Catalog No.
FHE78010
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
Apo-2 ligand, CD253, Tumor necrosis factor ligand superfamily member 10, TRAIL, APO2L, TNFSF10, Protein TRAIL, Apo-2L, TNF-related apoptosis-inducing ligand
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P50591
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0079
Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins., PMID:39740038
The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL., PMID:39365855
Evaluating TRAIL and IP-10 alterations in vaccinated pregnant women after COVID-19 diagnosis and their correlation with neutralizing antibodies., PMID:39290698
Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement., PMID:38562920
Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices., PMID:36901724
Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma., PMID:34946664
BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-κB in NSCLC., PMID:34400879
IL13Rα2‑ and EGFR‑targeted pseudomonas exotoxin potentiates the TRAIL‑mediated death of GBM cells., PMID:34080646
NCTR25 fusion facilitates the formation of TRAIL polymers that selectively activate TRAIL receptors with higher potency and efficacy than TRAIL., PMID:33942150
Interleukin-6 sensitizes TNF-α and TRAIL/Apo2L dependent cell death through upregulation of death receptors in human cancer cells., PMID:33839168
TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration., PMID:33806288
Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas., PMID:33737574
Highly activated TRAIL+ CD56bright NK cells are associated with the liver damage in HBV-LC patients., PMID:33515618
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy., PMID:33483421
Revisiting the role of TRAIL/TRAIL-R in cancer biology and therapy., PMID:33401962
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells., PMID:33229588
Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells., PMID:32669373
Adipose Tissue-Derived Mesenchymal Stem Cells Suppress Growth of Huh7 Hepatocellular Carcinoma Cells via Interferon (IFN)-β-Mediated JAK/STAT1 Pathway in vitro., PMID:32210710
Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TRAIL-resistant Tumor Cells., PMID:32156787
Curcumin augments therapeutic efficacy of TRAIL-based immunotoxins in leukemia., PMID:32141025
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL., PMID:31676378
TRAIL Mediated Signaling in Breast Cancer: Awakening Guardian Angel to Induce Apoptosis and Overcome Drug Resistance., PMID:31456187
TRAIL responses are enhanced by nuclear export inhibition in osteosarcoma., PMID:31362889
Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy., PMID:31266830
A New Efficient Method for Production of Recombinant Antitumor Cytokine TRAIL and Its Receptor-Selective Variant DR5-B., PMID:31238862
TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection., PMID:31189571
Dihydrotestosterone Increases Cytotoxic Activity of Macrophages on Prostate Cancer Cells via TRAIL., PMID:31184711
HIV elite control is associated with reduced TRAILshort expression., PMID:31149947
ZBTB24 regulates the apoptosis of human T cells via CDCA7/TRAIL-receptor axis., PMID:31030944
Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells., PMID:30947287
TRAIL receptor activation overcomes resistance to trastuzumab in HER2 positive breast cancer cells., PMID:30928382
Apoptosis in patients with primary antiphospholipid antibody syndrome., PMID:30729698
Silica cloaking of adenovirus enhances gene delivery while reducing immunogenicity., PMID:30690106
Elucidation for modulation of death receptor (DR) 5 to strengthen apoptotic signals in cancer cells., PMID:30632113
The expression of death receptor systems TRAIL-R1/-R2/-R4, CD95 and TNF-R1 and their cognate ligands in pancreatic ductal adenocarcinoma., PMID:30375637
Association Between C1q, TRAIL, and Tim-1 Gene Polymorphisms and Systemic Lupus Erythematosus., PMID:30183357
MG-132 treatment promotes TRAIL-mediated apoptosis in SEB-1 sebocytes., PMID:30176247
Endogenous IgG-based affinity-controlled release of TRAIL exerts superior antitumor effects., PMID:29721092
The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells., PMID:29670075
The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells., PMID:29661248
Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression., PMID:29593282
Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment., PMID:29263214
TNF-related apoptosis-inducing ligand (TRAIL) for bone sarcoma treatment: Pre-clinical and clinical data., PMID:28888998
Anti-interleukin-6 signalling therapy rebalances the disrupted cytokine production of B cells from patients with active rheumatoid arthritis., PMID:28850672
Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo., PMID:28827692
Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma., PMID:28799237
ERK1/2-mediated Cytoplasmic Accumulation of hnRNPK Antagonizes TRAIL-induced Apoptosis through Upregulation of XIAP in H1299 Cells., PMID:28756806
A novel humanized anti-tumor necrosis factor-related apoptosis-inducing ligand-R2 monoclonal antibody induces apoptotic and autophagic cell death., PMID:28748573
Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the in vivo Antitumor Effects of Human TRAIL., PMID:28740549
TRAIL-NP hybrids for cancer therapy: a review., PMID:28443893
For research use only. Not for human or drug use.
