Catalog No.
FHD30420
Species reactivity
Human
Host species
Human
Isotype
IgG4, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
FDC, LAG3, Lymphocyte activation gene 3 protein, CD223, sLAG-3, LAG-3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P18627
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0073
CD200R activation on naïve T cells by B cells induces suppressive activity of T cells via IL-24., PMID:38780647
Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers., PMID:38734740
Clinical Significance of Soluble LAG-3 (sLAG-3) in Patients With Cervical Cancer Determined via Enzyme-Linked Immunosorbent Assay With Monoclonal Antibodies., PMID:37968933
LAG-3 transcriptomic expression patterns across malignancies: Implications for precision immunotherapeutics., PMID:37132280
Suppression of Streptococcosis and Modulation of the Gut Bacteriome in Nile Tilapia (Oreochromis niloticus) by the Marine Sediment Bacteria Bacillus haynesii and Advenella mimigardefordensis., PMID:36453920
Epitope Mapping of Therapeutic Antibodies Targeting Human LAG3., PMID:36104110
Research Progress Concerning Dual Blockade of Lymphocyte-Activation Gene 3 and Programmed Death-1/Programmed Death-1 Ligand-1 Blockade in Cancer Immunotherapy: Preclinical and Clinical Evidence of This Potentially More Effective Immunotherapy Strategy., PMID:33488573
Development of a 43 color panel for the characterization of conventional and unconventional T-cell subsets, B cells, NK cells, monocytes, dendritic cells, and innate lymphoid cells using spectral flow cytometry., PMID:33336868
[Next generation of anti-immune checkpoints antibodies]., PMID:31903901
Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation., PMID:30792213
Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer., PMID:30179225
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells., PMID:29553498
Co-inhibitory profile and cytotoxicity of CD57+ PD-1- T cells in end-stage renal disease patients., PMID:29027667
LAG3 (CD223) as a cancer immunotherapy target., PMID:28258692
Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for the restoration of active antitumor immunity., PMID:25941596
Prenatal cadmium exposure alters postnatal immune cell development and function., PMID:22521604
MHC class II engagement by its ligand LAG-3 (CD223) contributes to melanoma resistance to apoptosis., PMID:21441454
Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+) )-activated T lymphocytes prevents delayed-type hypersensitivity in non-human primates., PMID:21352204
Soluble pig lymphocyte activation gene-3 (LAG-3; CD223) inhibits human-to-pig xenogeneic mixed lymphocyte reaction., PMID:19834647
Depletion of LAG-3 positive cells in cardiac allograft reveals their role in rejection and tolerance., PMID:18091527
IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study., PMID:17394654
Soluble CD30 and lymphocyte activation gene-3 (CD223), as potential serological markers of T helper-type cytokine response induced by acellular pertussis vaccine., PMID:16569347
Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells., PMID:15971272
The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells., PMID:15885122
LAG-3 (CD223) reduces macrophage and dendritic cell differentiation from monocyte precursors., PMID:15720438
Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223)., PMID:15634887
MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223)., PMID:12775570
LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice., PMID:12750275
Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3)., PMID:12209638
For research use only. Not for human or drug use.
