Catalog No.
YHA92901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser6-Lys240
Predicted molecular weight
28.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60502
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OGA, Protein O-GlcNAcase, Meningioma-expressed antigen 5, Beta-N-acetylhexosaminidase, HEXC, N-acetyl-beta-glucosaminidase, KIAA0679, Nuclear cytoplasmic O-GlcNAcase and acetyltransferase, MEA5, MGEA5, Beta-hexosaminidase, NCOAT, Beta-N-acetylglucosaminidase, N-acetyl-beta-D-glucosaminidase
Sex alters thyroid hormone's effect on protein O-GlcNAcylation in the aged mouse heart., PMID:40495125
Decoding glycosylation in cardiovascular diseases: mechanisms, biomarkers, and therapeutic opportunities., PMID:40458788
SUMOylation targets O-GlcNAcase to chaperone-mediated autophagy., PMID:40449592
Elucidation of Molecular Mechanisms of Sulfated Oligoguluronic Acid on Mitigating Intestinal Inflammation and Enhancing Epithelial Barrier Function., PMID:40406814
OGT-mediated O-GlcNAc of PINK1 promotes the progression of obesity-related hypertension via regulating mitophagy., PMID:40380818
OGT Enhances Adriamycin Resistance of Breast Cancer by Promoting Glycolysis through MDM4 Upregulation in an O-GlcNAcylation-Dependent Manner., PMID:40372583
SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing., PMID:40265571
Downregulation of GFPT2 enhances cisplatin chemotherapy sensitivity in STK11/KRAS mutant non-small cell lung cancer by regulating the hexosamine biosynthesis pathway, resisting tumor growth., PMID:40253947
OGA promotes human dental pulp stem cell senescence and inhibits mitophagy by inhibition of O-GlcNAcylation of KLF2., PMID:40251583
Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila., PMID:40245499
In vivo quantification of [11C]BIO-1819578 in non-human primates, a novel radioligand for O-GlcNAcase., PMID:40219925
Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction., PMID:40200275
Dynamic O-GlcNAcylation and phosphorylation attract and expel proteins from RNA polymerase II to regulate mRNA maturation., PMID:40186208
Safety analysis of self-administered enzyme replacement therapy using data from the Fabry Outcome and Gaucher Outcome Surveys., PMID:40155993
Expression of O-GlcNAcylation in pulp tissue and dental pulp stem cells of healthy dental organs., PMID:40152124
Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy., PMID:40148470
Multi-omic biomarkers associated with multiple sclerosis: from Mendelian randomization to drug prediction., PMID:40108295
Characterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model., PMID:40021952
Glucose enrichment reduces lifespan and promotes tau phosphorylation in human tau-expressing C. elegans, unaffected by O-β-GlcNAcylation induction., PMID:39924618
Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis., PMID:39896100
O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury., PMID:39892583
Silencing of O-GlcNAc Transferase Attenuated O-GlcNAcylation and Metastatic Potentials of Melanoma Cells Through Suppression of Akt-NFκB Signaling Pathway., PMID:39878235
HMGB1 assists the predictive value of tumor PD-L1 expression for the efficacy of anti-PD-1/PD-L1 antibody in NSCLC., PMID:39853458
Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease., PMID:39823370
Fluoride Induces Toxic Effects on the A549 Pulmonary Cell Line at Non-cytotoxic Concentrations., PMID:39753787
Discovery and clinical translation of ceperognastat, an O-GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease., PMID:39748851
An Efficient and Accessible Hectogram-Scale Synthesis for the Selective O-GlcNAcase Inhibitor Thiamet-G., PMID:39713709
Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability., PMID:39667498
OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis., PMID:39659899
O-GlcNAcylation in ovarian tumorigenesis and its therapeutic implications., PMID:39616984
PERM1 regulates mitochondrial energetics through O-GlcNAcylation in the heart., PMID:39581161
Astragalus polysaccharide treatment relieves cerebral ischemia‒reperfusion injury by promoting M2 polarization of microglia by enhancing O-GlcNAcylation., PMID:39560836
Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability., PMID:39535175
Ultradeep O-GlcNAc proteomics reveals widespread O-GlcNAcylation on tyrosine residues of proteins., PMID:39531497
Opportunities for Therapeutic Modulation of O-GlcNAc., PMID:39509538
Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferase., PMID:39481848
SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing., PMID:39464125
O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis., PMID:39426963
The correlation between cellular O-GlcNAcylation and sensitivity to O-GlcNAc inhibitor in colorectal cancer cells., PMID:39413067
Loss of LRP1 Promotes Hepatocellular Carcinoma Progression via UFL1-Mediated Activation of NF-κB Signaling., PMID:39405202
O-GlcNAc participates in the meiosis of aging oocytes by mediating mitochondrial function., PMID:39405070
A case of MSI-high pancreatic body-tail cancer successfully treated with radical resection after pembrolizumab., PMID:39402396
O-GlcNAcylation of ribosome-associated proteins is concomitant with translational reprogramming during proteotoxic stress., PMID:39395807
Loss of O-GlcNAcylation modulates mTORC1 and autophagy in β cells, driving diabetes 2 progression., PMID:39388284
A phase III, open-label clinical trial evaluating pegunigalsidase alfa administered every 4 weeks in adults with Fabry disease previously treated with other enzyme replacement therapies., PMID:39381863
Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease., PMID:39345543
Impact of O -GlcNAcylation elevation on mitophagy and glia in the dentate gyrus., PMID:39345468
Systematic Evaluation of Affinity Enrichment Methods for O-GlcNAc Proteomics., PMID:39302247
Alternative splicing and intron retention: Their profiles and roles in cutaneous fibrosis of systemic sclerosis., PMID:39265192
Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma., PMID:39199296
For research use only. Not for human or drug use.
