Catalog No.
YHK04601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr324-Ala566
Predicted molecular weight
29.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NHY0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-1,4 N-acetylgalactosaminyltransferase 2, B4GALNT2, GALGT2, Sd(a) beta-1,4-GalNAc transferase, UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase
The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation., PMID:39902050
Generation and characterization of genetically modified pigs with GGTA1/β4GalNT2/CMAH knockout and human CD55/CD47 expression for xenotransfusion studies., PMID:39622959
Inhibiting T-Cell-Mediated Rejection of the Porcine Meniscus Through Freeze-Thawing and Downregulating Porcine Xenoreactive Antigen Genes., PMID:39180383
Elimination of GGTA1, CMAH, β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions., PMID:38962826
N-Glycan on the Non-Consensus N-X-C Glycosylation Site Impacts Activity, Stability, and Localization of the Sda Synthase B4GALNT2., PMID:36835549
Glycoproteomic and Phenotypic Elucidation of B4GALNT2 Expression Variants in the SID Histo-Blood Group System., PMID:35409292
B4GALNT2 Gene Promotes Proliferation, and Invasiveness and Migration Abilities of Model Triple Negative Breast Cancer (TNBC) Cells by Interacting With HLA-B Protein., PMID:34589428
Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sda synthase) gene: B4GALNT2 is transcriptionally regulated by ETS1., PMID:34500083
B4GALNT2 Controls Sda and SLex Antigen Biosynthesis in Healthy and Cancer Human Colon., PMID:34397142
Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses., PMID:34162938
Glycosyltransferase B4GALNT2 as a Predictor of Good Prognosis in Colon Cancer: Lessons from Databases., PMID:33919332
One-Step Generation of Multiple Gene-Edited Pigs by Electroporation of the CRISPR/Cas9 System into Zygotes to Reduce Xenoantigen Biosynthesis., PMID:33668187
The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease., PMID:33662872
Extensive germline genome engineering in pigs., PMID:32958897
The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition., PMID:32911675
Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons., PMID:32909301
Anti-pig IgE and IgA Antibodies in Naive Primates and Nonhuman Primates With Pig Xenografts., PMID:32796494
Reactions to Porcine Cells With or Without β4GalNT2., PMID:32482451
High Expression of the Sda Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer., PMID:32290493
An adaptive test for meta-analysis of rare variant association studies., PMID:31830326
Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2., PMID:31591751
MDCK-B4GalNT2 cells disclose a α2,3-sialic acid requirement for the 2009 pandemic H1N1 A/California/04/2009 and NA aid entry of A/WSN/33., PMID:31560252
Porcine antiviral activity is increased by CRISPRa-SAM system., PMID:31371630
Efficient base editing by RNA-guided cytidine base editors (CBEs) in pigs., PMID:31302752
Soluble Heparin Binding Epidermal Growth Factor-Like Growth Factor Is a Regulator of GALGT2 Expression and GALGT2-Dependent Muscle and Neuromuscular Phenotypes., PMID:31036568
Justification of specific genetic modifications in pigs for clinical organ xenotransplantation., PMID:30989742
The desirable donor pig to eliminate all xenoreactive antigens., PMID:30825348
The high prolificacy of D'man sheep is associated with the segregation of the FecLL mutation in the B4GALNT2 gene., PMID:30561778
The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism., PMID:30378628
Molecular Cloning of the B4GALNT2 Gene and Its Single Nucleotide Polymorphisms Association with Litter Size in Small Tail Han Sheep., PMID:30241280
The extended cytoplasmic tail of the human B4GALNT2 is critical for its Golgi targeting and post-Golgi sorting., PMID:30067891
Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH., PMID:29631050
Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?, PMID:29238731
A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor., PMID:28813663
Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice., PMID:28806915
Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone., PMID:28345428
Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs., PMID:28114170
Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation., PMID:27100221
Immunogenicity of Renal Microvascular Endothelial Cells From Genetically Modified Pigs., PMID:26906938
Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection., PMID:26133982
Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen., PMID:25176027
B4GALNT2 gene expression controls the biosynthesis of Sda and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract., PMID:24953560
The expanding roles of the Sd(a)/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2., PMID:24112972
The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary., PMID:24086150
Localization of B4GALNT2 and its role in mouse embryo attachment., PMID:22401809
Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice., PMID:22278669
Long-term balancing selection at the blood group-related gene B4galnt2 in the genus Mus (Rodentia; Muridae)., PMID:21652612
Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice., PMID:21481371
Selection on cis-regulatory variation at B4galnt2 and its influence on von Willebrand factor in house mice., PMID:19088380
DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer., PMID:18485915
For research use only. Not for human or drug use.
