Catalog No.
YHA27101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu152
Predicted molecular weight
19.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14684
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PGES, PTGES, Prostaglandin E synthase, MPGES1, Microsomal prostaglandin E synthase 1, MGST1-L1, PIG12, p53-induced gene 12 protein, Glutathione transferase PTGES, MGST1L1, MPGES-1, Glutathione peroxidase PTGES, Microsomal glutathione S-transferase 1-like 1
Anti-inflammatory effect of photobiomodulation in the brain following local peripheral carrageenan-induced inflammation., PMID:40500489
Placental interleukin 1β signaling in canine pregnancy: differential effects during and after decidualization in vitro., PMID:40084938
Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition., PMID:40010271
LIN28B enhances the chemosensitivity of colon cancer cells via inducing genomic instability by upsetting the balance between the production and removal of reactive oxygen species., PMID:39986369
Structure Bioinformatics of Six Human Integral Transmembrane Enzymes and their AlphaFold3 Predicted Water-Soluble QTY Analogs: Insights into FACE1 and STEA4 Binding Mechanisms., PMID:39966220
Discovery of novel microsomal prostaglandin E2 synthase 1 (mPGES-1) inhibitors by a structurally inspired virtual screening study., PMID:39893902
Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization., PMID:39885565
Activation of the COX-2/mPGES-1/PGE-2 cascade through the NLRP3 inflammasome contributes to Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis., PMID:39832004
2-Phenylbenzothiazoles featuring heteroaryl sulfonamide end-capping substructures as developable mPGES-1 inhibitors., PMID:39817627
Inflammatory Response of THP1 and U937 Cells: The RNAseq Approach., PMID:39768153
5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates., PMID:39692230
Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever., PMID:39622054
Microsomal Prostaglandin E Synthase-1 Controls Colonic Prostaglandin E2 Production and Exerts a Protective Effect on Colitis Induced by Trinitrobenzene Sulfonic Acid in Mice., PMID:39596393
Spatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development., PMID:39581452
Roburic acid inhibits lung cancer metastasis and triggers autophagy as verified by network pharmacology, molecular docking techniques and experiments., PMID:39450260
Novel Synthesized Benzophenone Thiazole Hybrids Exhibited Ex Vivo and In Silico Anti-Inflammatory Activity., PMID:39424371
PTGES is involved in myofibroblast differentiation via HIF-1α-dependent glycolysis pathway., PMID:39417702
Pivotal roles for cancer cell-intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunity., PMID:39298269
Progressively Diminished Prostaglandin E2 Signaling in Concordance with Increasing Fibrosis in Ectopic Endometrium., PMID:39174854
In Vitro Bioassay for Damage-Associated Molecular Patterns Arising from Injured Oral Cells., PMID:39061769
Activation of the PGE2-EP2 pathway as a potential drug target for treating eosinophilic rhinosinusitis., PMID:39015572
Dexamethasone treatment influences tendon healing through altered resolution and a direct effect on tendon cells., PMID:38961188
Transcriptomic Analyses Reveal the Effects of Walnut Kernel Cake on Adipose Deposition in Pigs., PMID:38927603
Myeloid Cell mPGES-1 Deletion Attenuates Calcium Phosphate-induced Abdominal Aortic Aneurysm in Male Mice., PMID:38865056
Short preconditioning with TGFβ of equine adipose tissue-derived mesenchymal stem cells predisposes towards an anti-fibrotic secretory phenotype: A possible tool for treatment of endometrosis in mares., PMID:38805994
Epimedin B exerts an anti-inflammatory effect by regulating the MAPK/NF-κB/NOD-like receptor signalling pathways., PMID:38801842
Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration., PMID:38654287
Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors., PMID:38653151
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling., PMID:38583151
Multi-omics reveals that 5-O-methylvisammioside prevention acute liver injury in mice by regulating the TNF/MAPK/NF-κB/arachidonic acid pathway., PMID:38522313
Intermittent mild cold acclimation ameliorates intestinal inflammation and immune dysfunction in acute cold-stressed broilers by regulating the TLR4/MyD88/NF-κB pathway., PMID:38518665
Identification of Senescence-Associated Biomarkers in Diabetic Glomerulopathy Using Integrated Bioinformatics Analysis., PMID:38292407
Berberine alleviates inflammation and suppresses PLA2-COX-2-PGE2-EP2 pathway through targeting gut microbiota in DSS-induced ulcerative colitis., PMID:38154262
Meta-analysis reveals differential gene expression in tetralogy of Fallot versus controls., PMID:38146097
Applying a novel kinomics approach to study decidualization and the effects of antigestagens using a canine model†., PMID:38079525
PPARγ regulates lipid metabolism and viability of sheep trophoblast cells., PMID:37712626
Demonstration of the impact of COVID-19 on metabolic associated fatty liver disease by bioinformatics and system biology approach., PMID:37657050
Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis., PMID:37633117
Suppression of PGE2/EP2 signaling alleviates Hirschsprung disease by upregulating p38 mitogen-activated protein kinase activity., PMID:37522903
Cold stimulation causes oxidative stress, inflammatory response and apoptosis in broiler heart via regulating Nrf2/HO-1 and NF-κB pathway., PMID:37463527
Cadmium exposure caused cardiotoxicity in common carps (Cyprinus carpio L.): miR-9-5p, oxidative stress, energetic impairment, mitochondrial division/fusion imbalance, inflammation, and autophagy., PMID:37245677
Far upstream element-binding protein 1 confers lobaplatin resistance by transcriptionally activating PTGES and facilitating the arachidonic acid metabolic pathway in osteosarcoma., PMID:37180822
PTGES Expression Is Associated with Metabolic and Immune Reprogramming in Pancreatic Ductal Adenocarcinoma., PMID:37108468
Regulation of inflammatory genes in decidual cells: Involvement of the bromodomain and extra-terminal family proteins., PMID:36897880
Analgesic effects of a highly selective mPGES-1 inhibitor., PMID:36849491
Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective., PMID:36694204
Identifying the mechanisms and molecular targets of Hongjingtian injection on treatment of TGFβ1-induced HK-2 cells: coupling network pharmacology with experimental verification., PMID:36660701
Heavy-ion radiation-induced colitis and colorectal carcinogenesis in Il10-/- mice display co-activation of β-catenin and NF-κB signaling., PMID:36584137
Transcriptomic profiling of canine decidualization and effects of antigestagens on decidualized dog uterine stromal cells., PMID:36535952
Artificial rearing alters intestinal microbiota and induces inflammatory response in piglets., PMID:36274738
For research use only. Not for human or drug use.
