Catalog No.
FHD85420
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
sCD40L, Tumor necrosis factor ligand superfamily member 5, T-cell antigen Gp39, CD40L, TNFSF5, CD154, CD40-L, TNF-related activation protein, CD40 ligand, CD40LG, TRAP
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29965
Applications
FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
5C8
Advances in Subclinical and Clinical Trials and Immunosuppressive Therapies in Xenotransplantation., PMID:40387233
Platelet-Derived Soluble CD40L and Its Impact on Immune Modulation and Anti-IL6R Antibody Treatment Outcome in Rheumatoid Arthritis., PMID:40358149
Case Report: Co-occurrence of tubulitis and SARS-CoV-2 specific T-cells in a kidney transplant recipient., PMID:40343198
Desensitization With Proteasome Inhibition and Costimulation Blockade Modulates the Xenoreactive Humoral Response in Nonhuman Primate Xenotransplantation., PMID:40259710
LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity., PMID:40246582
The T-cell response to SARS-CoV- 2 vaccination persists beyond six months in rheumatoid arthritis patients treated with rituximab., PMID:40241223
OMIP-113: Characterization of Cytokine Producing T Cells in Swine., PMID:40231482
Recognition of different subsets of alloreactive T cells by activation-induced markers., PMID:40204006
International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation., PMID:40198240
International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation., PMID:40197435
CAR Treg synergy with anti-CD154 promotes infectious tolerance and dictates allogeneic heart transplant acceptance., PMID:40197364
Targeted immunotherapies for Graves' thyroidal & orbital diseases., PMID:40145088
Extensive T-Cell Profiling Following SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis Patients Treated with DMTs., PMID:40137720
Lupenone preserves T cell activity by recovery of CD40L expression and protection from cytotoxicity due to methamphetamine exposure., PMID:40111983
Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement., PMID:40090010
Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors., PMID:40074330
Influence of environmental exposures on T follicular helper cell function and implications on immunity: a comparison of Bangladeshi and American children., PMID:40062864
Transition from preclinical to clinical application of CTLA4-Ig co-stimulation blockage in beta-cell replacement therapy., PMID:40048867
Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: enhanced immune response in piglets with CD154 molecules., PMID:40046411
Modified CD40L-Activated B-Cell Proliferation Model for Validating the Suppressive Activity of CD40-CD154 Pathway Inhibitors., PMID:39994946
CD40 induces PIR-A+ macrophages to promote chronic allograft rejection., PMID:39954660
Discrimination of Anti-Donor Response in Allogeneic Transplantation Using an Alloreactive T-Cell Detection Assay., PMID:39936124
Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors., PMID:39924119
Precise identification and tracking of HMGCR-reactive CD4+ T cells in the target tissue of patients with anti-HMGCR immune-mediated necrotising myopathy., PMID:39919903
A New PD-L1 Nanobody Enhances Cell Death in Lung Cancer In Vitro and In Vivo., PMID:39890194
Prolonged pediatric intensive care unit (PICU) admission, challenges in diagnosis and treatment in a child with hyper IgM syndrome in a tertiary hospital in Tanzania: a case report., PMID:39886113
CD40 ligand and CD40: expression, regulation and function at the maternal-conceptus interface in pigs., PMID:39874127
The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation., PMID:39872238
CD40 Ligand Potentiates Immunogenecity of Mycoplasma pneumoniae Subunit Vaccine Candidate in a Murine Model., PMID:39852152
Enhanced Costimulation Blockade With αCD154, αCD2, and αCD28 to Promote Heart Allograft Tolerance in Nonhuman Primates., PMID:39792548
Clinical and immunological outcomes after randomized trial of baked milk oral immunotherapy for milk allergy., PMID:39782691
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer., PMID:39763802
CD154 blockade effectively controls antibody-mediated rejection in highly sensitized nonhuman primate kidney transplant recipients., PMID:39742504
Personalized Multi-Epitope Nanovaccine Unlocks B Cell-Mediated Multiple Pathways of Antitumor Immunity., PMID:39711226
Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy., PMID:39693719
Small-molecule inhibitors of the CD40-CD40L costimulatory interaction are effective in pancreatic islet transplantation and prevention of type 1 diabetes models., PMID:39606229
Comprehensive serum biomarker analysis reveals IL-8 changes as the only predictor of the effectiveness of immune checkpoint inhibitors for patients with advanced non-small cell lung cancer., PMID:39571250
Mechanotransduction governs CD40 function and underlies X-linked hyper-IgM syndrome., PMID:39546606
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus., PMID:39511302
Dissecting immunological mechanisms underlying influenza viral nucleoprotein-induced mucosal immunity against diverse viral strains., PMID:39508450
Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial., PMID:39480764
Induction of an immune response by a nonreplicating adenoviruses-based formulation versus a commercial pseudo-SARS-CoV-2 vaccine., PMID:39439719
Implications of CD154 and Its Receptors in the Pathogenesis and Treatment of Systemic Lupus Erythematosus., PMID:39404385
CAR Treg synergy with anti-CD154 mediates infectious tolerance to dictate heart transplant outcomes., PMID:39386649
42-parameter mass cytometry panel to assess cellular and functional phenotypes of leukocytes in bronchoalveolar lavage of Rhesus macaque., PMID:39386621
Modulating Immune Responses: The Double-Edged Sword of Platelet CD40L., PMID:39379039
Pig-to-human kidney xenotransplants using genetically modified minipigs., PMID:39317190
Lipid nanoparticle encapsulation of a Delta spike-CD40L DNA vaccine improves effectiveness against Omicron challenge in Syrian hamsters., PMID:39309757
Preschool-age children maintain a distinct memory CD4+ T cell and memory B cell response after SARS-CoV-2 infection., PMID:39292802
Antigen-specific T helper cells and cytokine profiles predict intensity and longevity of cellular and humoral responses to SARS-CoV-2 booster vaccination., PMID:39267758
For research use only. Not for human or drug use.
