Catalog No.
YHK05401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys193
Predicted molecular weight
23.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92843
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Bcl-2-like protein 2, BCL2L2, Bcl2-L-2, KIAA0271, Apoptosis regulator Bcl-W, BCLW
Taurine alleviated acrylamide-induced ovarian toxicity via suppression of oxidative stress and apoptosis in mice., PMID:40250412
Integrating bulk RNA-seq and scRNA-seq data to explore diverse cell death patterns and develop a programmed cell death-related relapse prediction model in pediatric B-ALL., PMID:39955305
Onvansertib and Navitoclax Combination as a New Therapeutic Option for Mucinous Ovarian Carcinoma., PMID:39859203
Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells., PMID:39394673
Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor., PMID:39067448
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology., PMID:38230771
Marine Natural Compound (Neviotin A) Displays Anticancer Efficacy by Triggering Transcriptomic Alterations and Cell Death in MCF-7 Cells., PMID:37687120
BCL-W makes only minor contributions to MYC-driven lymphoma development., PMID:37567974
m6A-mediated upregulation of miRNA-193a aggravates cardiomyocyte apoptosis and inflammatory response in sepsis-induced cardiomyopathy via the METTL3/ miRNA-193a/BCL2L2 pathway., PMID:37414203
Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome., PMID:36969496
Estrogen-dependent activation of NCOA3 couples with p300 and NF-κB to mediate antiapoptotic genes in ER-positive breast cancer cells., PMID:36853387
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma., PMID:36829221
Breast cancer sub-types display heterogeneity in gene amplification and mRNA expression of the anti-apoptotic members of BCL2 family., PMID:36627096
MiR-140 promotes the progression of intracranial aneurysms by targeting BCL2L2., PMID:36441929
Sequence and expression regulation of the BCL2L2 gene in pigs., PMID:36272652
A BDNF-TrkB autocrine loop enhances senescent cell viability., PMID:36266274
Molecular alterations in anti-apoptotic BCL2 family proteins in breast cancer cell line models, drug sensitivities and dependencies to guide the development of BCL2 inhibitors., PMID:36100115
In silico mutational analysis to identify the role and pathogenicity of BCL-w missense variants., PMID:35951173
Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells., PMID:35894779
Evaluation of the interaction between anti-apoptotic Bcl-2 protein family mRNA expression and autophagy gene Bcl-1 expression in Egyptian SLE patients., PMID:35657769
LINC00152 knockdown suppresses tumorigenesis in non-small cell lung cancer via sponging miR-16-5p., PMID:35399229
Characterization of a Read-through Fusion Transcript, BCL2L2-PABPN1, Involved in Porcine Adipogenesis., PMID:35327999
Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells., PMID:34620126
BCL-W expression associates with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified., PMID:34531377
Expression of BCL2L12and LIPOCALIN 2 in Adult Patient with Acute Myeloid Leukemia and Correlation with Clinical Response., PMID:34319051
Long non-coding RNA XIST regulates ovarian cancer progression via modulating miR-335/BCL2L2 axis., PMID:34090463
MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis., PMID:33974236
PCR array analysis identified hyperproliferation but not autophagy or apoptosis in fibrous epulis., PMID:33934404
BCL2L2 loss renders -14q renal cancer dependent on BCL2L1 that mediates resistance to tyrosine kinase inhibitors., PMID:33784008
Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis., PMID:33744257
Prolactin Rescues Immature B Cells from Apoptosis-Induced BCR-Aggregation through STAT3, Bcl2a1a, Bcl2l2, and Birc5 in Lupus-Prone MRL/lpr Mice., PMID:33557010
BCL2 Interacting Protein 3-like/NIX-mediated Mitophagy Plays an Important Role in the Process of Age-related Hearing Loss., PMID:33346118
miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells., PMID:33128129
WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target., PMID:32580769
Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line., PMID:32400328
BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy., PMID:32335811
BCL-w: apoptotic and non-apoptotic role in health and disease., PMID:32317622
Synergistic Apoptotic Effects of Bortezomib and Methylstat on Multiple Myeloma Cells., PMID:32111493
MiR-93 Inhibits Trophoblast Cell Proliferation and Promotes Cell Apoptosis by Targeting BCL2L2 in Recurrent Spontaneous Abortion., PMID:32046397
Long noncoding RNA colorectal neoplasia differentially expressed alleviates sepsis-induced liver injury via regulating miR-126-5p., PMID:32031750
BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines., PMID:31985804
Rs1894720 polymorphism is associated with the risk of age-related cataract by regulating the proliferation of epithelial cells in the lens via the signalling pathway of MIAT/miR-26b/BCL2L2., PMID:35154542
Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma., PMID:31927215
LncRNA RMST-mediated miR-107 transcription promotes OGD-induced neuronal apoptosis via interacting with hnRNPK., PMID:31852624
Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation., PMID:31727122
Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities., PMID:31640099
Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma., PMID:31636344
Deletion of miR-15 Protects Against Rheumatoid Arthritis via Deregulating its Target Gene BCL2L2 and Repressing NF-κB Pathway., PMID:31611200
Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer., PMID:31462500
miRNA-125a-5p inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting TP53 regulated inhibitor of apoptosis 1 and Bcl-2-like-2 protein., PMID:31316614
For research use only. Not for human or drug use.
