Catalog No.
YHE35201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn345-Phe550
Predicted molecular weight
25.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42336
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphoinositide-3-kinase catalytic alpha polypeptide, PIK3CA, PtdIns-3-kinase subunit p110-alpha, PI3-kinase subunit alpha, p110alpha, Serine/threonine protein kinase PIK3CA, PI3K-alpha, Phosphoinositide 3-kinase alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
Investigation of cognitive enhancements and mechanisms of kinsenoside in APP/PS1 mice through network pharmacology, in vivo experiments, and machine learning., PMID:40513940
PIK3CA Mutations: Are They a Relevant Target in Adult Diffuse Gliomas?, PMID:40508087
Integrating metabolomics and network pharmacology analysis provides new insights into the lipid metabolism disorder of Abrus mollis., PMID:40505757
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction., PMID:40504949
EIF3B Promotes KRAS Gene Mutation-Driven Colon Adenocarcinoma Progression Through the TBK1 and PI3K/AKT Signaling Pathways., PMID:40503732
Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium., PMID:40501592
Network pharmacology and molecular docking-based characterization of the mechanisms through which Astragali Radix-Atractylodes macrocephala Koidz herb pair can treat membranous nephropathy., PMID:40489804
Intratumoral heterogeneity of cancer driver genomic alterations in myxoid liposarcomas., PMID:40489430
First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum., PMID:40481231
Clinicopathological and prognostic analysis of PIK3CA mutated invasive breast cancer in Chinese women., PMID:40472482
MET exon 14 skipping mutations in non-small-cell lung cancer a 3 years screening experience., PMID:40456875
Lipomatosis of Nerve Misdiagnosed as Primary Lymphedema: Report of Two Cases., PMID:40448973
Computational investigation and experimental validation of the molecular mechanism of Solanecio mannii aqueous roots extract against cervical cancer., PMID:40446016
Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro., PMID:40442218
Unveiling Isorhapontigenin's therapeutic potential in lung cancer via integrated network pharmacology, molecular docking, and experimental validation., PMID:40442126
Detection of hotspot mutations in oral cancer through Ion AmpliSeq™ cancer hotspot panel v.2.0: A circulating DNA fragmentomics approach in the Northeast Indian population., PMID:40440828
Genomic and proteomic profiling of GATA3 mutant metastatic hormone receptor-positive breast cancer and impact on clinical outcomes., PMID:40439821
Mutational analysis and protein expression of PI3K/AKT pathway in four mucinous cystadenocarcinoma of the breast., PMID:40437613
Deciphering the Regulatory Potential of Antioxidant and Electron-Shuttling Bioactive Compounds in Oolong Tea., PMID:40427676
Gastric Carcinoma., PMID:40423781
[Tiaozhou Ziyin recipe for treatment of premature ovarian insufficiency: efficacy, safety and mechanism]., PMID:40415424
Integrating LC-MS and molecular docking technology to investigate the effect of Spatholobi caulis flavonoids in alleviating primary dysmenorrhea via regulating the RhoA/ROCK pathway., PMID:40414437
TP53 Mutations and Phosphatidylinositol 3-Kinase/AKT Pathway Alterations Are Key Determinants of Breast Cancer Outcome Independent of Subtype and Stage., PMID:40403210
Shared neoantigens' atlas for off-the-shelf cancer vaccine development., PMID:40390041
MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma., PMID:40382983
Molecular and clinicopathological characteristics of invasive breast cancers with HER2-ultralow expression., PMID:40379141
ESR1 testing on FFPE samples from metastatic lesions in HR + /HER2- breast cancer after progression on CDK4/6 inhibitor therapy., PMID:40369610
Real-world evidence couples genomic biomarkers with therapeutic outcomes for canine hemangiosarcoma., PMID:40368987
Radiation-Induced Synchronous Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Clinical, Morphological, and Genetic Insights., PMID:40362680
Assessing the toxicological effects and mechanism of plasticizer exposure on inflammatory bowel disease based on network toxicology and molecular docking., PMID:40354873
Ubiquitous expression of an activating mutation in the Pik3ca gene reprograms glucose and lipid metabolism in mice., PMID:40354343
Unlocking the Potential of Alpelisib in Breast Cancer: A Comprehensive Review., PMID:40350259
Alpelisib in pediatric PIK3CA- and TIE-2-mutant vascular anomalies: a case series on safety, efficacy, and drug exposure., PMID:40346819
Capivasertib plus fulvestrant in patients with HR-positive/HER2-negative advanced breast cancer: phase 3 CAPItello-291 study extended Chinese cohort., PMID:40346047
Colorectal Cancer Cells-Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment., PMID:40344411
Molecular Subtype and Mutational Profile of Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia., PMID:40341112
Berberine promotes apoptosis and inhibits the migration of oral squamous carcinoma cells through inhibition of the RAGE/PI3K/AKT/mTOR pathway., PMID:40339228
Therapeutic efficacy of TMTP1-modified EVs in overcoming bone metastasis and immune resistance in PIK3CA mutant NSCLC., PMID:40328748
Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights., PMID:40327992
High frequency of the PIK3CA H1047L mutation in Indonesian breast cancer across molecular subtypes., PMID:40323930
Comprehensive computational analysis of deleterious nsSNPs in PTEN gene for structural and functional insights., PMID:40321699
Predicting and Confirming Bioequivalence of Alpelisib Oral Granules and Tablets for Patients With PIK3CA-Related Disorders., PMID:40307580
The SGK3/GSK3β/β-catenin signaling promotes breast cancer stemness and confers resistance to alpelisib therapy., PMID:40303291
[Detection of PIK3CA gene mutation by fluorescence PCR and its application in molecular diagnosis of macrodactyly]., PMID:40302584
[Characterization of PIK3CA/AKT1/PTEN gene mutations in hormone receptor- positive/HER2-negative breast cancer]., PMID:40302580
Search for Mutations Connected With Non-Response to Anti-EGFR Therapy in mCRC in the Morphologically Defined Regions of Primary Tumours., PMID:40302146
Molecular characteristics and responses to EGFR tyrosine kinase inhibitors in non-small cell lung cancer patients with EGFR exon 19 insertions., PMID:40301895
Development of Acquired Resistance in Alpelisib-treated Gastric Cancer Cells With PIK3CA Mutations and Overcoming Strategies., PMID:40295072
A review of epilepsy syndromes and epileptogenic mechanism affiliated with brain tumor related genes., PMID:40294709
Piperine derivative, (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-(2-hydroxyphenyl)penta-2,4-dienamide, exerted cytotoxic activity toward MCF-7 breast cancer cells via Apoptosis: Gene expression and biomolecular change study., PMID:40294461
For research use only. Not for human or drug use.
