Catalog No.
YHA28101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr103-Arg419
Predicted molecular weight
38.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14733
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAPKK4, JNK-activating kinase 2, MAPK/ERK kinase 7, MAPKK 7, c-Jun N-terminal kinase kinase 2, JNKK2, SAPK kinase 4, MEK 7, MAP kinase kinase 7, SKK4, PRKMK7, Dual specificity mitogen-activated protein kinase kinase 7, Stress-activated protein kinase kinase 4, JNK kinase 2, MKK7, MAP2K7, MEK7, JNKK 2, SAPKK-4
Identification of common hub genes and construction of immune regulatory networks in aplastic anemia, myelodysplastic syndromes, and acute myeloid leukemia., PMID:40406144
BRD4/MAP2K7/PGF Signaling Axis Promotes Senescence and Extracellular Matrix Metabolism of Nucleus Pulposus Cells in Intervertebral Disk Degeneration., PMID:40130513
map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration., PMID:40096024
TC10 on endosomes regulates the local balance between microtubule stability and dynamics through the PAK2-JNK pathway and promotes axon outgrowth., PMID:40008675
Transcriptomic profiles of single-cell autophagy-related genes (ATGs) in lung diseases., PMID:39920481
BRCA1-Associated Protein-1 Inactivated Melanoma Arising in a Pre-existing Nevus With ALK Fusion and Low Tumor Mutational Burden., PMID:39912664
Pharmacological inhibition of the MAP2K7 kinase in human disease., PMID:39717752
miR-128-3p suppresses tumor growth and enhances chemosensitivity in tongue squamous cell carcinoma through MAP2K7 targeting., PMID:39476205
Integrative multi-target analysis of Urtica dioica for gout arthritis treatment: a network pharmacology and clustering approach., PMID:39351010
ALKBH5 Regulates Osteogenic Differentiation via the lncRNA/mRNA Complex., PMID:39311450
Proteomic changes of the bovine blood plasma in response to heat stress in a tropically adapted cattle breed., PMID:39149588
Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitors., PMID:39111728
LncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer., PMID:38698487
Gene expression profile of mitogen-activated kinases and microRNAs controlling their expression in HaCaT cell culture treated with lipopolysaccharide A and cyclosporine A., PMID:38445655
Changes in antioxidant status and DNA repair capacity are corroborated with molecular alterations in malignant thyroid tissue of patients with papillary thyroid cancer., PMID:37692064
Cross-species analysis of transcriptome emphasizes a critical role of TNF-α in mediating MAP2K7/AKT2 signaling in zearalenone-induced apoptosis., PMID:37549580
Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway., PMID:37367226
Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors., PMID:37197477
HER2-driven breast cancer suppression by the JNK signaling pathway., PMID:36656864
Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia., PMID:36399528
miRNome-transcriptome analysis unveils the key regulatory pathways involved in the tumorigenesis of tongue squamous cell carcinoma., PMID:36255066
Synaptotagmin 11 scaffolds MKK7-JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis., PMID:35768842
The EEF1AKMT3/MAP2K7/TP53 axis suppresses tumor invasiveness and metastasis in gastric cancer., PMID:35753528
Small Extracellular Vesicles From Brown Adipose Tissue Mediate Exercise Cardioprotection., PMID:35387487
The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task., PMID:35275161
Circular RNA ACTA1 Acts as a Sponge for miR-199a-5p and miR-433 to Regulate Bovine Myoblast Development through the MAP3K11/MAP2K7/JNK Pathway., PMID:35234473
Evolution of a New Testis-Specific Functional Promoter Within the Highly Conserved Map2k7 Gene of the Mouse., PMID:35069705
Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions., PMID:34639041
Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells., PMID:34502457
Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice., PMID:34502275
JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer., PMID:34236045
Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways., PMID:34124273
Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases., PMID:34062912
Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation., PMID:33891857
Dual inhibition of MEK1/2 and MEK5 suppresses the EMT/migration axis in triple-negative breast cancer through FRA-1 regulation., PMID:33876843
Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons., PMID:33744924
Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines., PMID:33611044
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength., PMID:33475086
Tiao Geng decoction inhibits tributyltin chloride-induced GT1-7 neuronal apoptosis through ASK1/MKK7/JNK signaling pathway., PMID:33338591
Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial-mesenchymal transition., PMID:33305380
Tumorigenic de-differentiation: the alternative splicing way., PMID:33235913
Development and validation of a novel survival model for head and neck squamous cell carcinoma based on autophagy-related genes., PMID:33227411
MKK7 deficiency in mature neurons impairs parental behavior in mice., PMID:33098150
Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice., PMID:32969030
Structural basis for producing selective MAP2K7 inhibitors., PMID:32931911
An autophagy-related model of 4 key genes for predicting prognosis of patients with laryngeal cancer., PMID:32791689
Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities., PMID:32783966
miR-331-3p is involved in glucocorticoid resistance reversion by rapamycin through suppression of the MAPK signaling pathway., PMID:32776229
Oleuropein protects against lipopolysaccharide-induced sepsis and alleviates inflammatory responses in mice., PMID:32710811
A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation., PMID:32601196
For research use only. Not for human or drug use.
