Catalog No.
YVV11503
Expression system
E. coli
Species
Hepatitis B virus
Protein length
Met1-Val149
Predicted molecular weight
29.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
AJR19223.1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Capsid protein, C, Core antigen, Core protein, HBcAg, p21.5
Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors. PMID: 35921789
4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators. PMID: 34979256
Diazepinone HBV capsid assembly modulators. PMID: 35644301
Major findings and recent advances in virus-like particle (VLP)-based vaccines. PMID: 28887001
Endoplasmic reticulum stress promotes HBV production by enhancing use of the autophagosome/multivesicular body axis. PMID: 34580902
Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly. PMID: 24462683
Oxadiazepinone HBV capsid assembly modulators. PMID: 34492302
An in silico study to unveil potential drugs and vaccine chimera for HBV capsid assembly protein: combined molecular docking and dynamics simulation approach. PMID: 35112241
Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation. PMID: 36226986
Capsid Assembly Modulators as Antiviral Agents against HBV: Molecular Mechanisms and Clinical Perspectives. PMID: 35268440
Core protein: A pleiotropic keystone in the HBV lifecycle. PMID: 26129969
Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778. PMID: 36144715
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B. PMID: 32818519
HBV Core Protein Is in Flux between Cytoplasmic, Nuclear, and Nucleolar Compartments. PMID: 33563815
Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers. PMID: 21126747
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors. PMID: 32712535
Di-Fluoro Azepane HBV Capsid Assembly Modulators. PMID: 37247697
Reactive oxygen species promote heat shock protein 90-mediated HBV capsid assembly. PMID: 25576869
Biogenesis and molecular characteristics of serum hepatitis B virus RNA. PMID: 33079954
Identification of a new class of HBV capsid assembly modulator. PMID: 33610748
Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein. PMID: 37243280
Recent advances in the development of HBV capsid assembly modulators. PMID: 30952041
Pyrimidotriazine derivatives as selective inhibitors of HBV capsid assembly. PMID: 31376401
Dynamics of Hepatitis B Virus Capsid Protein Dimer Regulate Assembly through an Allosteric Network. PMID: 32662972
Role of core protein mutations in the development of occult HBV infection. PMID: 33453326
Heat shock protein 70 and heat shock protein 90 synergistically increase hepatitis B viral capsid assembly. PMID: 30115382
The Origin of Capsid-Derived Immune Complexes and Their Impact on HBV-Induced Liver Diseases. PMID: 36560770
Generation of an HBV core phenotyping assay for evaluating HBV capsid compounds. PMID: 33657432
Modulators of HBV capsid assembly as an approach to treating hepatitis B virus infection. PMID: 27636324
RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation. PMID: 34287051
Towards HBV curative therapies. PMID: 29427479
Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro. PMID: 32417895
Carboxy-terminal truncations of the HBV core protein affect capsid formation and the apparent size of encapsidated HBV RNA. PMID: 7684872
Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket. PMID: 36042894
Discovery of novel HBV capsid assembly modulators by structure-based virtual screening and bioassays. PMID: 33721800
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein. PMID: 34826506
Hepatitis B Virus Core Protein Domains Essential for Viral Capsid Assembly in a Cellular Context. PMID: 32371046
The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals. PMID: 29183719
Viral structural proteins as targets for antivirals. PMID: 32777753
For research use only. Not for human or drug use.
