Catalog No.
YHC96101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu384-Ile732
Predicted molecular weight
41.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13010
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lupus Ku autoantigen protein p86, XRCC5, Thyroid-lupus autoantigen, Ku86, ATP-dependent DNA helicase 2 subunit 2, CTC85, G22P2, DNA repair protein XRCC5, 86 kDa subunit of Ku antigen, TLAA, Nuclear factor IV, CTC box-binding factor 85 kDa subunit, ATP-dependent DNA helicase II 80 kDa subunit, CTCBF, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining), X-ray repair cross-complementing protein 5
The mammalian Ku70 C-terminus SAP domain is required to repair DNA damage., PMID:40498075
Defective Repair of G1-Phase Double-Strand Breaks in WRNIP1/Ku70 Double Knockout Cells., PMID:40484680
Cluster analysis identifies three clinical patterns of patients with systemic autoimmune diseases and anti-Ku antibodies., PMID:40473271
Sequence Variation in X-ray Cross Complimenting (XRCC4, XRCC5, XRCC6 and XRCC7) Genes and the Risk of Gastrointestinal Cancer in South-Western Maharashtra: A Hospital Based Case-Control Study., PMID:40439368
Radiotherapy-induced TACC3 confers resistance of HCC to radiotherapy and enhances IL4-dependent immunosuppression to exacerbate hepatocarcinogenesis., PMID:40412795
Multi-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients beyond the Milan criteria., PMID:40355422
Targeting DNA damage sensors for cancer therapy., PMID:40339280
Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ., PMID:40328761
Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance., PMID:40254688
The DNA repair factor ku80 binds and activates the adhesion receptor ELTD1/ADGRL4., PMID:40245572
Hyperglycemia-induced DNA damage response activates DNA-PK complex to promote endothelial ferroptosis in type 2 diabetic cardiomyopathy., PMID:40225587
Comprehensive Proteomics and Machine Learning Analysis to Distinguish Follicular Adenoma and Follicular Thyroid Carcinoma from Indeterminate Thyroid Nodules., PMID:40205804
Evolutionary history of the DNA repair protein, Ku, in eukaryotes and prokaryotes., PMID:40131966
Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining., PMID:40114375
Association of XRCC gene family and CDH1 gene polymorphisms with gastric cancer risk in a Chinese population., PMID:40059436
Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody., PMID:40055307
ABCE1: A new cytoplasmic autoantibody target in systemic sclerosis-associated interstitial lung disease., PMID:39933610
Single-cell analysis reveals islet autoantigen's immune activation in type 1 diabetes patients., PMID:39896168
c-FLIP/Ku70 complex; A potential molecular target for apoptosis induction in hepatocellular carcinoma., PMID:39818348
BCAT1 Associates with DNA Repair Proteins KU70 and KU80 and Contributes to Regulate DNA Repair in T-Cell Acute Lymphoblastic Leukemia (T-ALL)., PMID:39769333
Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells., PMID:39762328
[Ku80 Inhibition Affects the Chemotherapeutic Sensitivity of T-Acute Lymphoblastic Leukemia Cell Line Jurkat]., PMID:39743252
The Ku protein family regulates hyperglycemia-induced vascular endothelial cell inflammation by modulating P300 levels., PMID:39743014
Ku70 targets BRD3-MYC/Cyclin D1 axis to drive hepatocellular carcinoma progression., PMID:39743013
Association between papillary thyroid cancer and XRCC6 gene polymorphisms in the Turkish population., PMID:39734356
Ku70 silencing aggravates oxygen-glucose deprivation/reperfusion-induced injury by activation of the p53 apoptotic pathway in rat cortical astrocytes., PMID:39715938
Multi-target therapeutic modulation with natural compounds towards DNA repair MRN-checkpoint sensor genes (MRN-CSGs) and oncogenic miRNAs in breast cancer patients: a Clinico-Informatic study., PMID:39568384
The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer., PMID:39488663
Tissue microarray analyses of the essential DNA repair factors ATM, DNA-PKcs and Ku80 in head and neck squamous cell carcinoma., PMID:39478631
Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma., PMID:39446493
Electrochemical response mechanism of DNA damaged cells: DNA damage repair and purine metabolism activation., PMID:39395363
Measuring protein stoichiometry with single-molecule imaging in Xenopus egg extracts., PMID:39389672
Negative feedback loop in the activation of non-homologous end joining DNA repair pathway in Helicobacter pylori infected patients with gastritis., PMID:39375425
EX527, a sirtuins 1 inhibitor, sensitizes T-cell leukemia to death receptor-mediated apoptosis by downregulating cellular FLICE inhibitory protein., PMID:39286953
Olaparib combined with CDK12-IN-3 to promote genomic instability and cell death in ovarian cancer., PMID:39247812
ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs., PMID:39226359
Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer., PMID:39190270
Critical residues in the Ku70 von Willebrand A domain mediate Ku interaction with the LigIV-XRCC4 complex in non-homologous end-joining., PMID:39151475
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals., PMID:39128395
PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer., PMID:39122729
In silico and in vitro characterization of the mycobacterial protein Ku to unravel its role in non-homologous end-joining DNA repair., PMID:39122073
SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis., PMID:39112443
Current status and prospect of the DNA double-strand break repair pathway in colorectal cancer development and treatment., PMID:39059591
Identification of the main barriers to Ku accumulation in chromatin., PMID:39058590
m6A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma., PMID:39054531
LINC-PINT plays an anti-tumor role in nasopharyngeal carcinoma by binding to XRCC6 and affecting its function., PMID:39032384
Tridecylcyclohexane in incomplete Freund's adjuvant is a critical component in inducing experimental autoimmune diseases., PMID:39030805
The DNA double-strand break repair proteins γH2AX, RAD51, BRCA1, RPA70, KU80, and XRCC4 exhibit follicle-specific expression differences in the postnatal mouse ovaries from early to older ages., PMID:39023827
Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy., PMID:39012547
MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-κB., PMID:38940672
For research use only. Not for human or drug use.
