Catalog No.
YHB82401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln233
Predicted molecular weight
28.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95999
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CED-3/ICH-1 prodomain homologous E10-like regulator, CLAP, B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, Cellular homolog of vCARMEN, cCARMEN, CIPER, Bcl-10, hCLAP, Cellular-E10, CARD-like apoptotic protein, c-E10, Mammalian CARD-containing adapter molecule E10, B-cell lymphoma/leukemia 10, mE10
The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes., PMID:40489607
A small-molecule inhibitor of BCL10-MALT1 interaction abrogates progression of diffuse large B cell lymphoma., PMID:40231473
Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling., PMID:39897024
Bruton's tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax., PMID:39894894
Adaptor protein 3BP2 regulates gene expression in addition to the ubiquitination and proteolytic activity of MALT1 in dectin-1-stimulated cells., PMID:39542253
Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB., PMID:39408697
A20 intrinsically influences human effector T-cell survival and function by regulating both NF-κB and JNK signaling., PMID:39359035
Sonic hedgehog signaling facilitates pyroptosis in mouse heart following ischemia/reperfusion via enhancing the formation of CARD10-BCL10-MALT1 complex., PMID:39343081
Biological function and potential application of PANoptosis-related genes in colorectal carcinogenesis., PMID:39237645
Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses., PMID:39169044
CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation., PMID:39145956
Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling., PMID:39118286
A novel MALT1 variant in an Egyptian patient presenting with exfoliative dermatitis: a case-based review., PMID:39017781
Baicalein alleviates palmitic acid-induced endothelial cell dysfunction via inhibiting endoplasmic reticulum stress., PMID:38905036
MALT1 substrate cleavage: what is it good for?, PMID:38863711
CARD11-BCL10-MALT1 Complex-Dependent MALT1 Activation Facilitates Myocardial Oxidative Stress in Doxorubicin-Treated Mice via Enhancing k48-Linked Ubiquitination of Nrf2., PMID:38814831
Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes., PMID:38797267
Study of individual domains contributing to MALT1 dimerization in BCL10-independent and dependent assembly., PMID:38714015
Differentially expressed proteins and microbial communities of the skin regulate disease resistance to Chinese tongue sole (Cynoglossus semilaevis)., PMID:38711504
Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB., PMID:38649988
Identification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells., PMID:38649144
CARMA3 Drives NF-κB Activation and Promotes Intervertebral Disc Degeneration: Involvement of CARMA3-BCL10-MALT1 Signalosome., PMID:38607566
The aryl hydrocarbon receptor-interacting protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor., PMID:38479600
Naturally occurring T cell mutations enhance engineered T cell therapies., PMID:38326614
FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling., PMID:38265263
Porcine β-Defensin 114: Creating a Dichotomous Response to Inflammation., PMID:38256090
MicroRNA‑155‑5p affects regulatory T cell activation and immunosuppressive function by targeting BCL10 in myasthenia gravis., PMID:38223327
MALT1 Protease Regulates T-Cell Immunity via the mTOR Pathway in Oral Lichen Planus., PMID:38159177
BCL10 Deficiency Presenting as Severe Combined Immunodeficiency Escaping Newborn Screening., PMID:38159157
In silico study of polyphenols as potential inhibitors of MALT1 protein in non-Hodgkin lymphoma., PMID:38155268
Inherited Human BCL10 Deficiencies., PMID:38129623
Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family., PMID:38098267
Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1?, PMID:37991197
Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma., PMID:37469257
Constructing ferroptosis-related competing endogenous RNA networks and exploring potential biomarkers correlated with immune infiltration cells in asthma using combinative bioinformatics strategy., PMID:37259023
Investigation of different genomic variants in familial Mediterranean fever cases with monoallelic MEFV mutation., PMID:37140617
Function and targeting of MALT1 paracaspase in cancer., PMID:37126937
Dimethyl Fumarate Suppresses the Proliferation of HTLV-1-infected T Cells by Inhibiting CBM Complex-triggered NF-B Signaling., PMID:37097671
CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport., PMID:37089447
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria., PMID:37030515
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions., PMID:36761777
The paracaspase MALT1 is a downstream target of Smad3 and potentiates the crosstalk between TGF-β and NF-kB signaling pathways in cancer cells., PMID:36708753
CARMA3: A potential therapeutic target in non-cancer diseases., PMID:36618379
The combination of gemcitabine and ginsenoside Rh2 enhances the immune function of dendritic cells against pancreatic cancer via the CARD9-BCL10-MALT1 / NF-κB pathway., PMID:36581220
The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection., PMID:36334414
Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates., PMID:36147669
Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling., PMID:36115893
Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL3 domain in solution., PMID:36094731
Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy., PMID:36056146
CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells., PMID:36009554
For research use only. Not for human or drug use.
