Catalog No.
EHK11601
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Asp431
Predicted molecular weight
46.94 kDa
Nature
Recombinant
Concentration
0.63 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>80% as determined by SDS-PAGE.
Accession
Q6HA08
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Oocyte astacin, Astacin-like metalloendopeptidase, ZP2-proteinase, ASTL, Ovastacin
BRAF V600E positive papillary thyroid carcinoma (TERT and TP53 mutation coexistence excluded): Correlation of clinicopathological features and the extent of surgical treatment and its complications., PMID:40033809
Tick-Borne Encephalitis Virus Surveillance-Vaccination- and Infection-Induced Seroprevalences in Western Austria 2024., PMID:39660431
Salivary glands - a new site of Helicobacter pylori occurrence., PMID:39434511
Anti-Spike IgG antibodies as correlates of protection against SARS-CoV-2 infection in the pre-Omicron and Omicron era., PMID:39105391
HemoCue Hb-801 Provides More Accurate Hemoglobin Assessment in Blood Donors Than OrSense NBM-200., PMID:38581862
RET fusion genes in pediatric and adult thyroid carcinomas: cohort characteristics and prognosis., PMID:37882481
Ovastacin: An oolemma protein that cleaves the zona pellucida to prevent polyspermy., PMID:37643828
Novel biallelic ASTL variants are associated with polyspermy and female infertility: A successful live birth following ICSI treatment., PMID:37640117
In silico identification and characterization of the SNPs in the human ASTL gene and their probable role in female infertility., PMID:37363721
Bi-allelic variants in ASTL cause abnormal fertilization or oocyte maturation defects., PMID:37133443
Multi-Omic Profiling, Structural Characterization, and Potent Inhibitor Screening of Evasion-Related Proteins of a Parasitic Nematode, Haemonchus contortus, Surviving Vaccine Treatment., PMID:36830947
Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria: Updated Analysis Involving 22,607 Blood Donors Covering the Period October 2021 to April 2022., PMID:36146684
Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice., PMID:36115280
Seroprevalence, Waning and Correlates of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria: Large-Scale Study of 35,193 Blood Donors Conducted between June 2020 and September 2021., PMID:35336975
Disorder Genes Regulate the Progression of Ischemic Stroke through the NF-κB Signaling Pathway., PMID:34746300
ASTL is mutated in female infertility., PMID:34704130
Prevalence of SARS-CoV-2 antibodies in healthy blood donors from the state of Tyrol, Austria, in summer 2020., PMID:34698961
Astragaloside IV ameliorates fat metabolism in the liver of ageing mice through targeting mitochondrial activity., PMID:34402182
The detection of SAS1B in serum provides clues for early diagnosis of thyroid cancer., PMID:33629311
Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach., PMID:33369214
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment., PMID:32946206
Dissecting Molecular Principles of the Hsp90 Chaperone Regulation by Allosteric Modulators Using a Hierarchical Simulation Approach and Network Modeling of Allosteric Interactions: Conformational Selection Dictates the Diversity of Protein Responses and Ligand-Specific Functional Mechanisms., PMID:32941034
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes., PMID:32755581
Allosteric Mechanism of the Hsp90 Chaperone Interactions with Cochaperones and Client Proteins by Modulating Communication Spines of Coupled Regulatory Switches: Integrative Atomistic Modeling of Hsp90 Signaling in Dynamic Interaction Networks., PMID:32519853
RET, NTRK, ALK, BRAF, and MET Fusions in a Large Cohort of Pediatric Papillary Thyroid Carcinomas., PMID:32495721
Exploring Mechanisms of Communication Switching in the Hsp90-Cdc37 Regulatory Complexes with Client Kinases through Allosteric Coupling of Phosphorylation Sites: Perturbation-Based Modeling and Hierarchical Community Analysis of Residue Interaction Networks., PMID:32492340
Dynamic View of Allosteric Regulation in the Hsp70 Chaperones by J-Domain Cochaperone and Post-Translational Modifications: Computational Analysis of Hsp70 Mechanisms by Exploring Conformational Landscapes and Residue Interaction Networks., PMID:31935082
Establishing Computational Approaches Towards Identifying Malarial Allosteric Modulators: A Case Study of Plasmodium falciparum Hsp70s., PMID:31717270
Interrogating Regulatory Mechanisms in Signaling Proteins by Allosteric Inhibitors and Activators: A Dynamic View Through the Lens of Residue Interaction Networks., PMID:31707705
The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases., PMID:31604990
Data-driven computational analysis of allosteric proteins by exploring protein dynamics, residue coevolution and residue interaction networks., PMID:31330173
A systematic review on the genetic analysis of paragangliomas: primarily focused on head and neck paragangliomas., PMID:31307198
Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis., PMID:31118423
Atomistic Modeling of the ABL Kinase Regulation by Allosteric Modulators Using Structural Perturbation Analysis and Community-Based Network Reconstruction of Allosteric Communications., PMID:31017783
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases., PMID:30679641
Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice., PMID:29358633
Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida., PMID:28911209
Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse., PMID:28178360
Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion., PMID:28137755
A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice., PMID:28114310
[Effect and mechanism of traditional Chinese herbs against Aβ expression in brain tissues of mice with Alzheimer's disease]., PMID:27821233
Recombinant fetuin-B protein maintains high fertilization rate in cumulus cell-free mouse oocytes., PMID:27733489
Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility., PMID:27733488
Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors., PMID:26327203
Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B., PMID:25205729
Thyroid carcinoma surgery in children and adolescents - 15 years experience surgery of pediatric thyroid carcinoma., PMID:24794415
Prevalence of Helicobacter pylori in adenotonsillar hypertrophy in children., PMID:24256044
SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition., PMID:24038607
Presence of different genotypes of Helicobacter pylori in patients with chronic tonsillitis and sleep apnoea syndrome., PMID:23864246
Detection of Helicobacter pylori in oropharyngeal lymphatic tissue with real-time PCR and assessment of its carcinogenic potential., PMID:23744180
For research use only. Not for human or drug use.
