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Anti-Human CD317/BST2 Antibody (HM1.24)

Catalog #:   FHG26710 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1, kappa
Applications: FCM
Accession: Q10589
Overview

Catalog No.

FHG26710

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

Tetherin, Bone marrow stromal antigen 2, BST2, BST-2, CD317, HM1.24 antigen

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q10589

Applications

FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

HM1.24

Data Image
  • Bioactivity
    Detects CD317/BST2 in indirect ELISAs.
  • Flow-cytometry
    Flow-cytometry using anti-human CD317 antibody.Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD317 antibody monoclonal antibody (Catalog # FHG26710 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # PMB96441) and cells analysed on a NovoCyte Flow Cytometer.
  • Flow-cytometry
    Flow-cytometry using anti-human CD317 antibody.Human peripheral blood lymphocytes were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD317 antibody monoclonal antibody (Catalog # FHG26710 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # PMB96441) and cells analysed on a NovoCyte Flow Cytometer.
References

Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers., PMID:39718725

Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin., PMID:38190411

Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin., PMID:37858466

Chimeric antigen receptor T cell-based targeting of CD317 as a novel immunotherapeutic strategy against glioblastoma., PMID:37335916

The roles of BST-2 in murine B cell development and on virus propagation., PMID:36604771

OMIP-088: Twenty-target imaging mass cytometry panel for major cell populations in mouse formalin fixed paraffin embedded liver., PMID:36602064

Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients., PMID:35081977

Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells., PMID:34890590

Plasmacytoid dendritic cells promote the pathogenesis of Sjögren's syndrome., PMID:34780913

CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity., PMID:33785592

A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma., PMID:33753855

Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis., PMID:33150680

CD319 (SLAMF7) an alternative marker for detecting plasma cells in the presence of daratumumab or elotuzumab., PMID:33017079

Antibody development and property analysis of RhBST2 for accurate cell biological and viral research., PMID:32681953

The Nef Protein of the Macrophage Tropic HIV-1 Strain AD8 Counteracts Human BST-2/Tetherin., PMID:32325729

Mass Cytometry Analysis Reveals Complex Cell-State Modifications of Blood Myeloid Cells During HIV Infection., PMID:31824485

pDC depletion induced by CD317 blockade drives the antitumor immune response in head and neck squamous cell carcinoma., PMID:31422204

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses., PMID:31213558

CD317 Activates EGFR by Regulating Its Association with Lipid Rafts., PMID:30890618

Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner., PMID:30759394

Aberrant expression of the innate restriction factor bone marrow stromal antigen-2 in primary Sjögren's syndrome., PMID:30249485

Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice., PMID:30219230

T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool., PMID:30201960

CD317 Signature in Head and Neck Cancer Indicates Poor Prognosis., PMID:29486141

Single-cell analysis identifies cellular markers of the HIV permissive cell., PMID:29073251

BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity., PMID:28331088

Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-infected T cells to ADCC Mediated by Broadly Neutralizing Antibodies., PMID:27853288

The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies., PMID:27707924

Tetherin Antagonism by HIV-1 Group M Nef Proteins., PMID:27654287

Monoclonal Antibody Against Bone Marrow Stromal Cell Antigen 2 Protein of Swine., PMID:27328062

Tetherin/BST-2: Restriction Factor or Immunomodulator?, PMID:26957198

CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody., PMID:26498112

Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors., PMID:26317613

Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge., PMID:26311886

Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity., PMID:26269175

Stress-activated Dendritic Cells (DC) Induce Dual Interleukin (IL)-15- and IL1β-mediated Pathways, Which May Elicit CD4+ Memory T Cells and Interferon (IFN)-stimulated Genes., PMID:25907558

The novel multispecies Fc-specific Pseudomonas exotoxin A fusion protein α-Fc-ETA' enables screening of antibodies for immunotoxin development., PMID:25701195

The role of HIV-specific antibody-dependent cellular cytotoxicity in HIV prevention and the influence of the HIV-1 Vpu protein., PMID:25396265

Targeted therapy for HM1.24 (CD317) on multiple myeloma cells., PMID:25143955

The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells., PMID:24927408

Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity., PMID:24733916

HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells., PMID:24623433

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2., PMID:24498878

Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors., PMID:24386306

Tactics used by HIV-1 to evade host innate, adaptive, and intrinsic immunities., PMID:23786957

Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo., PMID:23185591

Characterization of 5C11-positive activated interferon-producing cells in patients with systemic lupus erythematosus., PMID:23087259

Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer., PMID:22729361

Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function., PMID:22246035

Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction., PMID:22194693

Datasheet
$ 225
Product specifications
50 μg 225 100 μg 372

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For research use only. Not for human or drug use.

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Anti-Human CD317/BST2 Antibody (HM1.24) [FHG26710]
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