Anti-Human CD318/CDCP1 Antibody (CUB4)

Catalog No.

FHJ57510

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

CD318, Transmembrane and associated with src kinases, TRASK, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Membrane glycoprotein gp140, CUB domain-containing protein 1, CDCP1

Concentration

2.12 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9H5V8

Applications

FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

CUB4

Itolizumab regulates activating and inhibitory signals on effector cells, improving their cytotoxicity against CD318+ tumor cell lines., PMID:40391211

Receptor CDCP1 Is a Potential Target for Personalized Imaging and Treatment of Poor Outcome HER2+, Triple-Negative, and Metastatic ER+/HER2- Breast Cancers., PMID:39869307

Quantitative Membrane Proteomics for Discovery of Actionable Drug Targets at the Surface of RAS-Driven Human Cancer Cells., PMID:39052212

Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells., PMID:38280067

CD6 and Its Interacting Partners: Newcomers to the Block of Cancer Immunotherapies., PMID:38139340

Activation of Cytotoxic Lymphocytes Through CD6 Enhances Killing of Cancer Cells., PMID:37886483

Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer., PMID:37468417

Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer., PMID:36648492

Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress., PMID:36353616

CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy., PMID:36276654

CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease., PMID:35604681

Antibodies Against Cleaved CDCP1 Show Activity in RAS-Mutant Tumors., PMID:35373280

Cleaved CDCP1 marks the spot: a neoepitope for RAS-driven cancers., PMID:35166242

Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer., PMID:34621145

Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer., PMID:34448393

Contemporary Lung Cancer Screening and the Promise of Blood-Based Biomarkers., PMID:34252039

CD6 is a target for cancer immunotherapy., PMID:33497367

Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer-Letter., PMID:33060289

Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer., PMID:32341034

Attenuation of Murine Collagen-Induced Arthritis by Targeting CD6., PMID:32307907

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma., PMID:32226543

CUB Domain-containing Protein 1 (CDCP1) Is Down-regulated by Active Hexose-correlated Compound in Human Pancreatic Cancer Cells., PMID:30396925

Clinical and experimental evidence for targeting CD6 in immune-based disorders., PMID:29526637

Hepatic stem cells with self-renewal and liver repopulation potential are harbored in CDCP1-positive subpopulations of human fetal liver cells., PMID:29402311

Expression of CDCP1 and ADAM12 in the ovarian cancer microenvironment., PMID:27685922

Cell-Surface Protein Profiling Identifies Distinctive Markers of Progenitor Cells in Human Skeletal Muscle., PMID:27509136

CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment., PMID:27495374

Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer., PMID:26882065

Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer., PMID:26497208

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling., PMID:26227951

Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance., PMID:25893298

Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer., PMID:25892239

The tyrosine phosphatase SHP2 associates with CUB domain-containing protein-1 (CDCP1), regulating its expression at the cell surface in a phosphorylation-dependent manner., PMID:25876044

CDCP1 identifies a CD146 negative subset of marrow fibroblasts involved with cytokine production., PMID:25275584

EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface., PMID:24681947

Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer., PMID:24260357

Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy., PMID:24055141

Structural requirements for cub domain containing protein 1 (CDCP1) and Src dependent cell transformation., PMID:23300860

In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling., PMID:23208492

Stratum basale keratinocyte expression of the cell-surface glycoprotein CDCP1 during epidermogenesis and its role in keratinocyte migration., PMID:23121233

Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers., PMID:23105007

The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration., PMID:22315226

Infrared spectral signatures of CDCP1-induced effects in colon carcinoma cells., PMID:22034616

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells., PMID:21804561

The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility., PMID:21725358

CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis., PMID:21220330

Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1., PMID:19916495

Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination., PMID:19671673

The transmembrane src substrate Trask is an epithelial protein that signals during anchorage deprivation., PMID:19349359

Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model., PMID:18483259

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