Catalog No.
YHC90201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn2167-Ala2442
Predicted molecular weight
32.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11717
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IGF2R, M6P/IGF2 receptor, 300 kDa mannose 6-phosphate receptor, IGF-II receptor, M6PR, CI-MPR, CD222, Insulin-like growth factor 2 receptor, MPR 300, M6P/IGF2R, MPRI, CI Man-6-P receptor, Insulin-like growth factor II receptor, Cation-independent mannose-6-phosphate receptor
Engineering IGF2 for Lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy., PMID:39969096
Tail Anchored protein insertion mediated by CAML and TRC40 links to neuromuscular function in mice., PMID:39823474
Functional analysis of fibroblasts and macrophages in head and neck paragangliomas., PMID:39619326
The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study., PMID:38701040
Dysfunction in IGF2R Pathway and Associated Perturbations in Autophagy and WNT Processes in Beckwith-Wiedemann Syndrome Cell Lines., PMID:38612397
CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis., PMID:38581244
AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter., PMID:38307383
Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma., PMID:36299463
Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity., PMID:34721393
Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation., PMID:34365465
Association of Genetic Variants in IGF2-Related Genes With Risk of Metabolic Syndrome in the Chinese Han Population., PMID:34093434
The unique molecular targets associated antioxidant and antifibrotic activity of curcumin in in vitro model of acute lung injury: A proteomic approach., PMID:33864298
Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate., PMID:33859256
Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery., PMID:33764774
Insulin-Like Growth Factor 2 As a Possible Neuroprotective Agent and Memory Enhancer-Its Comparative Expression, Processing and Signaling in Mammalian CNS., PMID:33673334
Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico., PMID:33595041
Does fresh or frozen embryo transfer affect imprinted gene expressions in human term placenta?, PMID:33571695
Transcriptomic characterization reveals prognostic molecular signatures of sorafenib resistance in hepatocellular carcinoma., PMID:33495404
Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells., PMID:33424850
The role of insulin-like growth factor in Acrochordon Etiopathology., PMID:33143702
Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor., PMID:32908216
Three critical clinicobiological phases of the human SARS-associated coronavirus infections., PMID:32894568
Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9., PMID:32877646
A radioligand binding assay for the insulin-like growth factor 2 receptor., PMID:32877466
Effect of prenatal bisphenol A exposure on early childhood body mass index through epigenetic influence on the insulin-like growth factor 2 receptor (IGF2R) gene., PMID:32645488
Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data., PMID:32596059
Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport., PMID:32397873
IGF-binding proteins 3 and 4 are regulators of sprouting angiogenesis., PMID:32133604
Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy., PMID:32075092
Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection., PMID:32041945
Indirect surface-enhanced Raman scattering assay of insulin-like growth factor 2 receptor protein by combining the aptamer modified gold substrate and silver nanoprobes., PMID:32040773
Loss of IGF2R indicates a poor prognosis and promotes cell proliferation and tumorigenesis in bladder cancer via AKT signaling pathway., PMID:31847523
Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy., PMID:31793167
Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins., PMID:31748500
The combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy., PMID:31584202
The role of insulin-like growth factor 2 receptor-mediated homeobox gene expression in human placental apoptosis, and its implications in idiopathic fetal growth restriction., PMID:31418778
Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors., PMID:31391495
Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression., PMID:31388182
Childhood Obesity, Genetic Variation, and Dental Age., PMID:30992111
Expression and prognostic significance of insulin‑like growth factor-2 receptor in human hepatocellular carcinoma and the influence of transarterial chemoembolization., PMID:30720132
The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis., PMID:30657605
Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication., PMID:30541844
Serum and urinary levels of CD222 in cancer: origin and diagnostic value., PMID:29940770
Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA., PMID:29925683
Biotin-Chasing Assay to Evaluate uPAR Stability and Cleavage on the Surface of Cells., PMID:29318541
Unravelling novel functions of the endosomal transporter mannose 6-phosphate/insulin-like growth factor receptor (CD222) in health and disease: An emerging regulator of the immune system., PMID:28823520
The late endosomal transporter CD222 directs the spatial distribution and activity of Lck., PMID:25127865
Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells., PMID:22613725
Identification of a membrane proteomic signature for human embryonic stem cells independent of culture conditions., PMID:19383402
Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation., PMID:18073203
For research use only. Not for human or drug use.
