Catalog No.
YHK05001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe593-Phe1077
Predicted molecular weight
57.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZJ5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EIF2AK3, HsPEK, PERK, PEK, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, Eukaryotic translation initiation factor 2-alpha kinase 3
Resting Ca2+ fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming., PMID:40515767
Endoplasmic reticulum stress sensor protein PERK in hepatic stellate cells promotes the progression of hepatocellular carcinoma via p38δ MAPK/IL-1β axis., PMID:40481076
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity., PMID:40437698
Enterohemorrhagic Escherichia coli O157:H7 Infection Inhibits Host Endoplasmic Reticulum Stress in Intestinal Epithelial Cells via the PERK Pathway., PMID:40430759
PERK Regulates Epithelial-Mesenchymal Transition Through Autophagy and Lipid Metabolism in Lens Epithelial Cells., PMID:40408092
A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC., PMID:40379966
PERK/Sestrin2 Signaling Pathway Mediated Autophagy Regulates Human Cardiomyocytes Apoptosis Induced by Traffic-Related PM2.5 and Diverse Constituents., PMID:40332408
USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells., PMID:40325079
PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape., PMID:40267909
Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer., PMID:40252311
MiR-204-5p mediates PERK inhibition to suppress growth and induce apoptosis in ovarian cancer through the eIF2α/ATF-4/CHOP pathway., PMID:40216841
The PERK/ATF4 pathway is required for metabolic reprogramming and progressive lung fibrosis., PMID:40208691
Chlamydia pneumoniae relies on host glutathione for its growth and induces integrated stress response-mediated changes in macrophage glutathione metabolism., PMID:40187637
ADSL-produced fumarate increases BECN1 dimethylation to promote autophagy and liver tumor growth., PMID:40103200
Diff erent expression of genes involved in unfolded protein response in multiple myeloma and extramedullary dis ease patients., PMID:40088436
PERK-Olating Through Cancer: A Brew of Cellular Decisions., PMID:40001551
The sV184A Variant in HBsAg Specific to HBV Subgenotype C2 Leads to Enhanced Viral Replication and Apoptotic Cell Death Induced by PERK-eIF2α-CHOP-Mediated ER Stress., PMID:39977392
Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes., PMID:39920115
Inhibition of vascular smooth muscle cell PERK/ATF4 ER stress signaling protects against abdominal aortic aneurysms., PMID:39846252
Endoplasmic reticulum stress in the salivary glands of patients with primary Sjögren's syndrome, associated Sjögren's syndrome, and non-Sjögren's sicca syndrome: a comparative analysis and the influence of chloroquine., PMID:39780265
Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation., PMID:39747098
Microtubule acetylation and PERK activation facilitate eribulin-induced mitochondrial calcium accumulation and cell death., PMID:39741209
Hepcidin inhibits hepatocyte apoptosis through the PERK pathway in acute liver injury and fibrosis., PMID:39699302
Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity., PMID:39667306
The cGAS-STING/PERK-eIF2α: Individual or Potentially Collaborative Signaling Transduction in Cardiovascular Diseases., PMID:39664570
NOX4 deficiency improves the impaired viability, inhibited the apoptosis and suppressed autophagy of DHEA-treated ovarian granulosa cells through inhibiting endoplasmic reticulum stress via inactivating PERK/ATF4 pathway., PMID:39615228
The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis., PMID:39566842
Ginsenoside Rg1 improves cigarette smoke-induced ferroptosis in COPD by regulating PERK/ATF4 axis to inhibit endoplasmic reticulum stress., PMID:39531905
(-)-Epicatechin regulates endoplasmic reticulum stress and promotes ferroptosis in lung cancer cells via the PERK/eIF2α/ATF4 signaling pathway., PMID:39480832
Identification of new therapeutic targets related to endoplasmic reticulum stress and mitochondrial dysfunction to reduce the risk of rupture in degenerative ascending aortic aneurysm., PMID:39424523
ER stress aggravates NOD1-mediated inflammatory response leading to impaired nutrient metabolism in hepatoma cells., PMID:39423570
RHBDF1 promotes PERK expression through the JNK/FoxO3 pathway in breast cancer cells., PMID:39420837
Reticulophagy and viral infection., PMID:39394962
Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stress., PMID:39394239
Genome-wide association study reveals the underlying regulatory mechanisms of red blood traits in Anadara granosa., PMID:39367301
Isovalerylspiramycin I suppresses small cell lung cancer proliferation via ATR/CHK1 mediated DNA damage response and PERK/eIF2α/ATF4/CHOP mediated ER stress., PMID:39353535
Loxenatide Alleviates High Glucose-Induced Pancreatic β-Cell Senescence via Regulating the PERK/eIF2α Pathway., PMID:39333044
Identification of autophagy-related genes as potential biomarkers correlated with immune infiltration in bipolar disorder: a bioinformatics analysis., PMID:39272120
Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis., PMID:39223663
TUDCA inhibits EV71 replication by regulating ER stress signaling pathway and suppressing autophagy., PMID:39213902
MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants., PMID:39201476
17-AAG Induces Endoplasmic Reticulum Stress-mediated Apoptosis in Breast Cancer Cells, Possibly Through PERK/eIF2α Up-regulation., PMID:39187325
Unfolded proteins in the mitochondria activate HRI and inhibit mitochondrial protein translation., PMID:39168261
Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches., PMID:39153651
The unfolded protein response sensor PERK mediates mechanical stress-induced maturation of focal adhesion complexes in glioblastoma cells., PMID:39152526
PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress., PMID:39116259
SEC24C suppresses the propagation and chemoresistance of hepatocellular carcinoma by promoting unfolded protein response-related apoptosis., PMID:39085101
IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells., PMID:39062922
Tetrahydrocurcumin Attenuates Polymyxin B Sulfate-Induced HK-2 Cells Apoptosis by Inhibiting Endoplasmic Reticulum Stress-Mediated PERK/eIF2α/ATF4/CHOP Signaling Pathway Axis., PMID:39023307
For research use only. Not for human or drug use.
