Catalog No.
YHB86701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser30-Lys430
Predicted molecular weight
47.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P00505
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fatty acid-binding protein, mAspAT, Kynurenine aminotransferase IV, Aspartate aminotransferase, mitochondrial, FABPpm, KYAT4, Kynurenine aminotransferase 4, Kynurenine--oxoglutarate transaminase 4, GOT2, Glutamate oxaloacetate transaminase 2, Transaminase A, Kynurenine--oxoglutarate transaminase IV, Plasma membrane-associated fatty acid-binding protein, FABP-1
Integrated Amino Acid Profiling and 4D-DIA Proteomics Reveal Protein Quality Divergence and Metabolic Adaptation in Cordyceps Species., PMID:40422699
GOT2 Elevation Mediated by YY1 Promotes the Tumorigenesis and Immune Escape of Lung Adenocarcinoma., PMID:40342193
Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma., PMID:40307857
Uncoupling protein 3 protects against pathological cardiac hypertrophy via downregulation of aspartate., PMID:40037428
Mitochondrial aspartate aminotransferase (GOT2) protein as a potential cryodamage biomarker in rooster spermatozoa cryopreservation., PMID:39721280
Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption., PMID:39494721
Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach., PMID:39350574
Plasma proteomics implicate glutamic oxaloacetic transaminases as potential markers for acute myocardial infarction., PMID:39173902
Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications., PMID:39160196
Integrative Proteomics-Metabolomics of In Vitro Degeneration of Cardiovascular Cell Lines., PMID:39110328
Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis., PMID:39009651
Unveiling novel targets in melanoma under melanogenesis stimulation and photodynamic therapy by redox proteomics., PMID:38961772
Elucidating the role of liver enzymes as markers and regulators in ovarian cancer: a synergistic approach using Mendelian randomization, single-cell analysis, and clinical evidence., PMID:38915066
Effect of the mitochondrial transaminase (GOT2) on membrane potential-sensitive respiration in mitochondria of differentiated C2C12 muscle cells., PMID:38646781
Pan-cancer molecular signatures connecting aspartate transaminase (AST) to cancer prognosis, metabolic and immune signatures., PMID:38496547
Integrated transcriptomics and proteomics analysis reveals muscle metabolism effects of dietary Ulva lactuca and ulvan lyase supplementation in weaned piglets., PMID:38409238
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people., PMID:38277453
Using meta-analysis and machine learning to investigate the transcriptional response of immune cells to Leishmania infection., PMID:38190401
Surgical resection of lung cancer inhibits mRNA expression of GOT2 gene encoding kynurenine aminotransferase in leukocytes., PMID:38153082
Low expression of GOT2 promotes tumor progress and predicts poor prognosis in hepatocellular carcinoma., PMID:38095985
Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy., PMID:38053021
A novel metabolism-related gene signature in patients with hepatocellular carcinoma., PMID:38025761
Exploring the role of lactylation-related genes in osteosarcoma: A deep dive into prognostic significance and therapeutic potential., PMID:38009602
Developmental and epileptic encephalopathy 82 (DEE82) with novel compound heterozygous mutations of GOT2 gene., PMID:37977948
Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells., PMID:37684043
System analysis based on glutamine catabolic-related enzymes identifies GPT2 as a novel immunotherapy target for lung adenocarcinoma., PMID:37657356
Therapeutic targeting of FUBP3 phase separation by GATA2-AS1 inhibits malate-aspartate shuttle and neuroblastoma progression via modulating SUZ12 activity., PMID:37537343
Genome-Wide Association Analysis of Muscle pH in Texel Sheep × Altay Sheep F2 Resource Population., PMID:37443959
Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence., PMID:37267176
A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease., PMID:37265567
TLR4 activation by lysozyme induces pain without inflammation., PMID:37197666
Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis., PMID:37108362
Circ_0006220 Contributes to NSCLC Progression through miR-342-3p/GOT2 Axis., PMID:36575008
STXBP3 and GOT2 predict immunological activity in acute allograft rejection., PMID:36532048
Combined proteomics and single cell RNA-sequencing analysis to identify biomarkers of disease diagnosis and disease exacerbation for systemic lupus erythematosus., PMID:36524113
Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: Divergent control in skeletal muscle and brown adipose tissue., PMID:36272463
GOT2: An Unexpected Mediator of Immunosuppression in Pancreatic Cancer., PMID:36196574
Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier., PMID:36079864
GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors., PMID:35895805
A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity., PMID:35894778
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context., PMID:35815941
Integrated proteomic analysis to explore the molecular regulation mechanism of IL-33 mRNA increased by black carbon in the human endothelial cell line EA.hy926., PMID:35776887
Expression of GOT2 Is Epigenetically Regulated by DNA Methylation and Correlates with Immune Infiltrates in Clear-Cell Renal Cell Carcinoma., PMID:35735610
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia., PMID:35726024
Thyroid Hormone Receptor Isoforms Alpha and Beta Play Convergent Roles in Muscle Physiology and Metabolic Regulation., PMID:35629909
BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity., PMID:35507536
Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia., PMID:35460704
A pathway-guided strategy identifies a metabolic signature for prognosis prediction and precision therapy for hepatocellular carcinoma., PMID:35286894
Machine learning-based predictions of dietary restriction associations across ageing-related genes., PMID:34983372
Comprehensive phytochemicals analysis and anti-myocardial ischemia activity of total saponins of American ginseng berry., PMID:34981530
For research use only. Not for human or drug use.
