Catalog No.
FHG15810
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, EDDR1, CAK, Tyrosine kinase DDR, Mammary carcinoma kinase 10, TRKE, Epithelial discoidin domain-containing receptor 1, CD167a, TRK E, Epithelial discoidin domain receptor 1, HGK2, CD167 antigen-like family member A, NEP, MCK-10, Tyrosine-protein kinase CAK, PTK3A, DDR1, Discoidin receptor tyrosine kinase, RTK6, Cell adhesion kinase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08345
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
2004#
The role of DDR1 in cancer and the progress of its selective inhibitors., PMID:39642752
Antibody-drug conjugates targeting DDR1 as a novel strategy for treatment of breast cancer., PMID:39072640
Clinical significance of immunohistochemical expression of DDR1 and β-catenin in colorectal carcinoma., PMID:37271822
New target DDR1: A "double-edged sword" in solid tumors., PMID:36356724
Discoidin domain receptor 1 is a potential target correlated with tumor invasion and immune infiltration in gastric cancer., PMID:35935941
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion., PMID:34732895
Ultrastructural Location and Interactions of the Immunoglobulin Receptor Binding Sequence within Fibrillar Type I Collagen., PMID:32545195
DDR1 promotes breast tumor growth by suppressing antitumor immunity., PMID:31578591
Live cell measurements of interaction forces and binding kinetics between Discoidin Domain Receptor 1 (DDR1) and collagen I with atomic force microscopy., PMID:31351093
Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma., PMID:31116512
Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice., PMID:29298894
Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1., PMID:26719540
Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic., PMID:25621729
Collagen recognition and transmembrane signalling by discoidin domain receptors., PMID:23128141
Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling., PMID:22483115
Discoidin domain receptor 1 contributes to eosinophil survival in an NF-kappaB-dependent manner in Churg-Strauss syndrome., PMID:16968898
Activation of discoidin domain receptor 1 on CD14-positive bronchoalveolar lavage fluid cells induces chemokine production in idiopathic pulmonary fibrosis., PMID:15879152
Reactivity of new adhesion molecules on lymphocytes from patients with chronic graft versus host disease., PMID:12793201
Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by alpha2beta1 integrin., PMID:12676963
Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion., PMID:12471617
Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices., PMID:10750585
Protein kinase C inhibits the CAK-CDK2 cyclin-dependent kinase cascade and G1/S cell cycle progression in human diploid fibroblasts., PMID:9244189
For research use only. Not for human or drug use.
