Catalog No.
YHK06001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg240-Ala309
Predicted molecular weight
34.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HC97
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KYNA receptor, Kynurenic acid receptor, GPR35, G-protein coupled receptor 35
GPR35 prevents drug-induced liver injury via the Gαs-cAMP-PKA axis in macrophages., PMID:40437264
The gut-brain axis mechanism of normal appetite induced by kynurenic acid., PMID:40317720
G protein-coupled receptor 35 suppresses oxidative stress response 1 in diabetic wound healing., PMID:40267342
Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts., PMID:40215127
GPR35 prevents osmotic stress induced cell damage., PMID:40121360
Activation of GPR35 by kynurenic acid inhibits IL-1β secretion in macrophages during CR-hvKP-induced pneumonia., PMID:40106903
Hippocampal GPR35 is involved in the depression-like behaviors induced by inflammation and mediates the antidepressant effects of fluoxetine in mice., PMID:39978696
Genetic Susceptibility and Disease Activity in Ankylosing Spondylitis: The Role of G Protein-Coupled Receptor 35rs4676410 Polymorphism in a Turkish Population., PMID:39918909
Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD., PMID:39873004
Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice., PMID:39744893
Biased constitutive signaling of the G protein-coupled receptor GPR35 suppresses gut barrier permeability., PMID:39615676
GPR35 agonists inhibit TRPA1-mediated colonic nociception through suppression of substance P release., PMID:39382322
The role of kynurenines in migraine-related neuroimmune pathways., PMID:39107712
Role of orphan G-protein coupled receptors in tissue ischemia: A comprehensive review., PMID:38906238
Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ1-42 in Mice., PMID:38878116
The tryptophan metabolic pathway of the microbiome and host cells in health and disease., PMID:38869080
Revolutionizing GPCR-ligand predictions: DeepGPCR with experimental validation for high-precision drug discovery., PMID:38864340
Ethanol Extract of Limonium bicolor Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Alleviating Inflammation and Restoring Gut Microbiota Dysbiosis in Mice., PMID:38667792
From orphan to oncogene: The role of GPR35 in cancer and immune modulation., PMID:38514303
Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia., PMID:38513777
Mast cells help organize the Peyer's patch niche for induction of IgA responses., PMID:38427721
Endothelial YAP/TEAD1-CXCL17 signaling recruits myeloid-derived suppressor cells against liver ischemia-reperfusion injury., PMID:38407233
Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate., PMID:38290974
A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior., PMID:38198925
Preliminary study on whole genome methylation and transcriptomics in age-related cataracts., PMID:38128790
Tryptophan metabolism as a 'reflex' feature of neuroimmune communication: Sensor and effector functions for the indoleamine-2, 3-dioxygenase kynurenine pathway., PMID:38102897
GPR35 acts a dual role and therapeutic target in inflammation., PMID:38035084
Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD., PMID:37976806
Gallic acid induces osteoblast differentiation and alleviates inflammatory response through GPR35/GSK3β/β-catenin signaling pathway in human periodontal ligament cells., PMID:37957813
Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord., PMID:37735678
Eriodictyol and thymonin act as GPR35 agonists., PMID:37667527
G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions., PMID:37660910
Pamoic acid-induced peripheral GPR35 activation improves pruritus and dermatitis., PMID:37501600
Activation of the GPR35 on ILC2 drives immunosuppression to promote lung cancer progression., PMID:37424810
GPR35-mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis., PMID:37423235
Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging., PMID:37300401
Kynurenic acid promotes osteogenesis via the Wnt/β-catenin signaling., PMID:37291335
Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system., PMID:37279752
Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand., PMID:37227682
What defines a chemokine? - The curious case of CXCL17., PMID:37210967
GPR35 antagonist CID-2745687 attenuates anchorage-independent cell growth by inhibiting YAP/TAZ activity in colorectal cancer cells., PMID:37113762
Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35., PMID:37077394
Aminosalicylates target GPR35, partly contributing to the prevention of DSS-induced colitis., PMID:37054942
Neuroglobin plays as tumor suppressor by disrupting the stability of GPR35 in colorectal cancer., PMID:37005662
GPR35: from enigma to therapeutic target., PMID:37002007
G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes., PMID:36970193
GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation., PMID:36928841
Gpr35 shapes gut microbial ecology to modulate hepatic steatosis., PMID:36758734
Identification and development of a five-gene signature to improve the prediction of mechanical ventilator-free days for patients with COVID-19., PMID:36734721
5-Hydroxyindoleacetic acid, a new ligand for GPR35, plays an important role in inflammatory disease., PMID:36647721
For research use only. Not for human or drug use.
