Catalog No.
FHD34010
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
TNFR-I, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, TBPI, p60, CD120a, TNFRSF1A, Tumor necrosis factor receptor type I, p55, TNF-RI, TNFAR, TNFR1, TNF-R1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P19438
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
H398
TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair potential in degenerative conditions., PMID:40139648
To explore the influencing factors of clinical failure of anti-tumor necrosis factor-α (TNF-α) therapy in sepsis., PMID:40068733
RANKL-derived peptide MHP1-AcN attenuates ovariectomy-induced osteoporosis by targeting RANK and TNFR1 in mice., PMID:40032017
In situ blockade of TNF-TNFR2 axis via oncolytic adenovirus improves antitumor efficacy in solid tumors., PMID:39690741
TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases., PMID:39562788
NPS-1034 Exerts Therapeutic Efficacy in Renal Cell Carcinoma Through Multiple Targets of MET, AXL, and TNFRSF1A Signaling in a Metastatic Model., PMID:39451232
TNF receptors: Structure-function relationships and therapeutic targeting strategies., PMID:39442606
TNFR1 signaling promotes pancreatic tumor growth by limiting dendritic cell number and function., PMID:39178856
TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses., PMID:39126792
Higher levels of markers for early atherosclerosis in anti-citrullinated protein antibodies positive individuals at risk for RA, a cross sectional study., PMID:39012360
Tumor necrosis factor α receptor 1A transduces the inhibitory effect on axon regeneration triggered by IgG anti-ganglioside GD1a antibodies., PMID:38897255
Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement., PMID:38562920
The First Case of a Korean Patient with a Mutation-Confirmed Tumor Necrosis Factor Receptor-Associated Periodic Syndrome., PMID:38515362
Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis induces the death of mouse lymphocytes in a mechanism dependent on Toll-like receptor 4 and tumor necrosis factor., PMID:38512915
TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease., PMID:38404573
Efficacy of canakinumab for mosaic tumor necrosis factor receptor associated periodic syndrome., PMID:38307733
TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria., PMID:38115011
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer., PMID:38037106
[Clinical analysis of 10 cases of multi-center tumor necrosis factor receptor-associated periodic syndrome]., PMID:38018047
Therapeutic potential of infliximab for pruritus in mice model of cholestasis induced by bile duct ligation: Possible involvement of IL-31., PMID:37597403
Study of tumor necrosis factor receptor in the inflammatory bowel disease., PMID:37274062
Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis., PMID:37122019
TNF-R1 Cellular Nanovesicles Loaded on the Thermosensitive F-127 Hydrogel Enhance the Repair of Scalded Skin., PMID:37043416
Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression., PMID:37021574
Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma., PMID:36882225
Synovial macrophages of rheumatoid arthritic mice protectively responded by altered M1/M2 differentiation after antibody blocking of TNFR1 and IL-1R., PMID:36621328
CD20/TNFR1 dual-targeting antibody enhances lysosome rupture-mediated cell death in B cell lymphoma., PMID:36534148
The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus., PMID:36311714
The utility of inflammatory and endothelial factors in the prognosis of severe dengue., PMID:36257203
Tumour necrosis factor plays a deleterious role in the pathogenesis of chikungunya virus infection., PMID:36164989
Tumor Necrosis Factor-α-Induced C-C Motif Chemokine Ligand 20 Expression through TNF Receptor 1-Dependent Activation of EGFR/p38 MAPK and JNK1/2/FoxO1 or the NF-κB Pathway in Human Cardiac Fibroblasts., PMID:36012347
Integrin β1, PDGFRβ, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in rats., PMID:35986079
Double-negative T cells mediate M1 polarization of microglial cells via TNF-α-NLRP3 to aggravate neuroinflammation and cognitive impairment in Alzheimer's disease mice., PMID:35866513
STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20., PMID:35841281
Phenotype and cytokine profile in a TRAPS Syndrome family with TNFRSF1A p.(Thr79Met): Association with sacro-iliitis., PMID:35577052
Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis., PMID:35488351
Splenic Architecture and Function Requires Tight Control of Transmembrane TNF Expression., PMID:35216345
TNF-TNFR1 Signaling Enhances the Protection Against Neospora caninum Infection., PMID:35071042
Selective Targeting of Tumour Necrosis Factor Receptor 1 Induces Stable Protection from Crohn's-Like Ileitis in TNFΔARE Mice., PMID:34893805
Microglia-derived TNF-α mediates Müller cell activation by activating the TNFR1-NF-κB pathway., PMID:34801535
Effects of Antibodies to Glutamate on Cerebral Expression of the Tnfrsf1A Gene under Conditions of Spatial Amnesia Induced by Proinflammatory Protein S100A9 Fibrils in Aging Mice., PMID:34796426
Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice., PMID:34664730
Anti-inflammatory treatment in MPN: targeting TNFR1 and TNFR2 in JAK2-V617F-induced disease., PMID:34592754
An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease., PMID:34576184
Tumor necrosis factor receptor-1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as a TNFα decoy., PMID:34559433
Huangqi Guizhi Wuwu Decoction attenuates Podocyte cytoskeletal protein damage in IgA nephropathy rats by regulating AT1R/Nephrin/c-Abl pathway., PMID:34339916
The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation., PMID:34305946
A Straightforward Method for 3D Visualization of B Cell Clusters and High Endothelial Venules in Lymph Nodes Highlights Differential Roles of TNFRI and -II., PMID:34234786
Etanercept Protected Against Cigarette Smoke Extract-Induced Inflammation and Apoptosis of Human Pulmonary Artery Endothelial Cells via Regulating TNFR1., PMID:34007171
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation., PMID:33835418
For research use only. Not for human or drug use.
