Catalog No.
YHK04701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly6-Pro206
Predicted molecular weight
25.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HAY6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BCMO1, Beta,beta-carotene 15,15'-dioxygenase, BCDO, BCO1, Beta-carotene oxygenase 1, BCDO1, Beta-carotene dioxygenase 1
Sequence characteristics, evolutionary history and expression pattern of BCO2 in Chinese mitten crab Eriocheir sinensis., PMID:40393191
Disentangling the molecular mechanisms underlying yellow body coloration in a soft-shelled turtle., PMID:40091532
Male-Specific Effects of β-Carotene Supplementation on Lipid Metabolism in the Liver and Gonadal Adipose Tissue of Healthy Mice., PMID:40005219
Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina., PMID:39978586
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine., PMID:39971162
Genetic variants in the PKD1L2/BCO1 region are associated with β-carotene, lutein, and zeaxanthin: A genome-wide association study of plasma carotenoids., PMID:39603182
LncRNA (BCO1-AS) regulate inflammatory responses in bacterial infection through caspase-1 in turbot (Scophthalmus maximus)., PMID:39208888
NinaB and BCO Collaboratively Participate in the β-Carotene Catabolism in Crustaceans: A Case Study on Chinese Mitten Crab Eriocheir sinensis., PMID:38891781
Association of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma and Skin Carotenoid Concentrations in Adults Provided a Lycopene-Rich Juice., PMID:38797482
Bioavailability and provitamin A activity of neurosporaxanthin in mice., PMID:37864015
Lycopene Accumulation in Transgenic Mice Lacking One or Both Carotenoid Cleaving Enzymes., PMID:37269907
β-Carotene induces UCP1-independent thermogenesis via ATP-consuming futile cycles in 3T3-L1 white adipocytes., PMID:36948352
β-Cryptoxanthin Attenuates Cigarette-Smoke-Induced Lung Lesions in the Absence of Carotenoid Cleavage Enzymes (BCO1/BCO2) in Mice., PMID:36771049
The BCO2 Genotype and the Expression of BCO1, BCO2, LRAT, and TTPA Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract., PMID:36768627
A Computer Simulation Insight into the Formation of Apocarotenoids: Study of the Carotenoid Oxygenases BCO1 and BCO2 and Their Interaction with Putative Substrates., PMID:36431912
The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice., PMID:36400405
Association of MARC1, ADCY5, and BCO1 Variants with the Lipid Profile, Suggests an Additive Effect for Hypertriglyceridemia in Mexican Adult Men., PMID:36233117
Gastrointestinal genetic reprogramming of vitamin A metabolic pathways in response of Roux-en-Y gastric bypass., PMID:36164727
The Effect of the BCO2 Genotype on the Expression of Genes Related to Carotenoid, Retinol, and α-Tocopherol Metabolism in Rabbits Fed a Diet with Aztec Marigold Flower Extract., PMID:36142463
Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study., PMID:35994463
Xanthophyll β-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status in β-carotene 9',10'-oxygenase knockout mice., PMID:35464265
Common variant rs6564851 near the beta-carotene oxygenase 1 gene is associated with plasma triglycerides levels in middle-aged Mexican men adults., PMID:35461060
Regulatory mechanisms of Beta-carotene and BCMO1 in adipose tissues: A gene enrichment-based bioinformatics analysis., PMID:35306905
Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye., PMID:34836244
Fenretinide inhibits vitamin A formation from β-carotene and regulates carotenoid levels in mice., PMID:34742949
β-Carotene Bioavailability and Conversion Efficiency Are Significantly Affected by Sex in Rats: First Observation Suggesting a Possible Hormetic Regulation of Vitamin A Metabolism in Female Rats., PMID:34633772
ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people., PMID:34481002
Dietary intake of vitamin A, lung function and incident asthma in childhood., PMID:33795317
The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2., PMID:33600157
Ionone Is More than a Violet's Fragrance: A Review., PMID:33321809
β-Carotene conversion to vitamin A delays atherosclerosis progression by decreasing hepatic lipid secretion in mice., PMID:32963037
BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer., PMID:32914372
SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana., PMID:32560166
Identification of Potential Key Genes for Pathogenesis and Prognosis in Prostate Cancer by Integrated Analysis of Gene Expression Profiles and the Cancer Genome Atlas., PMID:32547947
β-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans., PMID:32433733
Molecular components affecting ocular carotenoid and retinoid homeostasis., PMID:32339666
Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases., PMID:32061750
Enzymology of vertebrate carotenoid oxygenases., PMID:32035229
Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development., PMID:32027669
Carotenoids and fatty liver disease: Current knowledge and research gaps., PMID:31904420
Xanthophyll β-Cryptoxanthin Inhibits Highly Refined Carbohydrate Diet-Promoted Hepatocellular Carcinoma Progression in Mice., PMID:31891208
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color., PMID:31882713
Interplay between β-carotene and lipoprotein metabolism at the maternal-fetal barrier., PMID:31863969
Expression and Characterization of Mammalian Carotenoid Cleavage Dioxygenases., PMID:31745914
Polymorphisms in PCSK9, LDLR, BCMO1, SLC12A3, and KCNJ1 are Associated with Serum Lipid Profile in Chinese Han Population., PMID:31480784
Dietary β-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice., PMID:31212314
β-Carotene 15,15'-oxygenase inhibits cancer cell stemness and metastasis by regulating differentiation-related miRNAs in human neuroblastoma., PMID:31048207
Carotenoid metabolic (BCO1) polymorphisms and personal behaviors modify the risk of coronary atherosclerosis: a nested case-control study in Han Chinese with dyslipidaemia (2013-2016)., PMID:30896431
Single Nucleotide Polymorphisms in β-Carotene Oxygenase 1 are Associated with Plasma Lycopene Responses to a Tomato-Soy Juice Intervention in Men with Prostate Cancer., PMID:30801647
Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes., PMID:30446518
For research use only. Not for human or drug use.
