Catalog No.
YHK04901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg471-Asn727
Predicted molecular weight
32.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92556
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Engulfment and cell motility protein 1, ELMO1, Protein ced-12 homolog, KIAA0281
Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human)., PMID:40462586
LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis., PMID:40281518
The rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms are associated with changes in laboratory markers of renal damage among patients with type 2 diabetes mellitus., PMID:40271977
The C allele of the rs741301 polymorphism in the ELMO1 gene is associated with increased risk of diabetic retinopathy in patients with type 2 diabetes mellitus., PMID:40215453
C1QL1 regulates auditory nerve fibers growth via ELMO1-DOCK180-RAC1 integrin., PMID:40193629
Genomic and cellular context-dependent expression of the human ELMO1 gene transcript variants., PMID:40147730
Diabetic kidney disease and polymorphisms of the ELMO1 and AGTR1 genes: Systematic review., PMID:40038011
Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population., PMID:39967558
DOCK1/ELMO1/Rac1 Signaling is Essential for Vitreous-Induced Migration and Contraction of ARPE19 Cells., PMID:39911025
Assessing the Mechanism of Rac1b: An All-Atom Simulation Study of the Alternative Spliced Variant of Rac1 Small Rho GTPase., PMID:39632743
RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state., PMID:38857861
ELMO1 regulates macrophage directed migration and attenuates inflammation via NF-κB signaling pathway in primary biliary cholangitis., PMID:38825413
ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis., PMID:38756351
Acetylation of ELMO1 correlates with Rac1 activity and colorectal cancer progress., PMID:38750717
Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection., PMID:38746404
Variant ELMO1 rs1345365 is associated with pseudoperniosis in patients with COVID-19., PMID:38537232
Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis., PMID:38277369
RhoG-Binding Domain of Elmo1 Ameliorates Excessive Process Elongation Induced by Autism Spectrum Disorder-Associated Sema5A., PMID:38133141
Overexpression of Dock180 and Elmo1 in Melanoma is Associated with Cell Survival and Migration., PMID:38086358
Golgi ELMO1 binds QUA1, QUA2, GAUT9, and ELMO4 and is required for pectin accumulation in Arabidopsis., PMID:37939087
Diverse gut pathogens exploit the host engulfment pathway via a conserved mechanism., PMID:37890785
The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome Incidence., PMID:37594641
RNA sequencing reveals the transcriptomic landscape and alternative splicing events induced by LGALS1 silencing in non-small cell lung cancer., PMID:37341175
Nucleophosmin 1 associating with engulfment and cell motility protein 1 regulates hepatocellular carcinoma cell chemotaxis and metastasis., PMID:37251542
Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation., PMID:37188749
Recent Progress in Genetics and Epigenetics Research on Diabetic Nephropathy in Malaysia., PMID:37187702
ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis., PMID:37175809
Evidence in support of the bone marrow as the primary lesion in axial spondyloarthritis., PMID:37115850
Diverse Gut Pathogens Exploit the Host Engulfment Pathway via a Conserved Mechanism., PMID:37066267
Targeting Ras-binding domain of ELMO1 by computational nanobody design., PMID:36932164
Helicobacter pylori Eradication Can Reverse Rho GTPase Expression in Gastric Carcinogenesis., PMID:36718103
circRNA432 enhances the coelomocyte phagocytosis via regulating the miR-2008-ELMO1 axis in Vibrio splendidus-challenged Apostichopus japonicus., PMID:36709365
The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses., PMID:36694274
Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation., PMID:36563662
Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration., PMID:36400788
High-throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory-deprived cortical cholinergic VIP/CHAT neurons., PMID:36377476
Engulfment and cell motility protein 1 fosters reprogramming of tumor-associated macrophages in colorectal cancer., PMID:36310143
Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort., PMID:36308435
Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer., PMID:36288887
TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation., PMID:36179995
Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1 -/- , elmo2 -/- , and elmo3 -/- Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins., PMID:35874819
Role of ELMO1 in inflammation and cancer-clinical implications., PMID:35668246
Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes., PMID:35484513
Functional Verification of Novel ELMO1 Variants by Live Imaging in Zebrafish., PMID:34993193
TNF-α/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells., PMID:34919331
The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses., PMID:34719317
Genetic associated complications of type 2 diabetes mellitus., PMID:34609116
TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis., PMID:34508078
ELMO1 signaling is a promoter of osteoclast function and bone loss., PMID:34404802
ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts., PMID:34381782
For research use only. Not for human or drug use.
