Catalog No.
YHB30701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn17-Glu302
Predicted molecular weight
34.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75787
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Renin/prorenin receptor, ER-localized type I transmembrane adapter, ATPase H(+)-transporting lysosomal accessory protein 2, CAPER, ATP6M8-9, Embryonic liver differentiation factor 10, ATP6AP2, ATPase H(+)-transporting lysosomal-interacting protein 2, V-ATPase M8.9 subunit, ATP6IP2, Renin receptor, N14F, ELDF10, Vacuolar ATP synthase membrane sector-associated protein M8-9
Collecting duct-derived (pro)renin receptor contributes to 2-kidney, 1-clip-induced ischemic nephropathy and renovascular hypertension in mice., PMID:40433846
(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice., PMID:40362413
The surface proteome of rabbit spermatozoa., PMID:40199101
Unravelling soluble (pro)renin receptor-mediated endothelial dysfunction., PMID:40187599
The relationship between kidney function and the soluble (pro)renin receptor in young adults: the African-PREDICT study., PMID:40181300
Apelin-13 exerts protective effects against acute kidney injury by lysosomal function regulation., PMID:40125924
Furin-mediated modification is required for epithelial sodium channel-activating activity of soluble (pro)renin receptor in cultured collecting duct cells., PMID:39871593
Vps4a Mediates a Unified Membrane Repair Machinery to Attenuate Ischemia/Reperfusion Injury., PMID:39764631
Pro-renin Receptor (PRR) as a Target to Reduce Non-alcoholic Fatty Liver Disease Post Liver Transplantation., PMID:39754755
Vacuolar H+-ATPase and Megalin-Mediated Prorenin Uptake: Focus on Elements Beyond the (Pro)Renin Receptor., PMID:39745029
Corrigendum: (Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway., PMID:39734411
Elevated Plasma Soluble (Pro)renin receptor as a potential indicator for heart failure., PMID:39730109
Soluble (pro)renin receptor (s(P)RR) levels in women carrying Aboriginal and/or Torres Strait Islander babies; the Gomeroi Gaaynggal study., PMID:39577063
(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway., PMID:39545058
Soluble (pro)renin receptor as a novel regulator of renal medullary Na+ reabsorption., PMID:39508841
GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions., PMID:39506854
Osteoclastic ATP6AP2 maintains β-catenin levels to prevent hyper-osteoclastic activation and trabecular bone-loss., PMID:39400061
Soluble (pro)renin receptor as a novel laboratory biomarker of atherosclerosis., PMID:39394818
New insights into prostate Cancer from the renin-angiotensin-aldosterone system., PMID:39368790
Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid., PMID:39342078
OXGR1-Dependent (Pro)Renin Receptor Upregulation in Collecting Ducts of the Clipped Kidney Contributes to Na+ Balance in Goldblatt Hypertensive Mice., PMID:39337535
PRR promotes hypertensive renal injury by activating Wnt/β-catenin signaling and inflammation infiltration in mice., PMID:39332780
Principle role of the (pro)renin receptor system in cardiovascular and metabolic diseases: An update., PMID:39321906
The renin-angiotensin-aldosterone system: An old tree sprouts new shoots., PMID:39306263
Renin and (pro)renin receptors induce vascular smooth muscle cell proliferation and neointimal hyperplasia by activating oxidative stress and inflammation., PMID:39212227
Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR., PMID:39195649
Collecting Duct Pro(Renin) Receptor Contributes to Unilateral Ureteral Obstruction-Induced Kidney Injury via Activation of the Intrarenal RAS., PMID:39171392
Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression., PMID:39134597
Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies., PMID:39093387
Downregulation of the (pro)renin receptor alleviates ferroptosis-associated cardiac pathological changes via the NCOA 4-mediated ferritinophagy pathway in diabetic cardiomyopathy., PMID:38963979
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner., PMID:38811544
Apelin-13: a novel approach to suppressing renin production in RVHT., PMID:38646785
X-Linked Epilepsies: A Narrative Review., PMID:38612920
Upregulation of the Renin-Angiotensin System Is Associated with Patient Survival and the Tumour Microenvironment in Glioblastoma., PMID:38607073
The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo., PMID:38605139
Assessment of the (Pro)renin Receptor Protein Expression in Organs., PMID:38534729
Kidney Renin-Angiotensin System: Lost in a RAS Cascade., PMID:38507510
Functional Roles of Furin in Cardio-Cerebrovascular Diseases., PMID:38481703
Renal Expression and Localization of the Receptor for (Pro)renin and Its Ligands in Rodent Models of Diabetes, Metabolic Syndrome, and Age-Dependent Focal and Segmental Glomerulosclerosis., PMID:38396894
Human soluble prorenin receptor expressed in mouse renal collecting duct shows sex-specific effect on cardiorenal function., PMID:38385173
(Pro)renin receptor signaling in hypothalamic tyrosine hydroxylase neurons is required for obesity-associated glucose metabolic impairment., PMID:38349753
Perinatal Use of Citrulline Rescues Hypertension in Adult Male Offspring Born to Pregnant Uremic Rats., PMID:38338891
Deletion of the prorenin receptor in the ureteric bud in mice inhibits Dot1/H3K79 pathway., PMID:38287105
Identification of Synonymous Pathogenic Variants in Monogenic Disorders by Integrating Exome with Transcriptome Sequencing., PMID:38280421
Elucidating the Role of Pro-renin Receptors in Pancreatic Ductal Adenocarcinoma Progression: A Novel Therapeutic Target in Cancer Therapy., PMID:38279719
Synonymous variants in the ATP6AP2 gene may lead to developmental and epileptic encephalopathy., PMID:38274877
Obesity Human Soluble Prorenin Receptor Expressed in Adipose Tissue Improves Insulin Sensitivity and Endothelial Function in Obese Female Mice., PMID:38260688
Aliskiren-Loaded Nanoparticles Downregulate (Pro)renin Receptor and ACE Gene Expression in the Heart of Spontaneously Hypertensive Rats: Effect on NADPH Oxidase., PMID:38255922
(Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway., PMID:38183100
Expanding the phenotype and metabolic basis of ATP6AP2-congenital disorder of glycosylation in a Chinese patient with a novel variant c.185G>A (p.Gly62Glu)., PMID:38075676
For research use only. Not for human or drug use.
