrow biopsy specimens as an additional pathomorphological differential diagnostic sign of primary myelofibrosis and essential thrombocythemia]., PMID:39943725

A novel antibody against GPIbα inhibits platelet function and thrombosis without increasing bleeding., PMID:39924011

Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation., PMID:39738271

Ontogeny of the organized nasopharynx-associated lymphoid tissue in rainbow trout., PMID:39643071

The role of protein kinase C and the glycoprotein Ibα cytoplasmic tail in anti-glycoprotein Ibα antibody-induced platelet apoptosis and thrombocytopenia., PMID:39541612

Platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates., PMID:39499978

The effects of complement-independent, autoantibody-induced apoptosis of platelets in immune thrombocytopenia (ITP)., PMID:39271523

Platelet-Type von Willebrand Disease: Complex Pathophysiology and Insights on Novel Therapeutic and Diagnostic Strategies., PMID:39191406

Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy., PMID:39147240

Ramucirumab in second‑line advanced colorectal cancer therapy: A study on therapeutic outcomes and hepatic sinusoidal platelet aggregation., PMID:39081965

Nanobody activator improves sensitivity of the von Willebrand factor activity assay to multimer size., PMID:38704122

GPIbα CAAR T cells function like a Trojan horse to eliminate autoreactive B cells to treat immune thrombocytopenia., PMID:38299614

Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be Associated with Serum sIgE and Blood Eosinophil Levels in Chinese Patients with Allergic Diseases., PMID:38299390

Recombinantly Expressed Tagged SUrface Protein (RETSUP) assay: a new diagnostic system for the detection of antibodies to platelets., PMID:38184205

Anti-GPIb/IX autoantibodies are associated with poor response to dexamethasone combined with rituximab therapy in primary immune thrombocytopenia patients., PMID:37722393

Synergy by Ristocetin and CXCL12 in Human Platelet Activation: Divergent Regulation by Rho/Rho-Kinase and Rac., PMID:37298667

Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis., PMID:37279077

Thrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia., PMID:37259024

TMIGD1: Emerging functions of a tumor supressor and adhesion receptor., PMID:37087524

[Platelet adhesion mediated by von Willebrand factor in patients with premature coronary artery disease]., PMID:37061861

Serum from half of patients with immune thrombocytopenia trigger macrophage phagocytosis of platelets., PMID:37042934

Inhibition of CXCR1/2 reduces the emperipolesis between neutrophils and megakaryocytes in the Gata1low model of myelofibrosis., PMID:36863479

The association between platelet glycoprotein-specific antibodies and response to short-term high-dose dexamethasone with prednisone maintenance treatment in adult patients with primary immune thrombocytopenia., PMID:36799363

von Willebrand factor neutralizing and non-neutralizing alloantibodies in 213 subjects with type 3 von Willebrand disease enrolled in 3WINTERS-IPS., PMID:36792472

Immune-mediated platelet depletion augments Alzheimer's disease neuropathological hallmarks in APP-PS1 mice., PMID:36734880

Identification of platelet subpopulations in cryopreserved platelet components using multi-colour imaging flow cytometry., PMID:36681723

Abnormal platelet immunophenotypes and percentage of giant platelets in myelodysplastic syndrome: A pilot study., PMID:36409726

Anti-glycoprotein autoantibodies are related to bleeding severity in children with newly diagnosed ITP and very low platelet counts., PMID:36377718

Single and Multiplex Immunohistochemistry to Detect Platelets and Neutrophils in Rat and Porcine Tissues., PMID:36136817

Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice., PMID:36090760

Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper Bitis arietans, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen., PMID:35448845

Acute drug-induced immune thrombocytopenia - A work of articaine., PMID:35305268

Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti-GPIbβ antibody derivative., PMID:35305057

Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear., PMID:35216161

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia., PMID:35199503

The impact of aberrant von Willebrand factor-GPIbα interaction on megakaryopoiesis and platelets in humanized type 2B von Willebrand disease model mouse., PMID:35142156

Evaluation of Endothelial Dysfunction and Inflammatory Vasculopathy After SARS-CoV-2 Infection-A Cross-Sectional Study., PMID:34722682

Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models., PMID:34657336

Anti-glycoprotein antibodies and sequestration pattern of indium-labeled platelets in immune thrombocytopenia., PMID:34654052

Performance characteristics of platelet autoantibody testing for the diagnosis of immune thrombocytopenia using strict clinical criteria., PMID:34109621

In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα., PMID:34083615

Platelet autoantibody specificity and response to rhTPO treatment in patients with primary immune thrombocytopenia., PMID:33993469

Differential regulation of the platelet GPIb-IX complex by anti-GPIbβ antibodies., PMID:33915031

Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3., PMID:33556295

A fibrinolytic snake venom metalloproteinase, mutalysin-II, with antiplatelet activity and targeting capability toward glycoprotein GPIbα and glycoprotein GPVI., PMID:33548391

Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury., PMID:33437573

Influence of long-term proteasome inhibition on platelet responsiveness mediated by bortezomib., PMID:33422688

Datasheet
$ 165
Product specifications
50 μg 165 100 μg 272

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Anti-Human CD42b/GP1BA Antibody (5G6) [FHC25710]
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