Catalog No.
YHK06101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile30-Gln128
Predicted molecular weight
38.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HC23
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PK2, Prokineticin-2, PROK2, BV8, Protein Bv8 homolog
Identification of Novel Genetic Variants in a Cohort of Congenital Hypogonadotropic Hypogonadism: Computational Analysis of Pathogenicity Predictions., PMID:40508017
Analysis of the inflammatory gene expression characteristics and immune microenvironment regulatory mechanisms in the testicular tissue of patients with non-obstructive azoospermia., PMID:40460050
Neurokinin 3 receptor agonist senktide stimulates GnRH release in isolated hypogonadotropic hypogonadism mice., PMID:40135619
Prok2/PKR signaling regulates ferroptosis after spinal cord injury., PMID:39978670
Uncovering the role of prokineticin pathway on Epicardial Adipose Tissue (EAT) development and EAT-associated cardiomyopathy., PMID:39955015
Possible therapeutic effects of PROK2 in testicular ischemia/reperfusion injury: A preclinical study in Wistar albino rats., PMID:39946968
The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium., PMID:39915377
Gallic acid mitigates lipopolysaccharide-induced testicular inflammation via regulation of the NF-κB and PK2/PKR1 pathway., PMID:39825958
Prokineticin 2 protein is diurnally expressed in PER2-containing clock neurons in the mouse suprachiasmatic nucleus., PMID:39755259
Machine Learning Integration with Single-Cell Transcriptome Sequencing Datasets Reveals the Impact of Tumor-Associated Neutrophils on the Immune Microenvironment and Immunotherapy Outcomes in Gastric Cancer., PMID:39684426
SPHK2 Knockdown Inhibits the Proliferation and Migration of Fibroblast-Like Synoviocytes Through the IL-17 Signaling Pathway in Osteoarthritis., PMID:39416266
Clinical value of prokineticin 2 in the diagnosis of neonatal necrotizing enterocolitis., PMID:39141663
Prokineticin-2 Is Highly Expressed in Colonic Mucosa of Early Parkinson's Disease Patients., PMID:39051733
Diverse genetic alteration dysregulates neuropeptide and intracellular signalling in the suprachiasmatic nuclei., PMID:38924215
Intracerebroventricular PROK2 infusion could increase the secretion of male reproductive hormones by stimulating the HPG axis., PMID:38740671
Lycopene inhibits apoptosis of mouse spermatocytes in varicocele via miR-23a/b-induced downregulation of PROK2., PMID:38301353
Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse., PMID:38057865
Investigation of the molecular genetic causes of non-syndromic primary ovarian ınsufficiency by next generation sequencing analysis., PMID:37988663
Prokineticin-2 Participates in Chronic Constriction Injury-Triggered Neuropathic Pain and Anxiety via Regulated by NF-κB in Nucleus Accumbens Shell in Rats., PMID:37934398
Effects of Prokineticins on Cerebral Cell Function and Blood-Brain Barrier Permeability., PMID:37895111
ANALYSIS AND IDENTIFICATION OF FERROPTOSIS-RELATED GENE SIGNATURE FOR ACUTE LUNG INJURY., PMID:37878471
In vivo recording of the circadian calcium rhythm in Prokineticin 2 neurons of the suprachiasmatic nucleus., PMID:37813987
Inferring circadian gene regulatory relationships from gene expression data with a hybrid framework., PMID:37752445
Potential Confounders in Study Stating That Levels of Prokineticin-2 Were Significantly Higher in Septic Shock Than Sepsis., PMID:37707386
Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula., PMID:37463657
PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency., PMID:37338295
Genetic Analysis of Patients with Congenital Hypogonadotropic Hypogonadism: A Case Series., PMID:37108593
Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer., PMID:37090721
Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders., PMID:36843573
Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes., PMID:36804440
Integrated multiple microarray studies by robust rank aggregation to identify immune-associated biomarkers in Crohn's disease based on three machine learning methods., PMID:36792688
Clinical Characteristics and Genetic Analyses of Patients with Idiopathic Hypogonadotropic Hypogonadism., PMID:36700485
A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism., PMID:36694982
Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction., PMID:36549578
Inhibition of miR-141-3p attenuates apoptosis of neural stem cells via targeting PBX1 to regulate PROK2 transcription in MCAO mice., PMID:36548024
Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2., PMID:36539034
Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner., PMID:36513690
Identification of perturbed pathways rendering susceptibility to tuberculosis in type 2 diabetes mellitus patients using BioNSi simulation of integrated networks of implicated human genes., PMID:36476775
Prokineticin 2/PROK2 and Male Infertility., PMID:36289651
PROK2, HRNR, and FIG4 as potential genetic biomarkers of high bleeding propensity in East Asian patients with acute coronary syndrome using ticagrelor., PMID:36263704
Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease., PMID:36218142
Alzheimer's disease-associated inflammatory pathways might contribute to osteoporosis through the interaction between PROK2 and CSF3., PMID:36203970
PROK2-PROKR2 Signaling: New Contributor to Pleasant Touch., PMID:35960443
Prokineticin 2 in cancer-related inflammation., PMID:35921971
Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity., PMID:35908898
Prokineticins as a Prognostic Biomarker for Low-Grade Gliomas: A Study Based on The Cancer Genome Atlas Data., PMID:35845958
Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review., PMID:35236788
Regional genotypic variations in normosmic congenital hypogonadotropic hypogonadism: our experience and systematic review., PMID:35133534
Interplay between Prokineticins and Histone Demethylase KDM6A in a Murine Model of Bortezomib-Induced Neuropathy., PMID:34769347
For research use only. Not for human or drug use.
