Catalog No.
FHE39720
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CD146, Melanoma cell adhesion molecule, S-endo 1 endothelial-associated antigen, Melanoma-associated antigen A32, MUC18, MCAM, Melanoma-associated antigen MUC18, Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12
Concentration
0.7 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P43121
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0060
[Correlation between soluble CD146 and systemic vasculitis]., PMID:40484821
A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells., PMID:40316673
Extracellular Vesicles Analysis as Possible Signatures of Antiphospholipid Syndrome Clinical Features., PMID:40243411
Involvement of CD146 in the Cryptococcus neoformans adhesion and infection of brain endothelial cells., PMID:40208055
Antigen targeting and anti-tumor activity of a novel anti-CD146 212Pb internalizing alpha-radioimmunoconjugate against malignant peritoneal mesothelioma., PMID:39472474
Hepatic Stellate Cell-mediated Increase in CCL5 Chemokine Expression after X-ray Irradiation Determined In Vitro and In Vivo., PMID:39449628
Soluble CD146 Cooperates with VEGFa to Generate an Immunosuppressive Microenvironment in CD146-Positive Tumors: Interest of a Combined Antibody-Based Therapy., PMID:39431288
Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling., PMID:39309216
The Blood-Brain Barrier in Both Humans and Rats: A Perspective From 3D Imaging., PMID:39224835
Preclinical ImmunoPET Imaging Using a Zr-89-Labeled Anti-CD146 Monoclonal Antibody for Diagnosis of Melanoma., PMID:39077827
CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway., PMID:38908086
Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer., PMID:38902710
An immune sandwich electrochemical biosensor based on triple-modified zirconium derivatives for detection of CD146 in serum., PMID:38599037
Evaluation of Circulating Endothelial Cells as Direct Marker of Endothelial Damage in Allo-Transplant Recipients at High Risk of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome., PMID:38582286
Plasma sCD146 is a potential biomarker for acute exacerbation of chronic obstructive pulmonary disease., PMID:38476031
Exploring the Utility of Circulating Endothelial Cell-Derived Extracellular Vesicles as Markers of Health and Damage of Vasal Endothelium in Systemic Sclerosis Patients Treated with Iloprost., PMID:38397897
CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages., PMID:38109838
CD146-targeted nuclear medicine imaging in cancer: state of the art., PMID:38076327
CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway., PMID:37856423
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization., PMID:37749499
CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis., PMID:37650914
Prognostic significance of circulating microparticles in IgA nephropathy., PMID:37615844
Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity., PMID:37484769
Regeneration of periodontal ligament fibers around mini dental implants and their attachment to the bone in an animal model: A radiographic and histological study., PMID:37152460
Microcirculation surrounding end-stage human chronic skin wounds is associated with endoglin/CD146/ALK-1 expression, endothelial cell proliferation and an absence of p16Ink4a., PMID:37017097
Neuroblastoma Tumor-Associated Mesenchymal Stromal Cells Regulate the Cytolytic Functions of NK Cells., PMID:36612020
Microvesicles released from ectopic endometrial foci as a potential biomarker of endometriosis., PMID:36448351
MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes., PMID:36319587
Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma., PMID:36274147
Immunotherapeutic Targeting of NG2/CSPG4 in Solid Organ Cancers., PMID:35891187
Exercise Training Effects on Circulating Endothelial and Progenitor Cells in Heart Failure., PMID:35877584
Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry., PMID:35716258
Soluble CD146 is increased in preeclampsia and interacts with galectin-1 to regulate trophoblast migration through VEGFR2 receptor., PMID:35559998
Minimal Cube Explant Provides Optimal Isolation Condition of Mesenchymal Stem Cells from Umbilical Cord., PMID:35325405
The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia., PMID:35306530
CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity., PMID:35258174
Cell Surface Proteins for Enrichment and In Vitro Characterization of Human Pluripotent Stem Cell-Derived Myogenic Progenitors., PMID:35251185
Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination., PMID:35055160
Involvement of Multiple Variants of Soluble CD146 in Systemic Sclerosis: Identification of a Novel Profibrotic Factor., PMID:35001552
Comprehensive Immune Profiling Reveals CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease., PMID:34987111
Proliferation rate and expression of stem cells markers during expansion in primary culture of pulp cells., PMID:34878083
CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases., PMID:34729700
Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells., PMID:34611477
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4., PMID:34575887
CD146 is a potential immunotarget for neuroblastoma., PMID:34464480
Isolation and immunohistochemical characterization of periodontal ligament stem cells: A preliminary study., PMID:34393399
Recognize the role of CD146/MCAM in the osteosarcoma progression: an in vitro study., PMID:34103063
Differential expression of P63, P27, P57, Ki-67, and CD146 in hydropic and molar pregnancies., PMID:34057923
Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146., PMID:33997697
ImmunoPET of the differential expression of CD146 in breast cancer., PMID:33948375
For research use only. Not for human or drug use.
