Catalog No.
YHD14601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys170-Leu312
Predicted molecular weight
18.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16050
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Arachidonate omega-6 lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type, Hepoxilin A3 synthase Alox15, 12-LOX, 15-LOX-1, 15-LOX, Arachidonate 15-lipoxygenase, Polyunsaturated fatty acid lipoxygenase ALOX15, 12/15-lipoxygenase, Linoleate 13S-lipoxygenase, LOG15, ALOX15
ALOX15 Modulates Ferroptosis via the Reactive Oxygen Species-Mediated MAPK Pathway in Doxorubicin-Induced Cardiotoxicity., PMID:40455659
Qianshi Mixture Treats Diabetic Nephropathy by Regulating Lipid Metabolism Reprogramming and Inhibiting Oxidative Stress Damage., PMID:40418216
ALOX15-Mediated Neuron Ferroptosis Was Involved in Diabetic Peripheral Neuropathic Pain., PMID:40387519
Sevoflurane exposure triggers ferroptosis of neuronal cells initiated by the activation of ATM/p53 in the neonatal mouse brain via JNK/p38 MAPK-mediated oxidative DNA damage., PMID:40378436
Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway., PMID:40313934
Arachidonate 15-lipoxygenase: A promising therapeutic target for alleviating inflammation in acute pancreatitis., PMID:40309226
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) Induces Ferroptosis in Rat Cortical Neurons via p53-SLC7A11-ALOX12/p53-SAT1-ALOX15 Pathways., PMID:40288885
Comprehensive single-cell RNA-sequencing study of Tollip deficiency effect in IL-13-stimulated human airway epithelial cells., PMID:40269942
Integrated Metabolomics and Proteomics to Decipher Simiao Pill Improving Lipid Homeostasis through PTGES3-mediated Arachidonic Acid Metabolism in AIA Model., PMID:40237054
Ubiquitination of ALOX15 regulates endoplasmic reticulum stress in Schwann cells and experimental autoimmune neuritis (EAN) models., PMID:40222426
12-Lipoxygenase Inhibition Improves Glycemia and Obesity-associated Inflammation in Male Human Gene Replacement Mice., PMID:40186458
Novel 15-lipoxygenase-1 inhibitor protects cells from RSL3-induced cell death., PMID:40132494
Evaluation of several farnesyloxycarbostyril derivatives as potential 15-LOX-1 inhibitors for prostate cancer treatment., PMID:40057000
The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals., PMID:40044044
Fabry Disease Podocytes Reveal Ferroptosis as a Potential Regulator of Cell Pathology., PMID:39990892
Mitigating seizure-induced cognitive deficits in mice induced with pentylenetetrazol by roflumilast through targeting the NLRP3 inflammasome/BDNF/SIRT3 pathway and regulating ferroptosis., PMID:39983820
[Chitinase-like protein Ym2 regulates olfactory epithelium homeostasis and olfactory behavior in mice]., PMID:39979086
Prexasertib exerts a synergistic effect on the antitumor activity of Lenvatinib through ALOX15-mediated ferroptosis in hepatocellular carcinoma., PMID:39954659
The Protective Role of DDIT4 in Helicobacter pylori-induced Gastric Metaplasia Through Metabolic Regulation of Ferroptosis., PMID:39943905
Epigallocatechin-3-Gallate Promotes Recanalization in Deep Vein Thrombosis by Modulating Endothelial Progenitor Cell Ferroptosis Through the Nrf2 Pathway., PMID:39918021
Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet., PMID:39890062
Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway., PMID:39882747
The role of PCBP1 in carbon ion-induced ferroptosis and inhibition of lung adenocarcinoma proliferation., PMID:39845670
Optically controllable nanoregulators enable tumor-specific pro-ferroptosis lipometabolic reprogramming for in-situ adjuvant-free vaccination., PMID:39805186
A high seizure burden increases brain concentrations of specialized pro-resolving mediators in the Scn1a+/- mouse model of Dravet syndrome., PMID:39701411
Lactate-Dependent HIF1A Transcriptional Activation Exacerbates Severe Acute Pancreatitis Through the ACSL4/LPCAT3/ALOX15 Pathway Induced Ferroptosis., PMID:39676583
ALOX15-Driven Ferroptosis: The key target in Dihydrotanshinone I's epigenetic Battle in hepatic stellate cells against liver fibrosis., PMID:39675198
Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia., PMID:39638778
Hub genes, diagnostic model, and predicted drugs related to ferroptosis in chronic rhinosinusitis with nasal polyps., PMID:39612457
Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice., PMID:39608053
Structural and Functional Biology of Mammalian ALOX Isoforms with Particular Emphasis on Enzyme Dimerization and Their Allosteric Properties., PMID:39596127
Angiotensin II Induces Vascular Endothelial Dysfunction by Promoting Lipid Peroxidation-Mediated Ferroptosis via CD36., PMID:39595632
Transfection of 12/15-lipoxygenase effectively alleviates inflammatory responses during experimental acute pancreatitis., PMID:39563743
Identifying genetic targets in clinical subtypes of Parkinson's disease for optimizing pharmacological treatment strategies., PMID:39551798
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice., PMID:39531315
Crafting Molecular Tools for 15-Lipoxygenase-1 in a Single Step., PMID:39523872
Neobavaisoflavone Protects H9c2 Cells Against H2O2-Induced Mitochondrial Dysfunction Through ALOX15/PGC1-α Axis., PMID:39485322
SAT1/ALOX15 Signaling Pathway Is Involved in Ferroptosis After Skeletal Muscle Contusion., PMID:39457099
Compromised macrophages contribute to progression of MASH to hepatocellular carcinoma in FGF21KO mice., PMID:39441934
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication., PMID:39436697
Eicosanoid biosynthesizing enzymes in Prototheria., PMID:39389415
Reduced microRNA-744 expression in mast cell-derived exosomes triggers epithelial cell ferroptosis in acute respiratory distress syndrome., PMID:39378613
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury., PMID:39362839
Integrative multi-omics summary-based mendelian randomization identifies key oxidative stress-related genes as therapeutic targets for atrial fibrillation and flutter., PMID:39359474
The neo-potential therapeutic strategy in preeclampsia: Downregulated miR-26a-2-3p motivates endothelial cell injury by targeting 15-LOX-1., PMID:39357683
Lactoferrin alleviates gentamicin-induced acute kidney injury in rats by suppressing ferroptosis: Highlight on ACSL4, SLC7A11, NCOA4, FSP1 pathways and miR-378a-3p, LINC00618 expression., PMID:39357596
Targeting MGST1 Makes Non-Small Cell Lung Cancer Cells Sensitive to Radiotherapy by Epigenetically Enhancing ALOX15-Mediated Ferroptosis., PMID:39350424
Persistent desmoglein-1 downregulation and periostin accumulation in histologic remission of eosinophilic esophagitis., PMID:39343172
Chicoric acid acts as an ALOX15 inhibitor to prevent ferroptosis in asthma., PMID:39298822
Screening, identification and targeted intervention of necroptotic biomarkers of asthma., PMID:39270557
For research use only. Not for human or drug use.
