Catalog No.
YHD34501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser224-Ile502
Predicted molecular weight
34.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P19525
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase R, PRKR, Eukaryotic translation initiation factor 2-alpha kinase 2, Interferon-induced, double-stranded RNA-activated protein kinase, Protein kinase RNA-activated, EIF2AK2, Tyrosine-protein kinase EIF2AK2, p68 kinase, PKR, P1/eIF-2A protein kinase, Interferon-inducible RNA-dependent protein kinase, eIF-2A protein kinase 2
Deciphering the multifaceted role of double-stranded RNA sensor protein kinase R: pathophysiological function beyond the antiviral response., PMID:40444707
Super-Enhancer-Driven HCG20 Promotes Pulmonary Hypertension Through U2AF2 Splicing., PMID:40433695
New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics., PMID:40421421
Global translational regulation by Prkra: Is PKR no longer needed?, PMID:40378825
Using the Ratio of Phosphorylated to Non-phosphorylated Forms of Stress Kinase PKR as a Potential Diagnostic Test for ME/CFS., PMID:40372675
Shared circulating diagnostic biomarkers and molecular mechanisms in ischemic stroke and systemic lupus erythematosus., PMID:40313968
Unravelling the role of protein kinase R (PKR) in neurodegenerative disease: a review., PMID:40205152
Effective recognition of double-stranded RNA does not require activation of cellular inflammation., PMID:40203104
PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration., PMID:40199855
ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication., PMID:40198737
Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA., PMID:40185749
Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma., PMID:40135601
Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis., PMID:40096172
Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling., PMID:40050622
Calcium release from damaged lysosomes triggers stress granule formation for cell survival., PMID:39962896
Reduced White Matter Damage and Lower Neuroinflammatory Potential of Microglia and Macrophages in Hri/Eif2ak1 -/- Mice After Contusive Spinal Cord Injury., PMID:39760211
Multi-Omics Study Reveals Nc886/vtRNA2-1 as a Positive Regulator of Prostate Cancer Cell Immunity., PMID:39723625
Heart Failure Is Closely Associated With the Expression Characteristics of Type I Interferon-Related Genes., PMID:39704101
A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease., PMID:39665604
Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity., PMID:39636299
Treponema Pallidum protein Tp47 triggers macrophage inflammatory senescence via PKM2-mediated metabolic reprogramming., PMID:39581401
Analysis of the relationships between interferon-stimulated genes and anti-SSA/Ro 60 antibodies in primary Sjögren's syndrome patients via multiomics and machine learning methods., PMID:39577221
Calcium signaling from damaged lysosomes induces cytoprotective stress granules., PMID:39533058
PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis., PMID:39532917
Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic., PMID:39531012
Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA., PMID:39512178
Protein phosphatase 1 suppresses PKR/EIF2α signaling during human cytomegalovirus infection., PMID:39470211
Elucidating the role of PPARG inhibition in enhancing MERS virus immune response: A network pharmacology and computational drug discovery., PMID:39437592
The Versatile Roles of nc886, a Fascinating and Peculiar Regulatory Non-Coding RNA, in Cancer., PMID:39409154
Activation of PKR by a short-hairpin RNA., PMID:39384561
EIF2AK2 protein targeted activation of AIM2-mediated PANoptosis promotes sepsis-induced acute kidney injury., PMID:39311631
Identification and Validation of IFI44 as a Novel Biomarker for Primary Sjögren's Syndrome., PMID:39219820
[Myxovirus resistance protein A (MxA) induces the expression of interferon-stimulated genes in HepG2 cells by enhancing the activity of the interferon-stimulated response element (ISRE)]., PMID:39215668
Interleukin-8 in HepG2 cells: Enhancing antiviral proteins in uninfected cells but promoting HBV replication in infected cells., PMID:39083972
EPSTI1 promotes osteoclast differentiation and bone resorption by PKR/NF-κB signaling., PMID:39083969
Deciphering the molecular nexus between Omicron infection and acute kidney injury: a bioinformatics approach., PMID:39027131
Molecular insights into programmed cell death in esophageal squamous cell carcinoma., PMID:39006030
[Research Advances in the Association Between Alzheimer's Disease and Double-Stranded RNA-Dependent Protein Kinase]., PMID:38953267
LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response., PMID:38951609
Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrest., PMID:38917323
A frameshift mutation in the murine Prkra gene causes dystonia and exhibits abnormal cerebellar development and reduced eIF2α phosphorylation., PMID:38895245
Identification and Validation of PKR as a Direct Target for the Novel Sulfonamide-Substituted Tetrahydroquinoline Nonselective Inhibitor of the NLRP3 Inflammasome., PMID:38855903
Dysregulated RNA editing of EIF2AK2 in polycystic ovary syndrome: clinical relevance and functional implications., PMID:38853264
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells., PMID:38825632
Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer., PMID:38800011
Calreticulin regulates the expression of MMP14 and ADAR1 through EIF2AK2 signaling to promote the proliferation and progression of malignant melanoma cells., PMID:38766853
The impact of single-stranded RNAs on the dimerization of double-stranded RNA-dependent protein kinase PKR., PMID:38761636
C16, a PKR inhibitor, suppresses cell proliferation by regulating the cell cycle via p21 in colorectal cancer., PMID:38641657
Caspase-mediated processing of TRBP regulates apoptosis during viral infection., PMID:38636948
Bioinformatics and system biology approach to identify the influences among COVID-19, influenza, and HIV on the regulation of gene expression., PMID:38601162
For research use only. Not for human or drug use.
