Catalog No.
YHE99901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu142
Predicted molecular weight
19.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P53680
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Adaptor-related protein complex 2 subunit sigma, Clathrin assembly protein 2 sigma small chain, HA2 17 kDa subunit, AP2S1, Clathrin coat-associated protein AP17, Clathrin coat assembly protein AP17, AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, CLAPS2, AP17, Sigma2-adaptin, Plasma membrane adaptor AP-2 17 kDa protein
Case report: Clinical and genetic characteristics of heterozygous CaSR variants in three Chinese females with familial hypocalciuric hypercalcemia type 1: a report of three cases., PMID:40417236
The HAVCR1-centric host factor network drives Zika virus vertical transmission., PMID:40156834
Successful Treatment With Evocalcet Against Familial Hypocalciuric Hypercalcemia Type 3 (FHH3) Identified by AP2S1 Gene Mutation (p.Arg15Leu)., PMID:39949382
GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR., PMID:39893205
[Familial Hypocalciuric Hypercalcemia Type 1 Likely Secondary to a New Inactivating Mutation of CASR]., PMID:39243411
Familial hypocalciuric hypercalcemia in an infant: diagnosis and management quandaries., PMID:39163488
Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats., PMID:38990251
Aldehyde Dehydrogenese-1 High Cancer Stem-like Cells/Cancer-initiating Cells Escape from Cytotoxic T Lymphocytes due to Lower Expression of Human Leukocyte Antigen Class 1., PMID:38677758
Genetic profile of a large Spanish cohort with hypercalcemia., PMID:38586466
Host proteins interact with viral elements and affect the life cycle of highly pathogenic avian influenza A virus H7N9., PMID:38560106
The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows., PMID:38550987
Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia., PMID:38487341
GCM2 p.Tyr394Ser variant in Ashkenazi Israeli patients with suspected familial isolated hyperparathyroidism., PMID:38130397
Proteomic analysis of boar sperm with differential ability of liquid preservation at 17 °C., PMID:38029685
Genetic and clinical screening for hereditary primary hyperparathyroidism in a large Chinese cohort: a single-center study., PMID:37449924
Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity., PMID:36972301
AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice., PMID:36412210
A contemporary clinical approach to genetic testing for heritable hyperparathyroidism syndromes., PMID:34773560
Proteomic Insights Into Susceptibility and Resistance to Chronic-Stress-Induced Depression or Anxiety in the Rat Striatum., PMID:34676246
Characterization of Exosome-Related Gene Risk Model to Evaluate the Tumor Immune Microenvironment and Predict Prognosis in Triple-Negative Breast Cancer., PMID:34659224
Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2., PMID:33729479
Misleading localization by 18F-fluorocholine PET/CT in familial hypocalciuric hypercalcemia type-3: a case report., PMID:33499837
[A series of clinical cases of familial hypocalciuric hypercalcemia syndrome]., PMID:33369373
Familial hypocalciuric hypercalcaemia type 3: AP2S1 missense mutation., PMID:33168530
A Novel Variant in the Calcium-Sensing Receptor Associated with Familial Hypocalciuric Hypercalcemia and Low-to-Normal PTH., PMID:33062349
Autoimmune Hypercalcemia Due to Autoantibodies Against the Calcium-sensing Receptor., PMID:32311038
Severe Primary Hyperparathyroidism Caused by Parathyroid Carcinoma in a 13-Year-Old Child; Novel Findings From HRpQCT., PMID:32161840
Clinical and Biochemical Features in a Case of Familial Hypocalciuric Hypercalcemia Type 3 with AP2S1 Gene Mutation in Codon Arg15His., PMID:32047691
A NOVEL MUTATION IN CALCIUM-SENSING RECEPTOR PRESENTING AS FAMILIAL HYPOCALCIURIC HYPERCALCEMIA IN A YOUNG MAN., PMID:31967040
Neonatal Severe Hyperparathyroidism: Novel Insights From Calcium, PTH, and the CASR Gene., PMID:31778168
A Hong Kong Chinese kindred with familial hypocalciuric hypercalcaemia caused by AP2S1 mutation., PMID:31723423
Expanding the spectrum of genetic variants in the calcium-sensing receptor (CASR) gene in hypercalcemic individuals., PMID:31433865
Cinacalcet sustainedly prevents pancreatitis in a child with a compound heterozygous SPINK1/AP2S1 mutation., PMID:31391146
Evolution of Our Understanding of the Hyperparathyroid Syndromes: A Historical Perspective., PMID:30536424
A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making., PMID:29681477
High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays., PMID:29560723
N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice., PMID:29479578
Large-scale exome datasets reveal a new class of adaptor-related protein complex 2 sigma subunit (AP2σ) mutations, located at the interface with the AP2 alpha subunit, that impair calcium-sensing receptor signalling., PMID:29325022
Calcimimetic Use in Familial Hypocalciuric Hypercalcemia-A Perspective in Endocrinology., PMID:28945857
Stepwise CaSR, AP2S1, and GNA11 sequencing in patients with suspected familial hypocalciuric hypercalcemia., PMID:28176280
Diseases associated with calcium-sensing receptor., PMID:28122587
AP2S1 and GNA11 mutations - not a common cause of familial hypocalciuric hypercalcemia., PMID:27913609
Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis., PMID:27647839
[A genomic study of adult-onset idiopathic hypoparathyroidism in Chinese by targeted next-generation sequencing]., PMID:27480553
Cinacalcet for Symptomatic Hypercalcemia Caused by AP2S1 Mutations., PMID:27050234
Familial Hypocalciuric Hypercalcemia Types 1 and 3 and Primary Hyperparathyroidism: Similarities and Differences., PMID:26963950
GENETICS IN ENDOCRINOLOGY: Gain and loss of function mutations of the calcium-sensing receptor and associated proteins: current treatment concepts., PMID:26646938
Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype-phenotype correlations, codon bias and dominant-negative effects., PMID:26082470
Cinacalcet Treatment in an Adolescent With Concurrent 22q11.2 Deletion Syndrome and Familial Hypocalciuric Hypercalcemia Type 3 Caused by AP2S1 Mutation., PMID:25993639
Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population., PMID:25104082
For research use only. Not for human or drug use.
