Anti-RPS6KA1 Polyclonal Antibody

Catalog No.

PHH09501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human RPS6KA1 (Phe62-Tyr321).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

p90-RSK 1,Ribosomal S6 kinase 1,RSK1,p90RSK1,RPS6KA1,MAPKAP kinase 1a,MAPK-activated protein kinase 1a,RSK-1,MAPKAPK1A,MAP kinase-activated protein kinase 1a,MAPKAPK-1a,S6K-alpha-1,90 kDa ribosomal protein S6 kinase 1,Ribosomal protein S6 kinase alpha-1,p90S6K

Purification

Purified by antigen affinity column.

Accession

Q15418

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity., PMID:29615689

Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway., PMID:29449532

Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells., PMID:29048432

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells., PMID:27300509

Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice., PMID:26135885

Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide., PMID:24058693

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism., PMID:24036112

Self-antigen recognition by follicular lymphoma B-cell receptors., PMID:23024238

MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition., PMID:22249268

YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention., PMID:21576761

Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression., PMID:21340650

Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes., PMID:20203102

S6K1 deficiency protects against apoptosis in hepatocytes., PMID:19437488

ERK and p38 pathways regulate amino acid signalling., PMID:18809440

Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation., PMID:16751795

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3., PMID:15461589

Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors., PMID:15112576

Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland., PMID:12668683

Bacterial heat shock protein-60 increases epithelial cell proliferation through the ERK1/2 MAP kinases., PMID:11339820

Nuclear localization and regulation of erk- and rsk-encoded protein kinases., PMID:1545823

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity., PMID:2052581

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