Catalog No.
YHD44701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly33-Asp168
Predicted molecular weight
17.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21246
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Heparin-binding neurite outgrowth-promoting factor 1, Heparin-binding brain mitogen, PTN, HBGF-8, Pleiotrophin, Heparin-binding growth factor 8, HBBM, HBNF-1, NEGF1, Osteoblast-specific factor 1, HBNF, HBNF1, Heparin-binding growth-associated molecule, HB-GAM, OSF-1, Heparin-binding neurite outgrowth-promoting factor
The lncrna HMMR-AS1 promotes the malignant progression of ovarian cancer cells by regulating the miR-627-3p/PTN axis., PMID:40462168
Regulation of Pleiotrophin and PTPRZ1 Expression by Hypoxia to Restrict Hypoxia-Induced Cell Migration., PMID:40361445
Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential., PMID:40340952
Functional Specificity of Astrocyte Subtypes in Alzheimer's Disease: Decoding Disease Mechanisms Through Network-based Analysis of Integrated Single-Nuclei Multi-Omic Data., PMID:40301248
Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV., PMID:40274826
Ping pong chrysanthemum-like Bi-BiOI and ternary core-shell structured Pd@AuPt based dual-electric signal outputs biosensor for accurate detection of CA19 - 9., PMID:40261434
Plasma proteomic biomarkers predict therapeutic responses in advanced biliary tract cancer patients receiving Camrelizumab plus the GEMOX treatment., PMID:40195413
Tenacissoside G reverses paclitaxel resistance by inhibiting Src/PTN/P-gp signaling axis activation in ovarian cancer cells., PMID:40195205
Rethinking HIV treatment: How non-integrase strand regimens may hold the key to better immune health., PMID:40156175
The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes., PMID:40140583
Study on DNA Damage Gene in Spermatogonial Stem Cells from Idiopathic Nonobstructive Azoospermia: A Bioinformatics Investigation Based on scRNA-seq Data., PMID:40101697
Topical delivery of pterostilbene nanoemulgel ameliorates imiquimod-induced psoriasis-like skin inflammation in mice., PMID:40091821
Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice., PMID:40087317
PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior., PMID:40069581
CD44+ cells enhance pro-tumor stroma in the spatial landscape of colorectal cancer leading edge., PMID:40069574
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2., PMID:39938515
Midkine-a interacts with Ptprz1b to regulate neural plate convergence and midline formation in the developing zebrafish hindbrain., PMID:39924070
Barcoded screening identifies nanocarriers for protein delivery to kidney., PMID:39837887
The roles of pleiotrophin in brain injuries: a narrative review of the literature., PMID:39829367
A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release., PMID:39827209
MMFuncPhos: A Multi-Modal Learning Framework for Identifying Functional Phosphorylation Sites and Their Regulatory Types., PMID:39804866
An update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia., PMID:39798899
PTN secreted by cardiac fibroblasts promotes myocardial fibrosis and inflammation of pressure overload-induced hypertrophic cardiomyopathy through the PTN-SDC4 pathway., PMID:39765325
Calcium/calmodulin-dependent protein kinase II α and β differentially regulate mammalian sleep., PMID:39757286
Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches., PMID:39740665
Astrocyte-derived PTN alleviates deficits in hippocampal neurogenesis and cognition in models of multiple sclerosis., PMID:39729991
Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus., PMID:39722335
Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice., PMID:39712494
Unveiling Key Genes Modulating Retinal Cell Survival and Autophagy in Glaucoma., PMID:39695008
Pleiotrophin Prevents H2O2-Induced Senescence of Dental Pulp Stem Cells., PMID:39668573
Pleiotrophin Overexpression Reduces Adolescent Ethanol Consumption and Modulates Ethanol-Induced Glial Responses and Changes in the Perineuronal Nets in the Mouse Hippocampus., PMID:39654349
Pharmacotherapeutic potential of pratensein to avert metribuzin instigated hepatotoxicity via regulating TGF-β1, PI3K/Akt, Nrf-2/Keap-1 and NF-κB pathway., PMID:39603025
Simulated microgravity environment inhibits matrix mineralization during the osteoblast to osteocyte differentiation., PMID:39550861
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies., PMID:39546031
Aged hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment., PMID:39540334
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins., PMID:39525569
The Biomarkers in Extreme Longevity: Insights Gained from Metabolomics and Proteomics., PMID:39512690
Single-cell and spatial transcriptomes reveal the impact of maternal low protein diet on follicular cell composition and ovarian micro-environment in the offspring., PMID:39490908
Advantageous effects of rumen-protected phytonutrients from tropical plant extracts on rumen fermentation efficiency and methane mitigation using in vitro fermentation technique., PMID:39483013
Intra-channel bi-epitopic crosslinking unleashes ultrapotent antibodies targeting NaV1.7 for pain alleviation., PMID:39461335
Constitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice., PMID:39456743
Pharmacologic Induction of ERα SUMOylation Disrupts Its Chromatin Binding., PMID:39432240
Socially induced plasticity of the posterior tuberculum and motor behavior in zebrafish (Danio rerio)., PMID:39422204
Pleiotrophin Activates cMet- and mTORC1-Dependent Protein Synthesis through PTPRZ1-The Role of ανβ3 Integrin., PMID:39409168
Effects of pleiotrophin (PTN) on the FAK inhibitor Y15 in breast cancer cells., PMID:39322128
PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1., PMID:39285301
Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila., PMID:39277611
Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling., PMID:39265445
Pleiotrophin modulates acute and long-term LPS-induced neuroinflammatory responses and hippocampal neurogenesis., PMID:39255863
Recurrent endothelin-1 mediated vascular insult leads to cognitive impairment protected by trophic factor pleiotrophin., PMID:39197707
For research use only. Not for human or drug use.
