Catalog No.
YHC35401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly26-Ala503
Predicted molecular weight
56.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P08684
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CYPIIIA3, Cytochrome P450 3A4, 1,4-cineole 2-exo-monooxygenase, CYP3A4, Cytochrome P450 3A3, Cytochrome P450 NF-25, Cytochrome P450-PCN1, CYPIIIA4, 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase (sulfoxide-forming), Nifedipine oxidase, Quinine 3-monooxygenase, CYP3A3, Cholesterol 25-hydroxylase, Cytochrome P450 HLp, Albendazole sulfoxidase
Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes., PMID:40507787
Discovery and structure-activity relationship studies of 3-pyridazinesulfonyl derivatives as a new class of inhibitors against NLRP3 inflammasome-dependent pyroptosis., PMID:40479892
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA., PMID:40466953
Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human)., PMID:40462586
Pharmacokinetics of midazolam and hepatic cytochrome P450 3A activity in an in vivo extracorporeal membrane oxygenation rat model., PMID:40461528
Drug-drug interactions between epidermal growth factor receptor tyrosine kinase inhibitors and rivaroxaban in vitro and in vivo., PMID:40460109
Lipidomics reveals effect of EHHADH in lung squamous cell., PMID:40450155
Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing., PMID:40436327
Effects of mallotus furetianus extract on CYP3A activities in rats., PMID:40425598
Mechanistic insights into Licorice-Evodiae Fructus interaction: UPLC-MS/MS-based hepatotoxic metabolite detection and CYP3A4 regulation study., PMID:40424879
Transcriptomic characterization of the synergy between human induced pluripotent stem cells-derived liver- and pancreas-on-chip coculture., PMID:40409528
Inhibition Mechanism of Ketamine-Apatinib by CYP2C9 and 3A4: A Prediction of Possible Drug-Drug Interaction., PMID:40396559
Discovery and evaluation of a novel selective fluorescent substrate for CYP3A4 based on sulfoxidation characteristics., PMID:40391516
Deciphering the Relative Contribution of CYP3A4 Versus P-Glycoprotein for the Shared Substrate Cyclosporine-Commentary on Lown et al., PMID:40388112
Metabolic activation and cytotoxicity of carvedilol mediated by cytochrome P450s in vitro and in vivo., PMID:40380998
Discovery and optimization of 2-pyridones as dual h-DHFR/EGFRTK inhibitors with immunomodulatory potential; design, synthesis, anti-proliferative activity, and apoptosis inducer., PMID:40378576
Enantioselective in vitro metabolism of the fungicide penconazole by human liver microsomes and in vitro-in vivo extrapolation of hepatic clearance., PMID:40375401
Drug-Drug interactions and special considerations in breast cancer patients treated with CDK4/6 inhibitors: A comprehensive review., PMID:40367730
Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric disorders., PMID:40367121
Mono-CYP CHO Model: A Recombinant Chinese Hamster Ovary Cell Platform for Investigating CYP-Specific Tamoxifen Metabolism., PMID:40362231
Unraveling the molecular mechanisms of PFOA in clear cell renal cell carcinoma through network toxicology and molecular docking strategies., PMID:40359556
A Systematic Review and Classification of the Effects of P-glycoprotein Inhibitors and Inducers in Humans, Using Digoxin, Fexofenadine, and Dabigatran as Probe Drugs., PMID:40349292
HBV-induced N6 methyladenosine modification of PARP1 enhanced AFB1-related DNA damage and synergistically contribute to HCC., PMID:40344782
Thiol esters as chemical warheads of SARS-CoV-2 main protease (3CLpro) peptide-like inhibitors., PMID:40344734
Gene Polymorphisms Play an Important Role in the Drug Interaction Between Posaconazole and Tacrolimus in Renal Transplant Patients., PMID:40341589
Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese., PMID:40336126
Influences of Magnesium Isoglycyrrhizinate on the Pharmacokinetics of Almonertinib in Rats and Its Potential Mechanisms., PMID:40331403
Alleles of CYP3A5 and their association with renal function in chronic kidney disease., PMID:40330700
Structure-Guided Optimization of 2-Aminoquinazoline Hematopoietic Progenitor Kinase 1 Inhibitors for Improved Oral Bioavailability and Synergistic Antitumor Immunity., PMID:40325350
Drug Interactions of Imperatorin and Curcumin on Macitentan in vitro and in vivo., PMID:40322036
Inhibitory effect of carvedilol on bedaquiline metabolism in vitro and in vivo., PMID:40321826
A genetic algorithm-based approach for quantitative prediction of drug-drug interactions caused by cytochrome P450 3A inhibitors and inducers in dogs and cats., PMID:40311857
Next-generation rifamycins for the treatment of mycobacterial infections., PMID:40310456
Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data., PMID:40299245
Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population., PMID:40297930
Capillary Sampling Enables Venetoclax Concentration Measurement in Acute Myeloid Leukaemia Within Academic Multicentre Trial., PMID:40289318
Integrative CYP450 and network pharmacology approach for the assessment of Corilagin's influence on Sitagliptin pharmacokinetics., PMID:40287102
Effect of ponatinib on the metabolism of cariprazine in vitro and in vivo and the underlying mechanism., PMID:40286877
Determination and Disposition of the Aromatase Inhibitor Exemestane in CYP3A-Deficient Mice., PMID:40286062
Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy., PMID:40284418
Risk assessment of CYP3A induction by ginsenoside's metabolites from oral Panax notoginseng (sanqi) extract., PMID:40274033
Extrapolation of Midazolam Disposition in Neonates Using Physiological-Based Pharmacokinetic/Pharmacodynamic Modeling., PMID:40272270
Tanshinone IIA Improves Intestinal Barrier Integrity in Septic Rats., PMID:40267092
Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account., PMID:40261922
Phenoconversion of CYP3A4, CYP2C19 and CYP2D6 in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the PEGASUS Study., PMID:40259519
Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates., PMID:40258480
Decoding Allosteric Effects of Missense Variations in Drug Metabolism: Afrocentric CYP3A4 Alleles Explored., PMID:40252954
Comparison of the impact of chlordecone and its metabolite chlordecol on genes involved in pesticide metabolism in HepG2 cell line., PMID:40252817
QM/MM Study of the Metabolic Oxidation of 6',7'-Dihydroxybergamottin Catalyzed by Human CYP3A4: Preferential Formation of the γ-Ketoenal Product in Mechanism-Based Inactivation., PMID:40249700
Erlotinib-A substrate and inhibitor of OATP2B1: pharmacokinetics and CYP3A-mediated metabolism in rSlco2b1-/- and SLCO2B1+/+ rats., PMID:40239314
For research use only. Not for human or drug use.
