Catalog No.
FHD38910
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
TNF-R2, TNFR-II, p80 TNF-alpha receptor, Etanercept, TNFBR, TBP-2, TBPII, Tumor necrosis factor receptor superfamily member 1B, CD120b, p75, TNFRSF1B, Tumor necrosis factor receptor 2, TNF-RII, TNFR2, Tumor necrosis factor receptor type II
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P20333
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
E4#
[Protective аction of ginseng root extract on myofibril apoptosis and immune response in rats after exhausting physical exercise. Part II. Effect of ginseng root extract on immunity and regulation of energy metabolism]., PMID:40418135
Association of the TNFRSF1B-rs1061622 variant with nonresponse to infliximab in ulcerative colitis., PMID:40414945
TNFR2/CCR8 bispecific antibody enhances antitumor activity through depleting Ti-Tregs and boosting effector CD8+ T cell function., PMID:40293187
Neutrophil single-cell analysis identifies a type II interferon-related subset for predicting relapse of autoimmune small vessel vasculitis., PMID:40274824
TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions., PMID:40139648
To explore the influencing factors of clinical failure of anti-tumor necrosis factor-α (TNF-α) therapy in sepsis., PMID:40068733
Effect of Anti-TNF Monoclonal Antibody on Enteric Neurons and Enteric Glial Cells in Experimental Colitis., PMID:39946069
[Exploration of CCL11 and sTNFR2 as potential biomarkers for the efficacy of lymphocyte immunotherapy in women with unexplained recurrent spontaneous abortion]., PMID:39863550
In situ blockade of TNF-TNFR2 axis via oncolytic adenovirus improves antitumor efficacy in solid tumors., PMID:39690741
TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion., PMID:39562007
Ovalbumin-induced food allergy suppression via regulatory T cell expansion mediated by a TNFR2 agonist in mice., PMID:39489111
TNF receptors: Structure-function relationships and therapeutic targeting strategies., PMID:39442606
The combination of a PTP1B inhibitor, TNFR2 blocker, and PD‑1 antibody suppresses the progression of non‑small cell lung cancer tumors by enhancing immunocompetence., PMID:39301655
A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation., PMID:39289477
Targeting TNFR2 for cancer immunotherapy: recent advances and future directions., PMID:39223671
Interferon-gamma signaling drives epithelial TNF-alpha receptor-2 expression during colonic tissue repair., PMID:39139033
Case report: Recombinant human type II tumour necrosis factor receptor-antibody fusion protein induced occult hepatitis B virus reactivation leading to liver failure., PMID:38760056
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis., PMID:38689292
Cytokine Signaling in Pediatric Kidney Tumor Cell Lines WT-CLS1, WT-3ab and G-401., PMID:38396958
Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation., PMID:38341270
An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering., PMID:38262291
Generic design principles for antibody-based tumour necrosis factor (TNF) receptor 2 (TNFR2) agonists with FcγR-independent agonism., PMID:38169605
A novel single domain bispecific antibody targeting VEGF and TNF-α ameliorates rheumatoid arthritis., PMID:37992444
Low-dose TNF-α promotes angiogenesis of oral squamous cell carcinoma cells via TNFR2/Akt/mTOR axis., PMID:37964399
Determination of soluble tumor necrosis factor receptor II and secretory immunoglobulin A in saliva of patients with dementia., PMID:37838644
Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection., PMID:37758868
MAIT cells confer resistance to Lenvatinib plus anti-PD1 antibodies in hepatocellular carcinoma through TNF-TNFRSF1B pathway., PMID:37717672
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFα/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells., PMID:37716622
Therapeutic potential of infliximab for pruritus in mice model of cholestasis induced by bile duct ligation: Possible involvement of IL-31., PMID:37597403
Study of tumor necrosis factor receptor in the inflammatory bowel disease., PMID:37274062
Double-negative T cells regulate the progression of liver fibrosis through Th9 cells differentiation., PMID:37249033
Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis., PMID:37122019
Strategies for optimizing CITE-seq for human islets and other tissues., PMID:36936943
Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma., PMID:36882225
Identification and classification of distinct surface markers of T regulatory cells., PMID:36741366
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells., PMID:36369606
Distepharinamide, a novel dimeric proaporphine alkaloid from Diploclisia glaucescens, inhibits the differentiation and proliferative expansion of CD4+Foxp3+ regulatory T cells., PMID:36202057
Role of endothelial dysfunction in the severity of COVID‑19 infection (Review)., PMID:36196882
Recombinant Spider Silk Bioinks for Continuous Protein Release by Encapsulated Producer Cells., PMID:36067476
Integrin β1, PDGFRβ, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in rats., PMID:35986079
CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration., PMID:35981418
High-throughput analysis of amniotic fluid proteins associated with histological chorioamnionitis in preterm premature rupture of membranes using an antibody-based microarray., PMID:35792516
A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity., PMID:35769484
The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy., PMID:35741080
Comparative Pharmacokinetics, Safety, and Immunogenicity Study of the Prefilled Syringe and Lyophilized Formulation of a Recombinant Human Tumor Necrosis Factor-α Receptor II:lgG Fc Fusion Protein in Healthy Chinese Male Subjects., PMID:35419986
TNFR2 blockade of regulatory T cells unleashes an antitumor immune response after hematopoietic stem-cell transplantation., PMID:35387779
Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors., PMID:35260434
Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity., PMID:35251028
Splenic Architecture and Function Requires Tight Control of Transmembrane TNF Expression., PMID:35216345
TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells., PMID:35149531
For research use only. Not for human or drug use.
