Catalog No.
EHJ93301
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
[Phe 29-Pro 243] & [Met 1-Lys 229]
Predicted molecular weight
52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NEV9 & Q14213
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL27, p28, Interleukin-27 subunit alpha, IL-27 subunit alpha, IL27A, IL27, IL-27-A, Interleukin-30, IL30, IL27-A, IL-27B, Interleukin-27 subunit beta, EBI3, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, IL27B, IL-27 subunit beta
Serum Levels of IL-21 and IL-27 Do not Reflect differential Avidity of Anti-SARS-CoV-2 IgG Antibodies in Symptomatic and Asymptomatic COVID-19 Patients., PMID:40471646
Impact of tail unsaturation in ionizable lipids on mRNA delivery efficiency and immunogenicity of lipid nanoparticles., PMID:40460931
Integrative transcriptomic and single-cell analysis reveals IL27RA as a key immune regulator and therapeutic indicator in breast cancer., PMID:40450602
Research status and future perspectives of IL‑27 in the treatment of stroke (Review)., PMID:40444496
Integrating Transcriptomic and Proteomic Data: IL-27B as a Key Protein in the Development of Septic Cardiomyopathy-A Retrospective Study., PMID:40396598
A combinatorial siRNA and mRNA approach for obesity treatment using targeting lipid nanoparticles., PMID:40383157
Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms., PMID:40366856
Novel oncolytic vaccinia virus armed with interleukin-27 is a potential therapeutic agent for the treatment of murine pancreatic cancer., PMID:40350204
Neuroinflammation and Amyotrophic Lateral Sclerosis: Recent Advances in Anti-Inflammatory Cytokines as Therapeutic Strategies., PMID:40332510
IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination., PMID:40328205
Serum Concentrations of IL-18, IL-21, IL-22, IL-23, IL-27, and IL-31 in Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Their Correlation With Disease Severity., PMID:40322299
Inhibition of hepatitis C virus replication in HepG2 cells via modulation of the Raf-1 and interferon-alpha signaling pathways by thymoquinone., PMID:40317342
The overlooked trio: sleep duration, sampling time and physical exercise alter levels of olink-assessed blood biomarkers of cardiovascular risk., PMID:40301994
ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27., PMID:40281007
Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance., PMID:40276760
Accelerating and protective effects toward cancer growth in cGAS and FcgRIIb deficient mice, respectively, an impact of macrophage polarization., PMID:40272597
IL-27 accelerates diabetic wound healing by modulating macrophage polarization., PMID:40199138
Factors influencing the development of osteoporosis in elderly patients with rheumatoid arthritis., PMID:40190502
Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity., PMID:40187354
Umbilical cord blood level of interleukins used as a predictor of early-onset neonatal sepsis: a comprehensive review., PMID:40171168
Modulation of Macrophages TLR4-Mediated Transcriptional Response by Lacticaseibacillus rhamnosus CRL1505 and Lactiplantibacillus plantarum CRL1506., PMID:40141330
Tigecycline modulates LPS-induced inflammatory response in sepsis via NF-κB signalling pathways: Experimental insights into immune regulation., PMID:40139445
Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the antiviral effect via different mechanisms in the individual cell-dependent manner., PMID:40129989
IL-6/IL-12 superfamily of cytokines and regulatory lymphocytes play critical roles in the etiology and suppression of CNS autoimmune diseases., PMID:40114923
IL-27 alleviates high-fat diet-induced obesity and metabolic disorders by inhibiting adipogenesis via activating HDAC6., PMID:40108289
Association between autoimmune disease and neurodevelopmental disorder: a Mendelian randomization analysis., PMID:40082977
Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents., PMID:40064430
Integrated Transcriptome Analysis of lncRNA, miRNA, and mRNA Reveals key Regulatory Modules for Polycystic Ovary Syndrome., PMID:40061822
Impact of single nucleotide polymorphism of IL-27P28 rs153109 and IFITM3 rs12252 on susceptibility and severity of COVID-19 in Egyptian patients: a case control study., PMID:40057761
Interleukin-27 deletion has neuroprotective effects in the acute ischemic stage of cerebral infarction., PMID:40048763
IL-27 producers in a neonatal BCG vaccination model are a heterogenous population of myeloid cells that are diverse in phenotype and function., PMID:40048708
Interleukins-27 Aggravates Liver Injury by Impairing the Antimicrobial Response of Macrophages via the Promotion of Mitochondrial Dysfunction in the Context of Sepsis., PMID:40046257
Cytokine atlas of the population-based cohort SHIP-TREND-0 - Associations with age, sex, and BMI., PMID:40020520
Dynamics of Serum Cytokines and Chemokines in Patients With Idiopathic Multicentric Castleman Disease: From a Phase Ib Investigator-Initiated Trial of Filgotinib., PMID:39958406
IL-27 regulates macrophage ferroptosis by inhibiting the Nrf2/HO1 signaling pathway in sepsis-induced ARDS., PMID:39945893
IL-27 aggravates acute hepatic injury by promoting macrophage M1 polarization to induce Caspase-11 mediated Pyroptosis in vitro and in vivo., PMID:39913960
IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control., PMID:39910298
Higher T-bet and IFN-γ expression in advanced chagasic megaesophagus indicates Th1 response in the chronic phase., PMID:39907396
Revisiting the role of IL-27 in obesity-related metabolic diseases: safeguard or perturbation?, PMID:39906735
Epstein-Barr Virus-Induced 3 Attributes to TLR7-Mediated Splenomegaly., PMID:39876525
Prognostic significance of cytokine dysregulation in critically ill COVID-19 patients., PMID:39874939
The causal association between cardiovascular proteins and diabetic nephropathy: a Mendelian randomization study., PMID:39864027
Exploring the Involvement of New Members of the Interleukin Family in Cardiovascular Disease., PMID:39844544
Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatment., PMID:39837012
Sinensetin attenuates LPS-induced acute pulmonary inflammation in mice and RAW264.7 cells by modulating NF-κB p65-mediated immune resistance and STAT3-mediated tissue resilience., PMID:39827664
Novel Neurocognitive Testing Tool for Early Neurotoxicity Detection Following Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor (CAR) T-cell Therapy: A Pilot Study., PMID:39814673
Evaluation of a novel serum marker, interleukin 27, in comparison to procalcitonin and C-reactive protein in the diagnosis of early-onset neonatal sepsis in a tertiary care center in north India., PMID:39811034
The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis., PMID:39810405
Harnessing IL-27: challenges and potential in cancer immunotherapy., PMID:39797931
Long-term mitochondrial and metabolic impairment in lymphocytes of subjects who recovered after severe COVID-19., PMID:39792183
For research use only. Not for human or drug use.
