Catalog No.
YHA56101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp256-Arg508
Predicted molecular weight
30.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15528
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
25-hydroxyvitamin D(3) 1-alpha-hydroxylase, CYP27B, CYP27B1, Cytochrome P450C1 alpha, Calcidiol 1-monooxygenase, Cytochrome P450VD1-alpha, Cytochrome p450 27B1, CYP1ALPHA, Cytochrome P450 subfamily XXVIIB polypeptide 1, 25-OHD-1 alpha-hydroxylase, VD3 1A hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Attenuative Effect of Grifola frondosa (Maitake Mushroom) on Severe DSS-Induced Colitis in Vitamin D-Deficient Mice., PMID:40509673
Genetic Polymorphism of CYP2R1, CYP27A1, CYP27B1, and Vitamin D Metabolites Plasma Levels in Patients with Cardiovascular Disease: A Pilot Study., PMID:40427592
1,25(OH)2D3 up-regulated mitochondrial dynamics and biogenesis to modulate steroidogenesis in the scent glands of muskrats (Ondatra zibethicus)., PMID:40398522
Association of Vitamin D receptor gene polymorphism and Vitamin D status to explore as a risk factor in Visceral Leishmaniasis and Post Kala Azar Dermal Leishmaniasis patients in endemic regions of Bihar., PMID:40381960
Induction of Cell Death and Regulation of Autocrine Vitamin D Metabolism in Cervical Cancer by Physiological and GI20 Doses of 25-Hydroxycholecalciferol., PMID:40362248
In Vitro Study of Vitamin D Effects on Immune, Endothelial, and Vascular Smooth Muscle Cells in Chronic Kidney Disease., PMID:40362207
Effect of cholecalciferol on immune and vascular function in non-diabetic chronic kidney disease., PMID:40342405
Vitamin D3, cholecalciferol via its hydroxylmetabolites, receptors and metabolizing enzymes modulates male reproductive functions., PMID:40320139
Helminth reshapes host gut microbiota and immunoregulation by deploying an antimicrobial program of innate immunity., PMID:40266093
Phenotypes and Genotypes of Children with Vitamin D-Dependent Rickets Type 1A: A Single Tertiary Pediatric Center in Vietnam., PMID:40218268
Genetic variants in vitamin D metabolism-related genes are associated with vitamin D status and adiposity markers., PMID:40187223
Association of PTH and vitamin D-related genes with dental development in Brazilian children: a cross-sectional study., PMID:40172435
Vitamin D and its analogs in immune system regulation., PMID:40148037
Vitamin D stimulates Il-15 synthesis in rodent muscle., PMID:40134939
Advance in candidate genes in mandibular retrognathism: A systematic review., PMID:40132276
The effect of vitamin D (1,25-(OH)2-D3) on human theca and granulosa cell function., PMID:40100123
Kidney deletions of Cyp27b1 fail to reduce serum 1,25(OH)2D3., PMID:40096920
The impact of inducible-whole body or intestine-specific Cyp24a1 gene knockout on vitamin D metabolism in mice., PMID:40096918
A Mechanistic Study of the Feasibility of Ursodeoxycholic Acid in the Treatment of Colon Adenocarcinoma., PMID:40093647
Divergent roles of 25-hydroxyvitamin D3 and 1α,25-dihydroxyvitamin D3 in neural fate determination: A CYP27B1-dependent neuron formation and VDR-dependent astrocyte development., PMID:40043620
Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis., PMID:40038731
Longitudinal Evaluation of Vitamin D, Parathyroid Hormone, Antimicrobial Peptides, and Immunomodulatory Genes in Hospitalized Foals., PMID:40008921
High-salt diets provoke phosphorus absorption from the small intestine in mice., PMID:39998332
Role of Cytochromes P450 in Intestinal Barrier Function: Possible Involvement in the Pathogenesis of Leaky Gut Syndrome., PMID:39971825
Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression., PMID:39952566
Hypophosphatemic rickets in an Italian multicentric cohort of 24 subjects: a clinical and molecular characterisation., PMID:39915350
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis., PMID:39895866
Effects of vitamin D and L-cysteine cosupplementation on circulating bioavailable and total 25-hydroxy-vitamin D, the free/total testosterone ratio and inflammatory biomarkers in healthy vitamin D-deficient African Americans: a placebo-controlled double-blind clinical trial., PMID:39882299
Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis., PMID:39844838
Vitamin D-related genetic variants and prostate cancer risk in Black men., PMID:39823710
The Expressions of the Immunity- and Muscle Development-Related Genes of 40-Day-Old Broilers Are Promoted in Response to the In Ovo and Dietary Supplemental Administration of Calcidiol in Conjunction with the In Ovo Administration of Marek's Disease Vaccine., PMID:39794953
Respiratory insufficiency as a rare presentation in a child with vitamin D-dependent rickets type 1., PMID:39778955
Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice., PMID:39688907
Dysregulated Vitamin D, CYP2R1, TCF7L2, and CCR5 Δ32 Gene Variations are Associated with Coronary Artery Disease., PMID:39600283
Vitamin D metabolism-related single nucleotide polymorphisms in Chronic Obstructive Pulmonary Disease risk., PMID:39583968
Impact of gene polymorphisms involved in the vitamin D metabolic pathway on the susceptibility to and severity of autism spectrum disorder., PMID:39550459
A Rare Case of Neuronal Ceroid Lipofuscinosis-Type 1 (NCL-1) with Vitamin D-Dependent Rickets-Type 1 (VDDR-1), Complex 1 Mitochondrial Deficiency, and Mixed Variant-Checkerboard and Phylloid Type of Pigmentary Mosaicism., PMID:39502845
Correlation between vitamin D metabolic pathway-related gene polymorphisms and cardiovascular disease., PMID:39494806
Crosstalk between 1,25(OH)2-Vitamin D3 and the growth factors EGF and PDGF-BB: Impact on CYP24A1 expression and cell proliferation., PMID:39447276
Investigating the Mechanisms of Anti-tumoral Effect of Combination Therapy of Calcitriol and Sodium Pentaborate Pentahydrate on HepG2 Hepatocellular Carcinoma Cells., PMID:39441231
The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells., PMID:39430127
SARS-CoV-2 infection causes a decline in renal megalin expression and affects vitamin D metabolism in the kidney of K18-hACE2 mice., PMID:39414885
In Vivo Contribution of Cyp24a1 Promoter Vitamin D Response Elements., PMID:39363152
Vitamin D3 reduces the expression of M1 and M2 macrophage markers in breast cancer patients., PMID:39333342
Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling., PMID:39321290
Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis., PMID:39320233
Efficacy of l-cysteine in increasing circulatory hydrogen sulfide, nitrite, and 25-hydroxyvitamin D levels in Zucker diabetic fatty rats and in vitro treatment of hydrogen sulfide and nitrite in upregulating vitamin D hydroxylase genes in monocytes., PMID:39245163
Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status., PMID:38999892
Exploring the role of vitamin D-VDR pathway in pemphigus foliaceous: a novel perspective on disease pathogenesis., PMID:38958777
Spatial detection and consequences of nonrenal calcitriol production as assessed by targeted mass spectrometry imaging., PMID:38916957
For research use only. Not for human or drug use.
