Catalog No.
YHA09301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu48-Leu320
Predicted molecular weight
33.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00327
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Basic-helix-loop-helix-PAS protein MOP3, ARNTL, Member of PAS protein 3, PAS domain-containing protein 3, BMAL1, Aryl hydrocarbon receptor nuclear translocator-like protein 1, BHLHE5, Class E basic helix-loop-helix protein 5, bHLHe5, MOP3, Brain and muscle ARNT-like 1, bHLH-PAS protein JAP3, PASD3
Loss of ARNTL Enhances ER Stress and Apoptosis in CKD Through Disruption of NRF2 Signaling., PMID:40489010
BMAL1 in Ischemic Heart Disease: A Narrative Review from Molecular Clock to Myocardial Pathology., PMID:40429770
Stat3 Silencing Affects Circadian Clock Gene Expression and Lipopolysaccharide Response in the Suprachiasmatic Nucleus, Cortex, and Glioblastoma Cell Cultures., PMID:40353946
Marine n-3 polyunsaturated fatty acids slow sleep impairment progression by regulating central circadian rhythms in type 2 diabetes., PMID:40347940
Circadian clock-gated cell renewal controls time-dependent changes in taste sensitivity., PMID:40339128
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury., PMID:40269168
ATG9B-4 accelerates the proliferation and migration of liver cancer cells in an ARNTL-CDK5 pathway-dependent manner: A case-control study., PMID:40258750
Ji-Ming-San enhances intestinal circadian rhythms and mitigates colitis in mice: The role of epithelial RORα., PMID:40252431
The transcription factor BMAL1 inhibits endothelial cell apoptosis by targeting STAT6 to repress its expression., PMID:40246133
Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS-Bmal1-/- Mice., PMID:40241474
Aminooxyacetic acid up-regulates the Cry1 and Bmal1 clock gene in a sirtuin 1 dependent manner. In vitro study., PMID:40210100
IL-17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease., PMID:40208086
Glyphosate exposure impairs glucose and lipid metabolism by disturbing the circadian clock system in mice liver., PMID:40204262
Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 ubiquitination., PMID:40202498
Generation of Myeloid-Specific Bmal1 Knockout Mice and Identification of Bmal1-Regulated Ferroptosis in Macrophages., PMID:40197722
Assessment of continuous positive airway pressure effect on the circadian clock signaling pathway in obstructive sleep apnea patients., PMID:40175421
Circadian clock disruption promotes retinal photoreceptor degeneration., PMID:40171795
Circadian rhythm disruption promotes M1 macrophages polarization exacerbating the inflammatory response in rosacea., PMID:40167798
Pharmacological targeting of BMAL1 modulates circadian and immune pathways., PMID:40133642
Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity., PMID:40127275
Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum., PMID:40118822
Cigarette smoking modulates m6A modification, affecting the induction of CYP1A1 mRNA by regulating human ARNT and AHRR in A549 cells., PMID:40118351
Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus., PMID:40117332
BMAL1 attenuates intervertebral disc degeneration by activating the SIRT1/PGC-1α pathway: evidence from vitro studies., PMID:40113885
Co-Exposure to Polystyrene Microplastics and Bisphenol A Contributes to the Formation of Liver Fibrosis in Mice through Inhibition of the BMAL1/E-Cad Signaling Pathway., PMID:40073227
Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice., PMID:40069567
Circadian rhythm defects in Prader-Willi syndrome neurons., PMID:40023766
Bmal1 knockout aggravates Porphyromonas gingivalis-induced periodontitis by activating the NF-κB pathway., PMID:40008712
Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis., PMID:40000642
Disruption of thyroid-intrinsic clock aggravates experimental autoimmune thyroiditis., PMID:39998446
Circadian clock genes and cell survival in bipolar disorder: Insights into lithium responsiveness and molecular mechanisms in patient-derived neural progenitor cells and mouse neurons., PMID:39995020
BMAL1 Regulates Collagen Production in the Myometrium and Leiomyomas., PMID:39966227
Global mapping of BMAL1 protein-DNA interactions in human retinal Müller cells., PMID:39959169
Elucidating the Interplay of Hypoxia-Inducible Factor and Circadian Clock Signaling in Obstructive Sleep Apnea Patients., PMID:39940739
Scheduled Exercise Partially Offsets Alcohol-Induced Clock Dysfunction in Skeletal Muscle and Liver of Female Mice., PMID:39924857
Modulatory effects of cinnamomi cortex and its components epicatechin and linalool on skin circadian rhythms., PMID:39915616
Identifying CSNK1E as a therapeutic target in thyroid cancer among the core circadian clock genes., PMID:39904793
BMAL1 rescued the hippocampus-dependent recognition memory induced by sleep deprivation., PMID:39904474
A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice., PMID:39900971
Sex-dependent association of central circadian clock gene polymorphisms with clinical risk markers for noncommunicable diseases in the young population., PMID:39894351
Circadian clockwork controls the balance between mitochondrial turnover and dynamics: What is life … without time marking?, PMID:39880150
Circadian rhythm disruption aggravates alveolar bone loss in rat apical periodontitis., PMID:39871453
Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review., PMID:39870641
Circadian rhythm, hypoxia, and cellular senescence: From molecular mechanisms to targeted strategies., PMID:39863143
Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD., PMID:39858471
BMAL1 improves assisted reproductive technology outcomes in patients with polycystic ovary syndrome by targeting BMP6 and regulating ovarian granulosa cell apoptosis., PMID:39853686
Dysregulation of the molecular clock by blood-borne factors in Alzheimer's disease patients., PMID:39812690
Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury., PMID:39812604
SIRT1/PGC-1α-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments., PMID:39810231
The correlation of shift work and CLOCK, BMAL1, and PER1 gene polymorphisms with hypertension in healthcare workers: A cross-sectional study., PMID:39809202
For research use only. Not for human or drug use.
