Catalog No.
YMK12301
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ile2-Asn127
Predicted molecular weight
15.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O70273
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ETS domain-containing transcription factor, ESE-3, ESE3B, Epithelium-specific Ets transcription factor 3, ESE3, EHF, ETS homologous factor, hEHF, ESEJ
EHF promotes liver cancer progression by meditating IL-6 secretion through transcription regulation of KDM2B in TAMs., PMID:39971220
TMB Signature-Related RCAN2 Promotes Apoptosis by Upregulating EHF/DR5 Pathway in Hepatocellular Carcinoma., PMID:39082336
ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B., PMID:38880187
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis., PMID:38781975
Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf., PMID:38513137
European Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention - part 3: topiramate., PMID:37814223
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 2: flunarizine., PMID:37723437
NEAT1_2/RRAD/EHF Positive Feedback Loop Facilitates Aerobic Glycolysis in Papillary Thyroid Cancer Cells., PMID:37279586
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 1: amitriptyline., PMID:37038134
European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure., PMID:36224519
ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour-stromal IL-1β/NF-κB/ESE3 signalling axis., PMID:35986089
Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression., PMID:35606410
The International Headache Congress - IHS and EHF joint congress 2021 : Virtual. 8-12 September 2021., PMID:34488620
Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-κB signaling pathway., PMID:34482266
Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1., PMID:34452885
EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis., PMID:34180969
Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer., PMID:34014591
EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non‑small cell lung cancer cells., PMID:33907840
EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression., PMID:33712555
Evidence for CAT gene being functionally involved in the susceptibility of COVID-19., PMID:33710662
ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4., PMID:33674341
Loss of EHF facilitates the development of treatment-induced neuroendocrine prostate cancer., PMID:33414441
EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling., PMID:32372436
Expression and prognostic significance of epithelial tissue-specific transcription factor ESE3 in hepatocellular carcinoma., PMID:32347431
Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region., PMID:31557407
Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma., PMID:31409603
Integrated analysis of gene expression profiles identifies transcription factors potentially involved in psoriasis pathogenesis., PMID:30825251
A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway., PMID:30782177
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma., PMID:30733283
Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites., PMID:30315111
ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer., PMID:30200227
miR‑206 inhibits cancer initiating cells by targeting EHF in gastric cancer., PMID:28714026
Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity., PMID:28549169
Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease., PMID:28461336
Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis., PMID:28262670
Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression., PMID:28215940
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin., PMID:27923832
MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression., PMID:27820701
Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer., PMID:27787520
The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment., PMID:27732936
Involvement of ESE-3, epithelial-specific ETS factor family member 3, in transactivation of the ABCB1 gene via pregnane X receptor in intestine-derived LS180 cells but not in liver-derived HepG2 cells., PMID:27567379
Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3., PMID:27517321
Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer., PMID:27197175
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis., PMID:26417704
The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells., PMID:26297757
Knockdown of EHF inhibited the proliferation, invasion and tumorigenesis of ovarian cancer cells., PMID:26258986
Abnormal Localization and Tumor Suppressor Function of Epithelial Tissue-Specific Transcription Factor ESE3 in Esophageal Squamous Cell Carcinoma., PMID:25950810
Polymorphisms of EHF-ELF5 genomic region and its association with pediatric asthma in the Taiwanese population., PMID:25648666
BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization., PMID:25115300
Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells., PMID:24219556
For research use only. Not for human or drug use.
