Catalog No.
YHK07501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly326-Ser699
Predicted molecular weight
40.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H013
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MADDAM, MLTNB, Metalloprotease and disintegrin dendritic antigen marker, Meltrin-beta, ADAM19, Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19
Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)., PMID:40117561
IER3: exploring its dual function as an oncogene and tumor suppressor., PMID:40090972
Rejuvenating Hyaline Cartilage with Senescence-Targeting Si-ADAM19 Delivery for Osteoarthritis Therapy., PMID:39927476
Potential drug targets for asthma identified through mendelian randomization analysis., PMID:39806440
ADAM Metallopeptidase domain 19 promotes skin fibrosis in systemic sclerosis via neuregulin-1., PMID:39716051
Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells., PMID:39461016
Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model., PMID:39153120
Exosomal circ_0000735 contributes to non-small lung cancer malignant progression., PMID:38528705
YY1-induced lncRNA00511 promotes melanoma progression via the miR-150-5p/ADAM19 axis., PMID:38455406
ADAM19 cleaves the PTH receptor and associates with brachydactyly type E., PMID:38331475
Long non-coding RNA LINC00565 regulates ADAM19 expression through sponging microRNA-532-3p, thereby facilitating clear cell renal cell carcinoma progression., PMID:38149560
High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome., PMID:38114349
Potential drug targets for asthma identified in the plasma and brain through Mendelian randomization analysis., PMID:37809092
miR-146b-5p downregulates IRAK1 and ADAM19 to suppress trophoblast proliferation, invasion, and migration in miscarriage†., PMID:37676254
Intrauterine Smoke Exposure, microRNA Expression during Human Lung Development, and Childhood Asthma., PMID:37175432
Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7., PMID:36890812
Synovial mesenchymal stem cell-derived exosomal microRNA-320c facilitates cartilage damage repair by targeting ADAM19-dependent Wnt signalling in osteoarthritis rats., PMID:36862227
MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility., PMID:36497065
Human umbilical cord mesenchymal stem cell-derived exosomal miR-335-5p attenuates the inflammation and tubular epithelial-myofibroblast transdifferentiation of renal tubular epithelial cells by reducing ADAM19 protein levels., PMID:35902972
An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model., PMID:35757773
Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia., PMID:35694536
Global Gene Expression and Docking Profiling of COVID-19 Infection., PMID:35480316
ADAM19 and TUBB1 Correlate with Tumor Infiltrating Immune Cells and Predicts Prognosis in Osteosarcoma., PMID:35388751
Pan-tumor screening for NTRK gene fusions using pan-TRK immunohistochemistry and RNA NGS fusion panel testing., PMID:35007853
Synovial mesenchymal stem cell-derived exosomal miR-320c enhances chondrogenesis by targeting ADAM19., PMID:34927445
Platelet-Released Growth Factors Induce Genes Involved in Extracellular Matrix Formation in Human Fibroblasts., PMID:34638874
A Disintegrin and Metalloproteinase (ADAM) Family: Their Significance in Malignant Tumors of the Central Nervous System (CNS)., PMID:34638718
MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury., PMID:33775119
The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer., PMID:33548228
Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of β-Catenin, BRG1, and KDM4., PMID:33043016
Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance., PMID:32960074
Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis., PMID:32844346
Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer., PMID:32693820
Effect of indole-3-carbinol on transcriptional profiling of wound-healing genes in macrophages of systemic lupus erythematosus patients: an RNA sequencing assay., PMID:32517571
Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration., PMID:32277175
Long noncoding RNA NORAD regulates lung cancer cell proliferation, apoptosis, migration, and invasion by the miR-30a-5p/ADAM19 axis., PMID:32055266
Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells., PMID:32042028
Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array., PMID:31675985
Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate., PMID:31618630
MiR-874-3p suppresses cell proliferation and invasion by targeting ADAM19 in nasopharyngeal carcinoma., PMID:31352763
MiR-145 changes sensitivity of non-small cell lung cancer to gefitinib through targeting ADAM19., PMID:31298334
Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system., PMID:31236626
EMT is associated with an epigenetic signature of ECM remodeling genes., PMID:30814494
Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq., PMID:30802296
Aberrant expression of enzymes regulating m6A mRNA methylation: implication in cancer., PMID:30766746
A candidate gene identification strategy utilizing mouse to human big-data mining: "3R-tenet" in COPD genetic research., PMID:29871630
Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach., PMID:29692868
EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma., PMID:29582409
Xenopus ADAM19 regulates Wnt signaling and neural crest specification by stabilizing ADAM13., PMID:29540504
Cut loose and run: The complex role of ADAM proteases during neural crest cell development., PMID:29476604
For research use only. Not for human or drug use.
