Catalog No.
YHA99101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp484-Val701
Predicted molecular weight
26.53 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60733
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Patatin-like phospholipase domain-containing protein 9, Group VI phospholipase A2, iPLA2-beta, PLA2G6, PLPLA9, Intracellular membrane-associated calcium-independent phospholipase A2 beta, GVI PLA2, CaI-PLA2, Palmitoyl-CoA hydrolase, 2-lysophosphatidylcholine acylhydrolase, 85/88 kDa calcium-independent phospholipase A2, PNPLA9
Genotype-Phenotype Relations for the Dystonia-Parkinsonism Genes GLB1, SLC6A3, SLC30A10, SLC39A14, and PLA2G6: MDSGene Systematic Review., PMID:40362326
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure., PMID:40344700
Study on the role and function of RRS1 in cutaneous squamous cell carcinoma., PMID:40339202
Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson's Disease., PMID:40282414
MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis., PMID:40271828
Elevated serum autotaxin levels and multiple system atrophy-like presentation in a patient with PLA2G6-associated neurodegeneration., PMID:40263418
Consensus Clinical Management Guideline for PLA2G6-Associated Neurodegeneration (PLAN)., PMID:40262088
Altered Mitochondrial Bioenergetics and Calcium Kinetics in Young-Onset PLA2G6 Parkinson's Disease iPSCs., PMID:40189860
Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review., PMID:40178685
MSI1 Accelerates Prostate Cancer Cell Proliferation, Migration and Glycolysis by Promoting ABHD2 Transcription., PMID:40067652
PLA2G6-associated Neurodegeneration: A Rare Case Report of Dystonia-Parkinsonism Phenotype with a Novel Genotypic Variant., PMID:39928007
Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes., PMID:39887724
Association of Novel Pathogenic Variant (p. Ile366Asn) in PLA2G6 Gene with Infantile Neuroaxonal Dystrophy., PMID:39796207
Genetic Landscape of Dystonia in Asian Indians., PMID:39749944
Genetic deletion of calcium-independent phospholipase A2γ protects mice from diabetic nephropathy., PMID:39480824
An estimation of global genetic prevalence of PLA2G6-associated neurodegeneration., PMID:39425167
Metabolic alterations in fibroblasts of patients presenting with the MPAN subtype of neurodegeneration with brain iron accumulation (NBIA)., PMID:39419454
Genetic architecture of a single cohort of 230 Indian Parkinson's Disease patients., PMID:39378566
Metabolic impairments in neurodegeneration with brain iron accumulation., PMID:39366438
Differential lipid signaling from CD4+ and CD8+ T cells contributes to type 1 diabetes development., PMID:39359722
iPLA2β loss leads to age-related cognitive decline and neuroinflammation by disrupting neuronal mitophagy., PMID:39294744
iPLA2β regulates the dual effects of arachidonic acid in thyroid cancer., PMID:39290130
Selective Reduction of Ca2+-Independent Phospholipase A2β (iPLA2β)-Derived Lipid Signaling From Macrophages Mitigates Type 1 Diabetes Development., PMID:39283670
Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy., PMID:39277575
Infantile Neuroaxonal Dystrophy: Case Report and Review of Literature., PMID:39202603
The Clinical, Radiological and Genetic Spectrum of PLA2G6-Associated Neurodegeneration: An Experience From a Tertiary Center., PMID:39184971
Mitochondria to plasma membrane redox signaling is essential for fatty acid β-oxidation-driven insulin secretion., PMID:39067330
Genetic Targets and Applications of Iron Chelators for Neurodegeneration with Brain Iron Accumulation., PMID:38911909
Whole-exome sequencing in a cohort of Chinese patients with isolated cervical dystonia., PMID:38845987
Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing., PMID:38764027
Knockdown of iPLA2γ enhances cisplatin-induced apoptosis by increasing ROS-dependent peroxidation of mitochondrial phospholipids in bladder cancer cells., PMID:38734266
Clinical, neuroimaging and genetic findings in Brazilian patients with neurodegeneration with brain iron accumulation., PMID:38582019
Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells., PMID:38579937
Expert Commentary: A new genetic variant, presenting as young onset rapidly progressive dementia and parkinsonism., PMID:38555267
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis., PMID:38383396
Mieap forms membrane-less organelles involved in cardiolipin metabolism., PMID:38322995
Generation of induced pluripotent stem cell line LNDWCHi001-A from a patient with early-onset Parkinson's disease carrying the homozygous c.1898C > T (p. A633V) mutation in the PLA2G6 gene., PMID:38215561
Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1α activation., PMID:38198970
Causal Effect of Lipoprotein-Associated Phospholipase A2 Activity on Ischemic Stroke: A Mendelian Randomization Study., PMID:38113871
Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer., PMID:38017485
Creation of a Rat Takotsubo Syndrome Model and Utilization of Machine Learning Algorithms for Screening Diagnostic Biomarkers., PMID:37901384
Diagnosis, treatment and genetic analysis of a child with infantile neuroaxonal dystrophy., PMID:37503585
Phenotype and genotype heterogeneity of PLA2G6-associated neurodegeneration in a cohort of pediatric and adult patients., PMID:37403138
Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naïve first-episode psychosis patients and nonadherent chronic psychosis patients., PMID:37290257
The role of the PLA2G6 gene in neurodegenerative diseases., PMID:37236368
Human induced pluripotent stem cell line (ONHi001-A) generated from a patient with infantile neuroaxonal dystrophy having PLA2G6 c.517C > T (p.Q173X) and c.1634A > G (p.K545R) compound heterozygous mutations., PMID:37209469
PLA2G6-associated late-onset parkinsonism in a Sudanese family., PMID:37139542
Whole-Exome Sequencing Study of Fibroblasts Derived From Patients With Cerebellar Ataxia Referred to Investigate CoQ10 Deficiency., PMID:37090936
For research use only. Not for human or drug use.
