Catalog No.
YHE60901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys298-Leu467
Predicted molecular weight
21.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P48736
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PtdIns-3-kinase subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, PtdIns-3-kinase subunit p110-gamma, PI3Kgamma, p120-PI3K, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PI3-kinase subunit gamma, PI3K-gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p110gamma, PIK3CG
Assessing the toxicological effects and mechanism of plasticizer exposure on inflammatory bowel disease based on network toxicology and molecular docking., PMID:40354873
A Multi-Level Study on the Anti-Lung Cancer Mechanism of Peiminine, a Key Component of Fritillaria ussuriensis Maxim.: Integrating Quality Analysis, Network Pharmacology, Bioinformatics Analysis, and Experimental Validation., PMID:40331978
The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway., PMID:40255567
Network-based pharmacological and experimentally validated study on the therapeutic effects and mechanisms of Polygonatum Rhizoma Ginseng Formula in immunocompromised mice., PMID:40250634
Isorhamnetin ameliorates hyperuricemia by regulating uric acid metabolism and alleviates renal inflammation through the PI3K/AKT/NF-κB signaling pathway., PMID:40111208
Comprehensive exploration of programmed cell death landscape in lung adenocarcinoma combining multi-omic analysis and experimental verification., PMID:39948103
Targeting PI3Kγ in cancer., PMID:39947962
Plinabulin exerts an anti-proliferative effect via the PI3K/AKT/mTOR signaling pathways in glioblastoma., PMID:39877641
Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control., PMID:39788719
Unveiling the substantial role of rutin in the management of drug-induced nephropathy using network pharmacology and molecular docking., PMID:39733639
Role of PI3Kγ in the polarization, migration, and phagocytosis of microglia., PMID:39675432
Current developments in PI3K-based anticancer agents: Designing strategies, biological activity, selectivity, structure-activity correlation, and docking insight., PMID:39662340
Protective effects of PIK3CG knockdown against OGD/R-induced neuronal damage via inhibition of autophagy through the AMPK/mTOR pathway., PMID:39603405
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells., PMID:39565875
Targeting PI3Kγ Pathway for Treating Dengue virus Infection., PMID:39490942
Effective Components and Molecular Mechanism of Biejiaruangan Capsule Against Liver Fibrosis: High-resolution Mass Spectrometry, Network Pharmacological Analysis and Experimental Verification., PMID:39411945
MELATONIN ENHANCES TEMOZOLOMIDE-INDUCED APOPTOSIS IN GLIOBLASTOMA AND NEUROBLASTOMA CELLS., PMID:39396175
A nonnatural peptide targeting the A-kinase anchoring function of PI3Kγ for therapeutic cAMP modulation in pulmonary cells., PMID:39393573
Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody-Activated, Inducible Cross-Presentation in Murine Type 2 DCs., PMID:39382167
Prediction of immunotherapy response using mutations to cancer protein assemblies., PMID:39303028
A common variant in PIK3CG gene associated with the prognosis of heart failure., PMID:39245801
Discovery of Pyrazolo[1,5-a]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors., PMID:39163191
Chemical analogue based drug design for cancer treatment targeting PI3K: integrating machine learning and molecular modeling., PMID:39154146
[Gene mutation characteristics of clinical stage ⅠA lung adenocarcinoma and their relations with patients' long-term prognosis]., PMID:39143798
Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline., PMID:39143319
The molecular and network mechanisms of antilipidemic potential effects of Ganfule capsules in nonalcoholic fatty liver disease., PMID:39113948
Targeting PI3K-gamma in myeloid driven tumour immune suppression: a systematic review and meta-analysis of the preclinical literature., PMID:39105848
Inhibiting PI3Kγ in acute myeloid leukemia., PMID:39048732
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia., PMID:39029455
PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm., PMID:39024551
Designing Small Molecule PI3Kγ Inhibitors: A Review of Structure-Based Methods and Computational Approaches., PMID:38988222
Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking., PMID:38983404
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells., PMID:38961274
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections., PMID:38959328
Suppression of Ventilation-Induced Diaphragm Fibrosis through the Phosphoinositide 3-Kinase-γ in a Murine Bleomycin-Induced Acute Lung Injury Model., PMID:38928077
Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168
Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule., PMID:38816660
Targetable leukaemia dependency on noncanonical PI3Kγ signalling., PMID:38720074
Overexpression of PIK3CG in Cancer Cells Promotes Lung Cancer Cell Migration and Metastasis Through Enhanced MMPs Expression and Neutrophil Recruitment and Activation., PMID:38602596
[Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]., PMID:38597437
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ., PMID:38565696
Integrated network toxicology, molecular docking, and in vivo experiments to elucidate molecular mechanism of aflatoxin B1 hepatotoxicity., PMID:38564860
Biomarkers and coptis chinensis activity for rituximab-resistant diffuse large B-cell lymphoma: Combination of bioinformatics analysis, network pharmacology and molecular docking., PMID:38517810
Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism., PMID:38428514
PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway., PMID:38271660
Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway., PMID:38256877
Upregulation of Anti-Angiogenic miR-106b-3p Correlates Negatively with IGF-1 and Vascular Health Parameters in a Model of Subclinical Cardiovascular Disease: Study with Metformin Therapy., PMID:38255276
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation., PMID:38241399
IRF5 governs macrophage adventitial infiltration to fuel abdominal aortic aneurysm formation., PMID:38175709
Therapeutic potential of anti-PIK3CG treatment for multiple myeloma via inhibiting c-Myc pathway., PMID:38163179
For research use only. Not for human or drug use.
