Catalog No.
FHC36920
Species reactivity
Human
Host species
Human
Isotype
IgG2, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P08887
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0049
Anti-IL-6R antibody treatment changes microglial phenotype in AQP4 peptide-immunized mice, leading to suppression of myelitis severity., PMID:40403514
Anti-IL-6 receptor antibody suppresses onset of paralytic symptoms in AQP4 peptide-immunized mice without lowering bone strength or mineral density., PMID:40359583
Targeting IL-6 in antibody-mediated kidney transplant rejection., PMID:40357502
Dynamics of Modified Cardiovascular Risk Factors in Patients with Rheumatoid Arthritis on the Background of 5-Year Therapy with an Interleukin 6 Receptor Inhibitor., PMID:40353962
High local type-2 inflammation is linked to response in severe asthma treated with anti-Interleukin-5 receptor., PMID:40345261
Interleukin-6 in neuroimmunological disorders: Pathophysiology and therapeutic advances with satralizumab., PMID:40324548
Neutrophil Z Is a Novel Marker to Differentiate Disease Flares From Bacterial Infections in Febrile SLE Patients., PMID:40302194
Advances in the treatment of neuromyelitis optic spectrum disorder., PMID:40291752
Reading of human acute immune dynamics in omicron SARS-CoV-2 breakthrough infection., PMID:40231451
Effectiveness of satralizumab in a real-world clinical setting in Japan: Interleukin-6 receptor inhibition in neuromyelitis optica spectrum disorder: A six-month interim analysis of a multicenter medical chart review., PMID:40203604
Nanobody Receptors Enable High-Sensitivity Monitoring of IL-6 Using Molecular Pendulum Bioanalysis., PMID:40173279
Update on tocilizumab in rheumatoid arthritis: a narrative review., PMID:40066438
Comparative effectiveness of subcutaneous sarilumab 200 mg biweekly, subcutaneous Tocilizumab 162 mg biweekly, and intravenous Tocilizumab 8 mg/kg every 4 weeks in patients with rheumatoid arthritis: a prospective cohort study., PMID:40055759
Pathogenesis and detection methods of anti-acetylcholine receptor antibodies in myasthenia gravis., PMID:40013423
Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review., PMID:40002820
Inhibition of inflammation by IL-6 blockade in xenotransplantation., PMID:39999679
Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice., PMID:39867844
Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer., PMID:39863722
Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection., PMID:39835136
IL-6 Signalling to Responding T Cells Is Key to Calcitonin Gene-Related Peptide-Exposed Endothelial Cell Enhancement of Th17 Immunity During Langerhans Cell Antigen Presentation., PMID:39829087
An engineered palivizumab IgG2 subclass for synthetic gp130 and fas-mediated signaling., PMID:39828098
Lipoprotein(a) and Atrial Fibrillation: Mechanistic Insights and Therapeutic Approaches., PMID:39781530
Anti-IL-6R Ab tocilizumab to treat paraneoplastic inflammatory syndrome of solid cancers., PMID:39754984
Successful Remission of Refractory Rheumatoid Pleural Effusion and Arthritis Using Sarilumab: A Case Report., PMID:39744302
Tocilizumab does not ameliorate inflammation-induced left ventricular dysfunction in a collagen-induced arthritis rat model., PMID:39734025
Targeting inerleukin-6 for renoprotection., PMID:39723211
Associations of genetic polymorphisms with clinical response to tocilizumab in Chinese rheumatoid arthritis patients., PMID:39718059
The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling., PMID:39653766
Targeting interleukin-6 pathways in giant cell arteritis management: A narrative review of evidence., PMID:39644981
Interleukin-6: Cardiovascular Aspects of Long-Term Cytokine Suppression in Patients with Rheumatoid Arthritis., PMID:39596487
Splenic γδ T cells mediate antidepressant and prophylactic actions of arketamine in lipopolysaccharide-induced depression in mice., PMID:39549733
Interleukin-6 receptor antibodies (tocilizumab) in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (DOBERMANN-T): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial., PMID:39501388
IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells., PMID:39496822
Interleukin-11 receptor is an alternative α-receptor for interleukin-6 and the chimeric cytokine IC7., PMID:39473075
Siltuximab for chimeric antigen receptor T-cell therapy-related CRS and ICANS: a multicenter retrospective analysis., PMID:39437770
Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19., PMID:39415081
Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Induces Hepatic Iron Overload in a Susceptible Patient., PMID:39401912
Pharmacological inhibition reveals participation of the endocytic compartment in positive feedback IL-6 secretion in human skeletal myotubes., PMID:39395584
Microenvironment-Activatable Probe for Precise NIR-II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis., PMID:39370578
Circulating Proteins Associated with Anti-IL6 Receptor Therapeutic Resistance in the Sera of Patients with Severe COVID-19., PMID:39352225
Tocilizumab in combination with standard of care in patients with severe COVID-19 pneumonia: Efficacy and safety from a phase 3 clinical trial in Japan., PMID:39326494
Cold abscess and high IgE beyond Job's syndrome: Four cases of IL-6R deficiency., PMID:39277818
Bi-allelic NRXN1α deletion in microglia derived from iPSC of an autistic patient increases interleukin-6 production and impairs supporting function on neuronal networking., PMID:39243986
Circular RNA Profile in Atherosclerotic Disease: Regulation during ST-Elevated Myocardial Infarction., PMID:39201700
Genetic, Clinical, Epidemiological, and Immunological Profiling of IgG Response Duration after SARS-CoV-2 Infection., PMID:39201427
Unexpected Expression and Function of FcεRI in Immortalized Breast Cancer Cells: A Cautionary Null Study., PMID:39195287
In vitro neutralization of IL-6 receptor exacerbates damage to intestinal epithelial cells during Mycobacterium avium paratuberculosis infection., PMID:39170608
Antagonist anti-LIF antibody derived from naive human scFv phage library inhibited tumor growth in mice., PMID:39169307
Selective inhibition of interleukin 6 receptor decreased inflammatory cytokines and increased proteases in an experimental model of critical calvarial defect., PMID:39166608
IL-6 Blockade in Cytokine Storm Syndromes., PMID:39117839
For research use only. Not for human or drug use.
