Catalog No.
YHE35301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met152-Val349
Predicted molecular weight
25.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42338
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p110beta, PI3Kbeta, PtdIns-3-kinase subunit p110-beta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PIK3CB, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, PtdIns-3-kinase subunit beta, PI3-kinase subunit beta, PIK3C1, PI3K-beta
Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology., PMID:40421220
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer., PMID:40413189
Transcriptome analysis reveals key genes and signalling pathways related to residual feed intake in meat-type ducks., PMID:40367888
Characterization of the Active Ingredients and Prediction of the Potential Anticolitis Mechanism of the Feng-Liao-Chang-Wei-Kang Capsule via Mass Spectrometry and Network Pharmacology., PMID:40365509
The Molecular Mechanisms of Bergapten Against Abdominal Aortic Aneurysm: Evidence From Network Pharmacology, Molecular Docking/Dynamics, and Experimental Validation., PMID:40159385
Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth., PMID:40106438
Tiliroside from Lagopsis supina Ameliorates Myocardial Ischemia Injury in Zebrafish by Activating the kdr-Mediated PI3K-Akt and MAPK Signaling Pathways., PMID:40076931
Multi-gene risk score for prediction of clinical outcomes in treatment-naïve metastatic castrate-resistant prostate cancer., PMID:40036789
C15orf39, a downstream effector of PI3K/AKT signaling, promotes gastric carcinogenesis and correlates with patient outcomes., PMID:40032127
Design, synthesis and molecular dynamics simulations of thiazole-based hydrazones targeting MDA-MB-231 breast cancer cells., PMID:40022851
Polygonum capitatum combined with ciprofloxacin ameliorated chronic bacterial prostatitis by inhibiting NF-κB/IL-6/JAK2/STAT3 pathway., PMID:40010554
Descriptive Comparative Transcriptomic Analysis of Genotype IV SHEV ORF3-Expressing HepG2 Cells., PMID:40005777
Study on the effect and mechanism of ZeXie decoction in treating MSU-induced acute gouty arthritis model through PI3K-AKT-mTOR signaling pathway., PMID:39952005
Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves' disease through integrated serum metabolomics and network pharmacology with molecular docking techniques., PMID:39950029
Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction., PMID:39842746
Amide Internucleoside Linkages Suppress the MicroRNA-like Off-Target Activity of Short Interfering RNA., PMID:39813044
Exploration of the Fasting Hypoglycemic Mechanism of Casein Hydrolysate Enriched with Glu/Gln and Glu/Gln-Containing Peptides in db/db Diabetic-like Mice Using Multiomics Analysis., PMID:39788553
Identifying preeclampsia-associated key module and hub genes via weighted gene co-expression network analysis., PMID:39779839
Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes., PMID:39722169
An 8-Week Very Low-Calorie Ketogenic Diet (VLCKD) Alters the Landscape of Obese-Derived Small Extracellular Vesicles (sEVs), Redefining Hepatic Cell Phenotypes., PMID:39683581
Current developments in PI3K-based anticancer agents: Designing strategies, biological activity, selectivity, structure-activity correlation, and docking insight., PMID:39662340
Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma., PMID:39636745
Association between insulin-associated gene polymorphisms and new-onset diabetes mellitus in statin-treated patients., PMID:39614667
USP8-mediated PTK7 promotes PIK3CB-related pathway to accelerate the malignant progression of non-small cell lung cancer., PMID:39552193
Network pharmacology and in vitro experiments reveal the potential therapeutic effects of Scrophularia ningpoensis Hemsl in the treatment of ameloblastoma., PMID:39551179
Role of Circular RNA MMP9 in Glioblastoma Progression: From Interaction With hnRNPC and hnRNPA1 to Affecting the Expression of BIRC5 by Sequestering miR-149., PMID:39401767
Integrating network pharmacology, molecular docking and non-targeted serum metabolomics to illustrate pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction in treating hyperthyroidism., PMID:39387049
Whole genome re-sequencing reveals high altitude adaptation signatures and admixture in Ladakhi cattle., PMID:39306203
Distinct FLT3 Pathways Gene Expression Profiles in Pediatric De Novo Acute Lymphoblastic and Myeloid Leukemia with FLT3 Mutations: Implications for Targeted Therapy., PMID:39273530
PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells., PMID:39190024
Exploring the Effect of Active Components in Oil Tree Peony Seed Meal on Swine Disease Resistance and its Potential Mechanisms Based on Network Pharmacology and Molecular Docking., PMID:39172434
Investigation into the potential mechanism and therapeutic targets of Cangzhu Erchen decoction for the treatment of chronic obstructive pulmonary disease based on bioinformatics and network pharmacology., PMID:39151493
Herb-CMap: a multimodal fusion framework for deciphering the mechanisms of action in traditional Chinese medicine using Suhuang antitussive capsule as a case study., PMID:39073832
Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria., PMID:39060313
Case report: Metastatic refractory undifferentiated small round-cell sarcoma successfully treated with surufatinib and camrelizumab., PMID:39055564
PIK3/Akt/mTOR pathway alterations in metastatic castration-sensitive prostate cancer., PMID:39021052
KLHL21 suppresses gastric tumourigenesis via maintaining STAT3 signalling equilibrium in stomach homoeostasis., PMID:38969490
Whole-exome Sequencing of Atypical Parathyroid Tumors Detects Novel and Common Genes Linked to Parathyroid Tumorigenesis., PMID:38940486
Mechanism of Dahuang Mudan Decotion in the treatment of colorectal cancer based on network pharmacology and experimental validation., PMID:38882337
Integrated mRNA-miRNA transcriptome profiling of blood immune responses potentially related to pulmonary fibrosis in forest musk deer., PMID:38873601
SMARCC2 silencing suppresses oncogenic activation through modulation of chromatin accessibility in breast cancer., PMID:38852505
Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases., PMID:38713746
Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA., PMID:38573494
Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12., PMID:38561055
Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction., PMID:38545623
Efficacy and potential mechanism of atherosclerosis prevention by the active components of leech based on network pharmacology combined with animal experiments., PMID:38515732
A Mass Spectrometry-Based Proteome Study of Twin Pairs Discordant for Incident Acute Myocardial Infarction within Three Years after Blood Sampling Suggests Novel Biomarkers., PMID:38473885
SP1 Mediated PIK3CB Upregulation Promotes Gastric Carcinogenesis., PMID:38356702
Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer., PMID:38044218
Ultrasound-mediated delivery of Pik3cb shRNA using magnetic nanoparticles for the treatment of in-stent restenosis in a rat balloon-injured model., PMID:37948449
For research use only. Not for human or drug use.
