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Anti-Human CD18/ITGB2 Antibody (SAA2180)

Catalog #:   FHC13120 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG
Applications: FCM
Accession: P05107
Overview

Catalog No.

FHC13120

Species reactivity

Human

Host species

Human

Isotype

IgG

Clonality

Monoclonal

Conjugation

Unconjugated

Target

Complement receptor C3 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Integrin beta-2, MFI7, CD18, ITGB2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05107

Applications

FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA2180

Data Image
References

PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance., PMID:40512837

Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells., PMID:40381622

MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases., PMID:40312574

ICAM-1/CD18-mediated sequestration of parasitized phagocytes in cortical capillaries promotes neuronal colonization by Toxoplasma gondii., PMID:40229286

Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells., PMID:39885580

Dual in vivo T cell depleted haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and anti-thymocyte globulin as a third salvage transplant for leukocyte adhesion deficiency with graft failure: a case report., PMID:39845947

Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice., PMID:39841806

Humanized anti-CD11d monoclonal antibodies suitable for basic research and therapeutic applications., PMID:39839909

Mechanisms of Mt.b Ag85B-Fc fusion protein against allergic asthma in mice by intranasal immunization., PMID:39549815

Targeting Human Pancreatic Cancer with a Fluorophore-Conjugated Mucin 4 (MUC4) Antibody: Initial Characterization in Orthotopic Cell Line Mouse Models., PMID:39458160

Flow cytometric-based detection of CD80 is a useful diagnostic marker of acute myeloid leukemia in dogs., PMID:39224452

Sarcomas of synovial origin in dogs: An updated review., PMID:39068516

CD47-SIRPα Blockade Sensitizes Head and Neck Squamous Cell Carcinoma to Cetuximab by Enhancing Macrophage Adhesion to Cancer Cells., PMID:38959336

Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice., PMID:38899470

Flow cytometric analysis of immune cell populations in the bronchial and mesenteric lymph nodes of the dromedary camel., PMID:38746932

Melan-A immunolabeling in canine extramedullary plasmacytomas., PMID:38642035

The monocyte cell surface is a unique site of autoantigen generation in rheumatoid arthritis., PMID:38630712

SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function., PMID:38487529

The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia., PMID:38454605

A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs., PMID:38372326

SIGLEC-5/14 Inhibits CD11b/CD18 Integrin Activation and Neutrophil-Mediated Tumor Cell Cytotoxicity., PMID:38138970

Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report., PMID:38012597

Neutrophil attachment via Mac-1 (αMβ2; CD11b/CD18; CR3) integrins induces PAD4 deimination of profilin and histone H3., PMID:37778386

Polymorphonuclear phenotypical expression of CD18, at baseline and after in vitro activation, in several clinical disorders: Revision of our case series., PMID:37482987

Regulation of coagulation activation in newly diagnosed AML by the heme enzyme myeloperoxidase., PMID:37473552

Mechano-Redox Control of Mac-1 De-Adhesion by PDI Promotes Directional Movement Under Flow., PMID:37021588

Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15., PMID:36944397

Allosteric targeting resolves limitations of earlier LFA-1 directed modalities., PMID:36921634

Phagocytosis via complement receptor 3 enables microbes to evade killing by neutrophils., PMID:36882066

CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization., PMID:36822392

Phenotyping and Genotyping of HNA: Prevalence, Risk of Alloimmunization, and HNA Incompatibilities in Indians., PMID:36818775

The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation., PMID:36796515

Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative Vitreoretinopathy., PMID:36723927

Neutrophil function following treatment of psoriatic arthritis patients with secukinumab: altered cytokine signalling but no impairment of host defence., PMID:36617171

In-depth immunophenotyping reveals significant alteration of lymphocytes in buffalo with brucellosis., PMID:36602043

Immunosuppressive Effects of Annona muricata L. Leaf Extract on Cellular and Humoral Immune Responses in Male Wistar Rats., PMID:36545731

Integrin CD11b Contributes to Hypertension and Vascular Dysfunction Through Mediating Macrophage Adhesion and Migration., PMID:36377602

Undifferentiated Wing Sarcoma in a Peach-Faced Lovebird (Agapornis roseicollis)., PMID:36335863

High-Dimensional Cytometry Dissects Immunological Fingerprints of Idiopathic Inflammatory Myopathies., PMID:36291195

Characterization of microglia/macrophage phenotypes in the spinal cord following intervertebral disc herniation., PMID:36262531

B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury., PMID:36210579

β2-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response., PMID:36139397

Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin., PMID:35977491

Flow Cytometric Analysis of Leukocyte Populations in the Lung Tissue of Dromedary Camels., PMID:35737339

Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex., PMID:35728876

CD18 Mediates Neutrophil Imperviousness to the Aggregatibacter actinomycetemcomitans JP2 Clone in Molar-Incisor Pattern Periodontitis., PMID:35663998

A humanized β2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivo., PMID:35649374

Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation., PMID:35563841

Using digital RNA counting to establish flow cytometry diagnostic criteria for subtypes of CD34+ canine acute leukaemia., PMID:35491468

Monocytes augment inflammatory responses in human aortic valve interstitial cells via β2-integrin/ICAM-1-mediated signaling., PMID:35411432

Datasheet
$ 198
Product specifications
50 μg 198 100 μg 328

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For research use only. Not for human or drug use.

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Anti-Human CD18/ITGB2 Antibody (SAA2180) [FHC13120]
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